SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wvn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9J_H_TESH1010_1
(RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT LIGHT
CHAIN)		 3wvn NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		5 / 11 SER A  64
VAL A  93
GLY A  39
LEU A  61
VAL A  31
 None
 1.19A 1i9jH-3wvnA:
undetectable
1i9jL-3wvnA:
undetectable		 1i9jH-3wvnA:
18.78
1i9jL-3wvnA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3wvn NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		4 / 6 LYS A 235
VAL A 212
ILE A 238
ARG A 322
 None
 1.11A 1iepA-3wvnA:
undetectable		 1iepA-3wvnA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3wvn NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		4 / 8 TYR A  97
TRP A  55
LEU A 246
MET A  48
 None
 1.38A 1uw6A-3wvnA:
undetectable
1uw6B-3wvnA:
undetectable		 1uw6A-3wvnA:
18.36
1uw6B-3wvnA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3wvn NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		4 / 8 TYR A  97
TRP A  55
LEU A 246
MET A  48
 None
 1.38A 1uw6D-3wvnA:
undetectable
1uw6E-3wvnA:
undetectable		 1uw6D-3wvnA:
18.36
1uw6E-3wvnA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3wvn NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		4 / 8 TYR A  97
TRP A  55
LEU A 246
MET A  48
 None
 1.40A 1uw6G-3wvnA:
undetectable
1uw6H-3wvnA:
undetectable		 1uw6G-3wvnA:
18.36
1uw6H-3wvnA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3wvn NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		4 / 8 TYR A  97
TRP A  55
LEU A 246
MET A  48
 None
 1.39A 1uw6P-3wvnA:
undetectable
1uw6Q-3wvnA:
undetectable		 1uw6P-3wvnA:
18.36
1uw6Q-3wvnA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3wvn NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		3 / 3 THR A 297
ASP A 230
SER A 228
 None
ASP  A 601 (-2.6A)
None
 0.84A 2nxeB-3wvnA:
3.4		 2nxeB-3wvnA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 3wvn NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		5 / 11 LEU A 275
LEU A 279
ILE A 271
ALA A 310
LEU A 303
 None
 1.22A 2q72A-3wvnA:
undetectable		 2q72A-3wvnA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QK8_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 3wvn NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		4 / 4 MET A  48
LEU A 233
ASN A  88
THR A 240
 None
 1.48A 2qk8A-3wvnA:
0.0		 2qk8A-3wvnA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 3wvn NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		4 / 8 ILE A 271
LEU A 261
VAL A 258
LEU A 257
 None
 0.90A 2w98B-3wvnA:
3.6		 2w98B-3wvnA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 3wvn NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		5 / 10 THR A 185
TRP A 229
GLY A 325
GLN A 326
THR A 327
 None
ASP  A 601 ( 4.9A)
ASP  A 601 (-3.6A)
None
ASP  A 601 (-4.6A)
 1.04A 2wd9C-3wvnA:
42.6		 2wd9C-3wvnA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 3wvn NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		5 / 11 VAL A 236
LEU A 233
GLY A 232
PRO A  87
THR A  92
 None
 1.26A 3bjwB-3wvnA:
undetectable		 3bjwB-3wvnA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 3wvn NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		5 / 11 VAL A 236
LEU A 233
GLY A 232
PRO A  87
THR A  92
 None
 1.23A 3bjwE-3wvnA:
undetectable		 3bjwE-3wvnA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 3wvn NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		5 / 12 VAL A 236
LEU A 233
GLY A 232
PRO A  87
THR A  92
 None
 1.19A 3bjwF-3wvnA:
undetectable		 3bjwF-3wvnA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 3wvn NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		5 / 11 VAL A 236
LEU A 233
GLY A 232
PRO A  87
THR A  92
 None
 1.27A 3bjwH-3wvnA:
undetectable		 3bjwH-3wvnA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3wvn NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		5 / 12 SER A 239
ILE A 238
LEU A  25
LEU A 213
GLY A 214
 None
 1.15A 3k2hA-3wvnA:
undetectable		 3k2hA-3wvnA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3wvn NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		5 / 12 SER A 239
ILE A 238
LEU A  25
LEU A 213
GLY A 214
 None
 1.12A 3k2hB-3wvnA:
undetectable		 3k2hB-3wvnA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3wvn NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		4 / 7 LYS A 235
VAL A 212
ILE A 238
ARG A 322
 None
 1.05A 3mssB-3wvnA:
undetectable		 3mssB-3wvnA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3wvn NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		4 / 5 LYS A 235
VAL A 212
ILE A 238
ARG A 322
 None
 1.25A 3oezA-3wvnA:
undetectable		 3oezA-3wvnA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3wvn NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		3 / 3 THR A 409
VAL A 376
GLU A 328
 None
 0.71A 3v4tA-3wvnA:
undetectable
3v4tD-3wvnA:
undetectable		 3v4tA-3wvnA:
23.67
3v4tD-3wvnA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3wvn NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		3 / 3 ASP A 230
ARG A 331
LYS A 330
 ASP  A 601 (-2.6A)
ASP  A 601 (-3.5A)
ASP  A 601 (-2.9A)
 1.25A 3wipG-3wvnA:
undetectable		 3wipG-3wvnA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 3wvn NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		5 / 12 SER A 239
ILE A 238
LEU A  25
LEU A 213
GLY A 214
 None
 1.21A 4foxG-3wvnA:
undetectable		 4foxG-3wvnA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 3wvn NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		4 / 8 ILE A 209
ILE A 202
PHE A 204
GLY A 378
 None
 0.83A 4hdlA-3wvnA:
undetectable		 4hdlA-3wvnA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME
KP18CYS PEPTIDE)		 3wvn NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		5 / 12 GLU A 133
GLN A  85
LEU A 118
ILE A 122
LEU A 147
 None
 1.44A 4k38A-3wvnA:
undetectable
4k38D-3wvnA:
undetectable		 4k38A-3wvnA:
19.19
4k38D-3wvnA:
2.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 3wvn NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		5 / 12 GLU A 133
GLN A  85
LEU A 118
ILE A 122
LEU A 147
 None
 1.46A 4k38B-3wvnA:
undetectable		 4k38B-3wvnA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 3wvn NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		5 / 12 SER A  68
VAL A 104
GLY A 103
GLY A  98
HIS A 199
 None
 1.21A 5nnaD-3wvnA:
undetectable		 5nnaD-3wvnA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 3wvn NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		3 / 3 HIS A  63
GLU A  59
TRP A  55
 None
 0.84A 5odqD-3wvnA:
undetectable		 5odqD-3wvnA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3wvn NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		4 / 6 GLY A 232
TYR A 234
LEU A 246
VAL A  93
 None
 0.99A 5x80A-3wvnA:
undetectable
5x80B-3wvnA:
undetectable		 5x80A-3wvnA:
16.48
5x80B-3wvnA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3wvn NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		5 / 9 ALA A 205
ILE A 209
PHE A 231
GLY A 232
SER A 239
 None
None
ASP  A 601 ( 4.8A)
None
None
 1.24A 6awoA-3wvnA:
undetectable		 6awoA-3wvnA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3wvn NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		5 / 9 ALA A 205
ILE A 209
PHE A 231
GLY A 232
SER A 239
 None
None
ASP  A 601 ( 4.8A)
None
None
 1.24A 6awqA-3wvnA:
undetectable		 6awqA-3wvnA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3wvn NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		5 / 10 LEU A 351
SER A 208
LEU A  25
ILE A 334
PRO A 336
 None
 1.47A 6dlzB-3wvnA:
5.2
6dlzC-3wvnA:
4.9		 6dlzB-3wvnA:
9.71
6dlzC-3wvnA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3wvn NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		5 / 10 LEU A 351
SER A 208
LEU A  25
ILE A 334
PRO A 336
 None
 1.47A 6dm1B-3wvnA:
5.4
6dm1C-3wvnA:
4.8		 6dm1B-3wvnA:
9.71
6dm1C-3wvnA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3wvn NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		5 / 10 LEU A 351
SER A 208
LEU A  25
ILE A 334
PRO A 336
 None
 1.49A 6dm2B-3wvnA:
5.4
6dm2C-3wvnA:
5.2		 6dm2B-3wvnA:
9.71
6dm2C-3wvnA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3wvn NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
halstedii) 		5 / 10 ILE A 334
PRO A 336
LEU A 351
SER A 208
LEU A  25
 None
 1.48A 6dm2A-3wvnA:
4.7
6dm2D-3wvnA:
5.5		 6dm2A-3wvnA:
9.71
6dm2D-3wvnA:
9.71