SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wvo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		4 / 7 CYH A 258
ASP A  64
GLY A  67
GLY A  68
 None
 0.96A 1ekjE-3wvoA:
undetectable
1ekjF-3wvoA:
undetectable		 1ekjE-3wvoA:
17.17
1ekjF-3wvoA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		4 / 5 LEU A 415
GLU A 373
ALA A 404
LEU A 474
 None
 1.21A 1eta1-3wvoA:
undetectable		 1eta1-3wvoA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		4 / 5 ILE A 420
ARG A 417
ASP A 360
ASN A 224
 None
 1.34A 1kiaD-3wvoA:
undetectable		 1kiaD-3wvoA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MSK_A_SAMA1301_0
(COBALAMIN-DEPENDENT
METHIONINE SYNTHASE)		 3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		5 / 10 GLU A 249
ARG A 232
PRO A 233
ALA A 234
ALA A  60
 None
 1.28A 1mskA-3wvoA:
0.5		 1mskA-3wvoA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		5 / 12 GLU A  70
GLY A  68
GLY A  67
ASP A 221
ASN A 295
 None
 0.96A 1n2xB-3wvoA:
undetectable		 1n2xB-3wvoA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		4 / 4 ILE A 420
ARG A 417
ASP A 360
ASN A 224
 None
 1.33A 1nbiC-3wvoA:
undetectable		 1nbiC-3wvoA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		4 / 4 ILE A 420
ARG A 417
ASP A 360
ASN A 224
 None
 1.32A 1nbiD-3wvoA:
undetectable		 1nbiD-3wvoA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TD2_A_PXLA288_1
(PYRIDOXAMINE KINASE)		 3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		5 / 10 ALA A 134
HIS A 164
GLN A  50
VAL A  47
ASP A 135
 None
 1.49A 1td2A-3wvoA:
undetectable		 1td2A-3wvoA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		4 / 5 GLU A  70
PRO A  69
ILE A  66
GLY A  67
 None
 0.77A 2qeuA-3wvoA:
2.4
2qeuC-3wvoA:
2.5		 2qeuA-3wvoA:
15.27
2qeuC-3wvoA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)		 3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		3 / 3 LYS A 310
ARG A 304
VAL A 317
 None
 1.10A 2r2vC-3wvoA:
undetectable
2r2vD-3wvoA:
undetectable		 2r2vC-3wvoA:
6.00
2r2vD-3wvoA:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		5 / 10 LEU A 408
LEU A 471
LEU A 333
VAL A 337
THR A 379
 None
 1.05A 2w9gA-3wvoA:
undetectable		 2w9gA-3wvoA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		5 / 12 LEU A 214
PHE A 220
HIS A  63
LEU A 257
TYR A 261
 None
 1.45A 3adsA-3wvoA:
undetectable		 3adsA-3wvoA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		5 / 11 LEU A 408
LEU A 471
LEU A 333
VAL A 337
THR A 379
 None
 1.03A 3frbX-3wvoA:
undetectable		 3frbX-3wvoA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		5 / 12 LEU A 213
LEU A  10
LEU A  30
ALA A 156
ALA A 159
 None
 0.84A 3vw7A-3wvoA:
undetectable		 3vw7A-3wvoA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		5 / 12 PHE A  34
LEU A  10
LEU A  30
ALA A 156
ALA A 159
 None
 0.99A 3vw7A-3wvoA:
undetectable		 3vw7A-3wvoA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		5 / 11 GLN A 316
ARG A 357
ASN A 224
ALA A 335
GLY A 339
 None
 1.27A 4a6nA-3wvoA:
undetectable		 4a6nA-3wvoA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		 3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		5 / 12 TRP A 470
LEU A 407
ALA A 422
GLY A 334
GLY A 339
 None
 1.15A 4hfpB-3wvoA:
undetectable		 4hfpB-3wvoA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		5 / 11 ASN A 216
LEU A 213
LEU A 209
LEU A  58
LEU A  43
 None
 1.13A 4wg0F-3wvoA:
undetectable
4wg0G-3wvoA:
undetectable
4wg0H-3wvoA:
undetectable		 4wg0F-3wvoA:
12.99
4wg0G-3wvoA:
12.99
4wg0H-3wvoA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		4 / 8 LEU A  43
THR A 212
LEU A 213
LEU A 209
 None
 0.79A 4z90F-3wvoA:
6.1
4z90G-3wvoA:
6.1
4z90H-3wvoA:
5.9
4z90I-3wvoA:
6.0
4z90J-3wvoA:
5.7		 4z90F-3wvoA:
20.11
4z90G-3wvoA:
20.11
4z90H-3wvoA:
20.11
4z90I-3wvoA:
20.11
4z90J-3wvoA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA602_1
(SERUM ALBUMIN)		 3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		4 / 8 LEU A 463
ASP A 425
ALA A 429
VAL A 432
 None
 0.90A 4zbqA-3wvoA:
2.8		 4zbqA-3wvoA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		5 / 7 ILE A 420
LEU A 333
GLU A 427
GLY A 332
GLY A 334
 None
 1.38A 5a06A-3wvoA:
undetectable		 5a06A-3wvoA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		5 / 7 ILE A 420
LEU A 333
GLU A 427
GLY A 332
GLY A 334
 None
 1.37A 5a06C-3wvoA:
undetectable		 5a06C-3wvoA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		5 / 7 ILE A 420
LEU A 333
GLU A 427
GLY A 332
GLY A 334
 None
 1.37A 5a06E-3wvoA:
undetectable		 5a06E-3wvoA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		5 / 12 ASP A 374
ALA A 475
GLY A 414
SER A 413
GLU A 410
 None
 1.24A 5hfjE-3wvoA:
undetectable		 5hfjE-3wvoA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		4 / 6 ARG A  56
GLY A 201
THR A 300
GLU A 297
 None
 1.08A 5ny7A-3wvoA:
undetectable		 5ny7A-3wvoA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		4 / 8 PRO A 290
GLN A 308
VAL A 193
GLY A 192
 None
 0.81A 5nzyA-3wvoA:
undetectable		 5nzyA-3wvoA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11802_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
UL4
RIBOSOMAL PROTEIN
UL15
RIBOSOMAL PROTEIN
EL15)		 3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		3 / 3 ARG A 303
LYS A 310
ARG A 321
 None
 1.37A 6az3C-3wvoA:
1.1
6az3L-3wvoA:
undetectable
6az3M-3wvoA:
undetectable		 6az3C-3wvoA:
8.78
6az3L-3wvoA:
8.66
6az3M-3wvoA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		5 / 11 GLU A 249
ARG A 232
PRO A 233
ALA A 234
ALA A  60
 None
 1.34A 6bm5A-3wvoA:
undetectable		 6bm5A-3wvoA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)		 3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		4 / 8 LEU A 474
GLU A 482
THR A 418
TRP A 470
 None
 1.10A 6c71B-3wvoA:
undetectable		 6c71B-3wvoA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		6 / 11 LEU A 213
GLY A  68
ILE A  66
PHE A  34
ILE A  93
ILE A  61
 None
 1.44A 6ebzA-3wvoA:
3.3		 6ebzA-3wvoA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		6 / 11 LEU A 213
GLY A  68
ILE A  66
PHE A  34
ILE A  93
ILE A  61
 None
 1.42A 6ebzB-3wvoA:
undetectable		 6ebzB-3wvoA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		6 / 11 LEU A 213
GLY A  68
ILE A  66
PHE A  34
ILE A  93
ILE A  61
 None
 1.44A 6ebzC-3wvoA:
undetectable		 6ebzC-3wvoA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		6 / 11 LEU A 213
GLY A  68
ILE A  66
PHE A  34
ILE A  93
ILE A  61
 None
 1.41A 6ebzD-3wvoA:
undetectable		 6ebzD-3wvoA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA824_0
(GEPHYRIN)		 3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		4 / 4 LEU A 288
ASP A 259
PRO A 254
ARG A 253
 None
 1.31A 6fgdA-3wvoA:
undetectable		 6fgdA-3wvoA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		4 / 5 TYR A 168
ILE A  61
MET A 299
GLY A 201
 None
 0.94A 6hd6A-3wvoA:
undetectable		 6hd6A-3wvoA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		3 / 3 ASP A 247
LEU A 250
ARG A 267
 None
 0.86A 7dfrA-3wvoA:
undetectable		 7dfrA-3wvoA:
14.74