SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wva'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3wva UPF0254 PROTEIN
MJ1251
(Methanocaldococc
us
jannaschii) 		3 / 3 SER A  36
GLU A  37
GLU A  38
 None
 0.58A 1eqbD-3wvaA:
undetectable		 1eqbD-3wvaA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3wva UPF0254 PROTEIN
MJ1251
(Methanocaldococc
us
jannaschii) 		3 / 3 SER A  36
GLU A  37
GLU A  38
 None
 0.57A 1eqbB-3wvaA:
undetectable		 1eqbB-3wvaA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 3wva UPF0254 PROTEIN
MJ1251
(Methanocaldococc
us
jannaschii) 		5 / 12 THR A  11
PHE A 129
ALA A  94
ALA A 117
THR A 122
 None
 0.94A 3czhA-3wvaA:
undetectable		 3czhA-3wvaA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 3wva UPF0254 PROTEIN
MJ1251
(Methanocaldococc
us
jannaschii) 		5 / 12 THR A  11
PHE A 129
ALA A  94
ALA A 117
THR A 122
 None
 0.94A 3czhB-3wvaA:
undetectable		 3czhB-3wvaA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 3wva UPF0254 PROTEIN
MJ1251
(Methanocaldococc
us
jannaschii) 		5 / 12 THR A  11
PHE A 129
ALA A  94
ALA A 117
THR A 122
 None
 0.95A 3dl9B-3wvaA:
undetectable		 3dl9B-3wvaA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 3wva UPF0254 PROTEIN
MJ1251
(Methanocaldococc
us
jannaschii) 		3 / 3 THR A 130
SER A 131
ARG A 115
 None
 0.81A 3phnA-3wvaA:
undetectable		 3phnA-3wvaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_D_DXCD92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3wva UPF0254 PROTEIN
MJ1251
(Methanocaldococc
us
jannaschii) 		4 / 5 VAL A  46
GLU A  27
LYS A  32
PHE A 158
 None
 1.27A 3rv5C-3wvaA:
undetectable
3rv5D-3wvaA:
undetectable		 3rv5C-3wvaA:
20.23
3rv5D-3wvaA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3wva UPF0254 PROTEIN
MJ1251
(Methanocaldococc
us
jannaschii) 		4 / 8 ILE A  19
PHE A  35
GLY A 154
ILE A 120
 None
 0.93A 4qogA-3wvaA:
2.3
4qogB-3wvaA:
undetectable		 4qogA-3wvaA:
21.74
4qogB-3wvaA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 3wva UPF0254 PROTEIN
MJ1251
(Methanocaldococc
us
jannaschii) 		5 / 10 ALA A  13
PHE A 158
ILE A 120
VAL A   4
ALA A  51
 None
 1.16A 5nukA-3wvaA:
undetectable		 5nukA-3wvaA:
22.22