SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wvi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 3wvi TYPE-2 RESTRICTION
ENZYME HINDIII
(Haemophilus
influenzae) 		4 / 7 LEU A  78
ALA A  74
LEU A  80
SER A  82
 None
 1.07A 1dvxA-3wviA:
undetectable		 1dvxA-3wviA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 3wvi TYPE-2 RESTRICTION
ENZYME HINDIII
(Haemophilus
influenzae) 		4 / 8 TYR A 218
LEU A 166
LEU A 160
LEU A 165
 None
 0.88A 1eupA-3wviA:
undetectable		 1eupA-3wviA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 3wvi TYPE-2 RESTRICTION
ENZYME HINDIII
(Haemophilus
influenzae) 		4 / 6 LEU A 105
TRP A 192
PHE A  75
VAL A  94
 None
 1.24A 1ibgH-3wviA:
undetectable		 1ibgH-3wviA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 3wvi TYPE-2 RESTRICTION
ENZYME HINDIII
(Haemophilus
influenzae) 		5 / 12 LEU A 180
LEU A 175
LEU A 172
ALA A 173
LEU A 230
 None
 1.15A 1ya3C-3wviA:
undetectable		 1ya3C-3wviA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 3wvi TYPE-2 RESTRICTION
ENZYME HINDIII
(Haemophilus
influenzae) 		4 / 8 GLY A  67
VAL A  70
LEU A  42
ARG A 244
 None
 1.15A 3bgdB-3wviA:
undetectable		 3bgdB-3wviA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 3wvi TYPE-2 RESTRICTION
ENZYME HINDIII
(Haemophilus
influenzae) 		4 / 8 ARG A 244
SER A   3
LEU A  49
PRO A  50
 None
 1.19A 3jq7B-3wviA:
undetectable		 3jq7B-3wviA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3wvi TYPE-2 RESTRICTION
ENZYME HINDIII
(Haemophilus
influenzae) 		4 / 4 LEU A 172
LEU A 178
GLN A  76
GLU A 182
 None
 1.24A 4i41A-3wviA:
undetectable		 4i41A-3wviA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 3wvi TYPE-2 RESTRICTION
ENZYME HINDIII
(Haemophilus
influenzae) 		5 / 12 LEU A 180
LEU A 175
LEU A 172
ALA A 173
LEU A 230
 None
 1.05A 4ltwA-3wviA:
undetectable		 4ltwA-3wviA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 3wvi TYPE-2 RESTRICTION
ENZYME HINDIII
(Haemophilus
influenzae) 		4 / 7 ILE A  31
LEU A  42
GLY A  67
LYS A  65
 None
 0.90A 4z69A-3wviA:
undetectable		 4z69A-3wviA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 3wvi TYPE-2 RESTRICTION
ENZYME HINDIII
(Haemophilus
influenzae) 		4 / 6 LEU A  78
ALA A  74
LEU A  80
SER A  82
 None
 1.05A 5a6iA-3wviA:
undetectable		 5a6iA-3wviA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3wvi TYPE-2 RESTRICTION
ENZYME HINDIII
(Haemophilus
influenzae) 		5 / 10 LEU A 166
SER A 159
LEU A 160
ASP A 161
PRO A 149
 None
 1.42A 6dlzB-3wviA:
undetectable
6dlzC-3wviA:
undetectable		 6dlzB-3wviA:
15.85
6dlzC-3wviA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3wvi TYPE-2 RESTRICTION
ENZYME HINDIII
(Haemophilus
influenzae) 		5 / 11 PRO A 149
LEU A 166
SER A 159
LEU A 160
ASP A 161
 None
 1.42A 6dlzA-3wviA:
undetectable
6dlzD-3wviA:
undetectable		 6dlzA-3wviA:
15.85
6dlzD-3wviA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3wvi TYPE-2 RESTRICTION
ENZYME HINDIII
(Haemophilus
influenzae) 		5 / 10 LEU A 166
SER A 159
LEU A 160
ASP A 161
PRO A 149
 None
 1.42A 6dm1B-3wviA:
undetectable
6dm1C-3wviA:
undetectable		 6dm1B-3wviA:
15.85
6dm1C-3wviA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3wvi TYPE-2 RESTRICTION
ENZYME HINDIII
(Haemophilus
influenzae) 		5 / 11 PRO A 149
LEU A 166
SER A 159
LEU A 160
ASP A 161
 None
 1.41A 6dm1A-3wviA:
undetectable
6dm1D-3wviA:
undetectable		 6dm1A-3wviA:
15.85
6dm1D-3wviA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3wvi TYPE-2 RESTRICTION
ENZYME HINDIII
(Haemophilus
influenzae) 		5 / 10 LEU A 166
SER A 159
LEU A 160
ASP A 161
PRO A 149
 None
 1.45A 6dm2B-3wviA:
undetectable
6dm2C-3wviA:
undetectable		 6dm2B-3wviA:
15.85
6dm2C-3wviA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3wvi TYPE-2 RESTRICTION
ENZYME HINDIII
(Haemophilus
influenzae) 		5 / 10 PRO A 149
LEU A 166
SER A 159
LEU A 160
ASP A 161
 None
 1.45A 6dm2A-3wviA:
undetectable
6dm2D-3wviA:
undetectable		 6dm2A-3wviA:
15.85
6dm2D-3wviA:
15.85