SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wv7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 3wv7 HMD CO-OCCURRING
PROTEIN HCGE
(Methanothermobac
ter
marburgensis) 		5 / 12 GLY A  25
GLY A  22
ILE A 109
VAL A  19
LEU A  18
 None
ADP  A 301 (-3.2A)
ADP  A 301 (-3.8A)
ADP  A 301 ( 4.9A)
None
 0.94A 2yqzA-3wv7A:
6.3		 2yqzA-3wv7A:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3wv7 HMD CO-OCCURRING
PROTEIN HCGE
(Methanothermobac
ter
marburgensis) 		6 / 12 GLY A 137
GLY A 176
SER A 147
VAL A 149
LEU A 174
LEU A 180
 None
 1.39A 3cjtO-3wv7A:
5.5		 3cjtO-3wv7A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 3wv7 HMD CO-OCCURRING
PROTEIN HCGE
(Methanothermobac
ter
marburgensis) 		4 / 4 VAL A 175
ARG A  27
ILE A 109
THR A 177
 None
None
ADP  A 301 (-3.8A)
None
 1.33A 3cl9A-3wv7A:
undetectable		 3cl9A-3wv7A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_1
(PROTEASE)		 3wv7 HMD CO-OCCURRING
PROTEIN HCGE
(Methanothermobac
ter
marburgensis) 		5 / 12 GLY A 137
ILE A 133
ILE A 109
THR A  28
VAL A 195
 None
None
ADP  A 301 (-3.8A)
None
None
 0.92A 3el4A-3wv7A:
undetectable		 3el4A-3wv7A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 3wv7 HMD CO-OCCURRING
PROTEIN HCGE
(Methanothermobac
ter
marburgensis) 		3 / 3 GLU A 108
VAL A  19
CYH A 106
 None
ADP  A 301 ( 4.9A)
None
 1.02A 3fbxA-3wv7A:
undetectable		 3fbxA-3wv7A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 3wv7 HMD CO-OCCURRING
PROTEIN HCGE
(Methanothermobac
ter
marburgensis) 		3 / 3 GLU A 108
VAL A 107
CYH A 106
 None
 1.07A 3fbxA-3wv7A:
undetectable		 3fbxA-3wv7A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_A_T3A1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 3wv7 HMD CO-OCCURRING
PROTEIN HCGE
(Methanothermobac
ter
marburgensis) 		5 / 12 VAL A 138
GLY A 176
VAL A 146
ARG A  27
GLU A 108
 None
 1.43A 4bvaA-3wv7A:
6.2		 4bvaA-3wv7A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 3wv7 HMD CO-OCCURRING
PROTEIN HCGE
(Methanothermobac
ter
marburgensis) 		5 / 11 ILE A 121
ILE A 100
ALA A 130
ALA A 131
VAL A  19
 None
None
None
None
ADP  A 301 ( 4.9A)
 1.08A 4h1nA-3wv7A:
undetectable		 4h1nA-3wv7A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3wv7 HMD CO-OCCURRING
PROTEIN HCGE
(Methanothermobac
ter
marburgensis) 		4 / 7 LEU A 180
THR A 135
THR A 114
LEU A 115
 None
 0.94A 4z91F-3wv7A:
undetectable
4z91G-3wv7A:
undetectable
4z91H-3wv7A:
undetectable
4z91I-3wv7A:
undetectable
4z91J-3wv7A:
undetectable		 4z91F-3wv7A:
23.10
4z91G-3wv7A:
23.10
4z91H-3wv7A:
23.10
4z91I-3wv7A:
23.10
4z91J-3wv7A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3wv7 HMD CO-OCCURRING
PROTEIN HCGE
(Methanothermobac
ter
marburgensis) 		5 / 9 PHE A  58
ILE A  57
GLY A  22
LEU A  18
LEU A  32
 None
None
ADP  A 301 (-3.2A)
None
None
 1.42A 4ze0A-3wv7A:
undetectable		 4ze0A-3wv7A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3wv7 HMD CO-OCCURRING
PROTEIN HCGE
(Methanothermobac
ter
marburgensis) 		5 / 11 VAL A 175
GLY A  25
GLY A  22
GLU A 108
ILE A 109
 None
None
ADP  A 301 (-3.2A)
None
ADP  A 301 (-3.8A)
 1.46A 4zvmA-3wv7A:
5.2
4zvmB-3wv7A:
5.6		 4zvmA-3wv7A:
21.18
4zvmB-3wv7A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 3wv7 HMD CO-OCCURRING
PROTEIN HCGE
(Methanothermobac
ter
marburgensis) 		5 / 12 GLY A  20
GLY A  22
THR A  28
ASP A  47
ILE A  92
 ADP  A 301 ( 3.9A)
ADP  A 301 (-3.2A)
None
ADP  A 301 (-2.8A)
ADP  A 301 (-4.6A)
 0.96A 5bw4A-3wv7A:
4.5		 5bw4A-3wv7A:
23.57