SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wv4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		3 / 3 GLU A 373
HIS A 408
ASP A 360
 None
 0.83A 1i9gA-3wv4A:
undetectable		 1i9gA-3wv4A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		4 / 6 LYS A 235
VAL A 212
ILE A 238
ARG A 322
 None
 1.15A 1iepA-3wv4A:
undetectable		 1iepA-3wv4A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		5 / 12 SER A 239
ILE A 238
LEU A  25
LEU A 213
GLY A 214
 None
 1.09A 1tlsA-3wv4A:
undetectable		 1tlsA-3wv4A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		4 / 8 TYR A  97
TRP A  55
LEU A 246
MET A  48
 None
 1.33A 1uw6A-3wv4A:
undetectable
1uw6B-3wv4A:
undetectable		 1uw6A-3wv4A:
20.80
1uw6B-3wv4A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		4 / 8 TYR A  97
TRP A  55
LEU A 246
MET A  48
 None
 1.33A 1uw6D-3wv4A:
undetectable
1uw6E-3wv4A:
undetectable		 1uw6D-3wv4A:
20.80
1uw6E-3wv4A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		4 / 8 TYR A  97
TRP A  55
LEU A 246
MET A  48
 None
 1.35A 1uw6G-3wv4A:
undetectable
1uw6H-3wv4A:
undetectable		 1uw6G-3wv4A:
20.80
1uw6H-3wv4A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		4 / 8 TYR A  97
TRP A  55
LEU A 246
MET A  48
 None
 1.34A 1uw6P-3wv4A:
undetectable
1uw6Q-3wv4A:
undetectable		 1uw6P-3wv4A:
20.80
1uw6Q-3wv4A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		4 / 8 TRP A  55
LEU A 246
MET A  48
TYR A  97
 None
 1.35A 1uw6P-3wv4A:
undetectable
1uw6T-3wv4A:
undetectable		 1uw6P-3wv4A:
20.80
1uw6T-3wv4A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		5 / 11 LEU A 275
LEU A 279
ILE A 271
ALA A 310
LEU A 303
 None
 1.18A 2q72A-3wv4A:
undetectable		 2q72A-3wv4A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QK8_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		4 / 4 MET A  48
LEU A 233
ASN A  88
THR A 240
 None
 1.50A 2qk8A-3wv4A:
0.3		 2qk8A-3wv4A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		4 / 8 ILE A 271
LEU A 261
VAL A 258
LEU A 257
 None
 0.90A 2w98B-3wv4A:
5.2		 2w98B-3wv4A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		5 / 10 THR A 185
TRP A 229
GLY A 325
GLN A 326
THR A 327
 None
 0.96A 2wd9C-3wv4A:
42.3		 2wd9C-3wv4A:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		5 / 11 VAL A 236
LEU A 233
GLY A 232
PRO A  87
THR A  92
 None
 1.29A 3bjwB-3wv4A:
undetectable		 3bjwB-3wv4A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		5 / 11 VAL A 236
LEU A 233
GLY A 232
PRO A  87
THR A  92
 None
 1.27A 3bjwE-3wv4A:
undetectable		 3bjwE-3wv4A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		5 / 12 VAL A 236
LEU A 233
GLY A 232
PRO A  87
THR A  92
 None
 1.22A 3bjwF-3wv4A:
undetectable		 3bjwF-3wv4A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		5 / 11 VAL A 236
LEU A 233
GLY A 232
PRO A  87
THR A  92
 None
 1.30A 3bjwH-3wv4A:
undetectable		 3bjwH-3wv4A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		5 / 12 SER A 239
ILE A 238
LEU A  25
LEU A 213
GLY A 214
 None
 1.07A 3k2hA-3wv4A:
undetectable		 3k2hA-3wv4A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		5 / 12 SER A 239
ILE A 238
LEU A  25
LEU A 213
GLY A 214
 None
 1.04A 3k2hB-3wv4A:
undetectable		 3k2hB-3wv4A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		 3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		3 / 3 PRO A 304
SER A 277
ASN A 298
 None
 0.92A 3lslG-3wv4A:
undetectable		 3lslG-3wv4A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		4 / 5 LYS A 235
VAL A 212
ILE A 238
ARG A 322
 None
 1.28A 3oezA-3wv4A:
undetectable		 3oezA-3wv4A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		4 / 5 LYS A 235
VAL A 212
ILE A 238
ARG A 322
 None
 1.43A 3pyyB-3wv4A:
undetectable		 3pyyB-3wv4A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		3 / 3 THR A 409
VAL A 376
GLU A 328
 None
 0.70A 3v4tA-3wv4A:
undetectable
3v4tD-3wv4A:
undetectable		 3v4tA-3wv4A:
24.17
3v4tD-3wv4A:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		3 / 3 ASP A 230
ARG A 331
LYS A 330
 None
 1.15A 3wipG-3wv4A:
undetectable		 3wipG-3wv4A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		4 / 6 PHE A 315
PHE A 296
ALA A 266
LEU A 257
 None
 1.05A 4ejgD-3wv4A:
undetectable		 4ejgD-3wv4A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		5 / 12 SER A 239
ILE A 238
LEU A  25
LEU A 213
GLY A 214
 None
 1.14A 4foxG-3wv4A:
undetectable		 4foxG-3wv4A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		4 / 8 ILE A 209
ILE A 202
PHE A 204
GLY A 378
 None
 0.81A 4hdlA-3wv4A:
undetectable		 4hdlA-3wv4A:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		5 / 12 ALA A 171
ASN A  62
LEU A  61
GLY A  39
GLN A  58
 None
 1.13A 4r38A-3wv4A:
undetectable		 4r38A-3wv4A:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		5 / 12 ALA A 171
ASN A  62
LEU A  61
GLY A  39
GLN A  58
 None
 1.18A 4r38B-3wv4A:
undetectable		 4r38B-3wv4A:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		5 / 12 ALA A 171
ASN A  62
LEU A  61
GLY A  39
GLN A  58
 None
 1.17A 4r38C-3wv4A:
undetectable		 4r38C-3wv4A:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		3 / 3 GLU A 373
HIS A 408
ASP A 360
 None
 0.74A 5c0oG-3wv4A:
2.6		 5c0oG-3wv4A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		3 / 3 THR A 292
THR A 267
PHE A 222
 None
 0.92A 5cxvA-3wv4A:
undetectable		 5cxvA-3wv4A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		3 / 3 HIS A 117
LYS A 114
PHE A 116
 None
 1.43A 5klaA-3wv4A:
undetectable		 5klaA-3wv4A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		5 / 12 SER A  68
VAL A 104
GLY A 103
GLY A  98
HIS A 199
 None
 1.17A 5nnaA-3wv4A:
undetectable		 5nnaA-3wv4A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		5 / 12 SER A  68
VAL A 104
GLY A 103
GLY A  98
HIS A 199
 None
 1.19A 5nnaB-3wv4A:
undetectable		 5nnaB-3wv4A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		5 / 12 SER A  68
VAL A 104
GLY A 103
GLY A  98
HIS A 199
 None
 1.19A 5nnaC-3wv4A:
undetectable		 5nnaC-3wv4A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		5 / 12 SER A  68
VAL A 104
GLY A 103
GLY A  98
HIS A 199
 None
 1.17A 5nnaD-3wv4A:
undetectable		 5nnaD-3wv4A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		3 / 3 HIS A  63
GLU A  59
TRP A  55
 None
 0.87A 5odqD-3wv4A:
undetectable		 5odqD-3wv4A:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OJ0_A_9WTA801_0
(PENICILLIN-BINDING
PROTEIN 2X)		 3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		5 / 12 ARG A  90
SER A  45
THR A  42
GLY A 243
THR A 240
 None
 1.39A 5oj0A-3wv4A:
undetectable		 5oj0A-3wv4A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		5 / 10 LEU A 351
SER A 208
LEU A  25
ILE A 334
PRO A 336
 None
 1.46A 6dlzB-3wv4A:
4.5
6dlzC-3wv4A:
4.6		 6dlzB-3wv4A:
15.05
6dlzC-3wv4A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		5 / 11 ILE A 334
PRO A 336
LEU A 351
SER A 208
LEU A  25
 None
 1.45A 6dlzA-3wv4A:
5.2
6dlzD-3wv4A:
5.1		 6dlzA-3wv4A:
15.05
6dlzD-3wv4A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		5 / 10 LEU A 351
SER A 208
LEU A  25
ILE A 334
PRO A 336
 None
 1.45A 6dm1B-3wv4A:
5.2
6dm1C-3wv4A:
4.4		 6dm1B-3wv4A:
15.05
6dm1C-3wv4A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		5 / 11 ILE A 334
PRO A 336
LEU A 351
SER A 208
LEU A  25
 None
 1.45A 6dm1A-3wv4A:
3.7
6dm1D-3wv4A:
4.9		 6dm1A-3wv4A:
15.05
6dm1D-3wv4A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		5 / 10 LEU A 351
SER A 208
LEU A  25
ILE A 334
PRO A 336
 None
 1.47A 6dm2B-3wv4A:
4.2
6dm2C-3wv4A:
5.3		 6dm2B-3wv4A:
15.05
6dm2C-3wv4A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		5 / 10 ILE A 334
PRO A 336
LEU A 351
SER A 208
LEU A  25
 None
 1.47A 6dm2A-3wv4A:
5.3
6dm2D-3wv4A:
5.3		 6dm2A-3wv4A:
15.05
6dm2D-3wv4A:
15.05