SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wvj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3wvj BETA-GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 SER A 172
ALA A 113
THR A 146
ILE A 118
 None
 0.80A 1c9sI-3wvjA:
undetectable
1c9sJ-3wvjA:
undetectable		 1c9sI-3wvjA:
16.90
1c9sJ-3wvjA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3wvj BETA-GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 ALA A 113
THR A 146
ILE A 118
SER A 172
 None
 0.77A 1c9sU-3wvjA:
undetectable
1c9sV-3wvjA:
undetectable		 1c9sU-3wvjA:
16.90
1c9sV-3wvjA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3wvj BETA-GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		4 / 7 ALA A 113
THR A 146
ILE A 118
SER A 172
 None
 0.77A 1gtnA-3wvjA:
undetectable
1gtnK-3wvjA:
undetectable		 1gtnA-3wvjA:
16.90
1gtnK-3wvjA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3wvj BETA-GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 SER A 172
ALA A 113
THR A 146
ILE A 118
 None
 0.77A 1gtnE-3wvjA:
undetectable
1gtnF-3wvjA:
undetectable		 1gtnE-3wvjA:
16.90
1gtnF-3wvjA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 3wvj BETA-GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 THR A  70
GLU A 236
ASP A 174
 None
 0.77A 1nt2A-3wvjA:
undetectable		 1nt2A-3wvjA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3wvj BETA-GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		4 / 7 ILE A 218
GLY A 217
PRO A  89
ASN A  56
 None
None
None
B3P  A 302 (-3.1A)
 0.97A 1oniG-3wvjA:
undetectable
1oniI-3wvjA:
undetectable		 1oniG-3wvjA:
20.95
1oniI-3wvjA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_I_TRPI81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3wvj BETA-GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 ALA A 113
THR A 146
ILE A 118
SER A 172
 None
 0.78A 1utdI-3wvjA:
undetectable
1utdJ-3wvjA:
undetectable		 1utdI-3wvjA:
16.90
1utdJ-3wvjA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 3wvj BETA-GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 LYS A  65
PRO A  66
SER A  67
 None
 0.49A 4k50I-3wvjA:
undetectable		 4k50I-3wvjA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3wvj BETA-GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		4 / 7 GLU A  50
THR A  97
LEU A  78
SER A  46
 None
 1.14A 4pfjA-3wvjA:
undetectable		 4pfjA-3wvjA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 3wvj BETA-GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		4 / 6 PHE A 169
PHE A 141
GLU A 107
VAL A 108
 None
 1.18A 5h4dA-3wvjA:
undetectable		 5h4dA-3wvjA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3wvj BETA-GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 TYR A 103
PHE A 180
ILE A 187
THR A 126
THR A  31
 None
 1.35A 5jlcA-3wvjA:
undetectable		 5jlcA-3wvjA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 3wvj BETA-GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ASN A 213
LEU A 214
GLY A  93
VAL A  69
MET A  76
 B3P  A 302 (-3.6A)
None
None
None
None
 1.11A 5uc1B-3wvjA:
undetectable		 5uc1B-3wvjA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3wvj BETA-GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 ASP A 188
ILE A 187
ARG A 198
ASN A 202
 None
 1.25A 6hisA-3wvjA:
undetectable
6hisB-3wvjA:
undetectable		 6hisA-3wvjA:
16.35
6hisB-3wvjA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3wvj BETA-GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 ASP A 188
ILE A 187
ARG A 198
ASN A 202
 None
 1.25A 6hisB-3wvjA:
undetectable
6hisC-3wvjA:
undetectable		 6hisB-3wvjA:
16.35
6hisC-3wvjA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3wvj BETA-GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 ASP A 188
ILE A 187
ARG A 198
ASN A 202
 None
 1.24A 6hisD-3wvjA:
undetectable
6hisE-3wvjA:
undetectable		 6hisD-3wvjA:
16.35
6hisE-3wvjA:
16.35