SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wvr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3wvr PGM1
(Streptomyces
cirratus) 		5 / 12 ALA A 150
LEU A 302
SER A 141
ILE A 138
LEU A 309
 None
 1.19A 1ddsB-3wvrA:
undetectable		 1ddsB-3wvrA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 3wvr PGM1
(Streptomyces
cirratus) 		3 / 4 VAL A  28
TRP A  22
TRP A  29
 None
SO4  A 501 (-4.8A)
None
 1.26A 1gmkA-3wvrA:
undetectable
1gmkB-3wvrA:
undetectable		 1gmkA-3wvrA:
5.12
1gmkB-3wvrA:
5.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 3wvr PGM1
(Streptomyces
cirratus) 		4 / 8 GLU A 270
LEU A 419
ALA A 422
LEU A 423
 None
 0.90A 1hwiB-3wvrA:
2.3		 1hwiB-3wvrA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 3wvr PGM1
(Streptomyces
cirratus) 		4 / 8 GLU A 270
LEU A 419
ALA A 422
LEU A 423
 None
 0.91A 1hwiD-3wvrA:
2.2		 1hwiD-3wvrA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 3wvr PGM1
(Streptomyces
cirratus) 		4 / 8 GLU A 270
LEU A 419
ALA A 422
LEU A 423
 None
 0.91A 1hwiC-3wvrA:
2.4		 1hwiC-3wvrA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_A_BEZA1501_0
(ANTHRANILATE
SYNTHASE)		 3wvr PGM1
(Streptomyces
cirratus) 		5 / 11 GLU A 234
GLY A 191
LEU A  13
GLU A 331
LYS A 142
 None
 1.50A 1i7qA-3wvrA:
undetectable		 1i7qA-3wvrA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 3wvr PGM1
(Streptomyces
cirratus) 		5 / 12 LEU A 315
LEU A 306
VAL A 154
ALA A 144
ALA A 147
 None
 1.23A 1n5xA-3wvrA:
2.0		 1n5xA-3wvrA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 3wvr PGM1
(Streptomyces
cirratus) 		5 / 12 LEU A 315
LEU A 306
VAL A 154
ALA A 144
ALA A 147
 None
 1.23A 1n5xB-3wvrA:
undetectable		 1n5xB-3wvrA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 3wvr PGM1
(Streptomyces
cirratus) 		5 / 11 LEU A  13
GLU A  12
ALA A 110
LEU A 131
LEU A 137
 None
 1.35A 2c12F-3wvrA:
undetectable		 2c12F-3wvrA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3wvr PGM1
(Streptomyces
cirratus) 		4 / 4 SER A 339
GLY A 338
HIS A 332
ASP A 187
 None
SO4  A 503 (-3.7A)
None
None
 1.27A 2oxtC-3wvrA:
undetectable		 2oxtC-3wvrA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 3wvr PGM1
(Streptomyces
cirratus) 		4 / 8 LEU A 315
PHE A 256
ARG A 301
GLY A 299
 None
 0.88A 2vdbA-3wvrA:
undetectable		 2vdbA-3wvrA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3wvr PGM1
(Streptomyces
cirratus) 		4 / 6 LEU A 119
PHE A  95
LEU A  91
PHE A  87
 None
 0.99A 3abkP-3wvrA:
undetectable
3abkW-3wvrA:
undetectable		 3abkP-3wvrA:
19.19
3abkW-3wvrA:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3wvr PGM1
(Streptomyces
cirratus) 		4 / 8 LEU A 119
PHE A  95
LEU A  91
PHE A  87
 None
 0.93A 3ag4C-3wvrA:
undetectable
3ag4J-3wvrA:
undetectable		 3ag4C-3wvrA:
19.19
3ag4J-3wvrA:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 3wvr PGM1
(Streptomyces
cirratus) 		6 / 9 LEU A 306
ILE A 258
GLY A 313
LEU A 302
GLU A 255
CYH A 303
 None
 1.35A 3ai9X-3wvrA:
undetectable		 3ai9X-3wvrA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 3wvr PGM1
(Streptomyces
cirratus) 		5 / 12 LEU A 315
GLY A 313
ILE A 342
TYR A 311
ASN A 333
 None
 1.14A 3eeoA-3wvrA:
undetectable		 3eeoA-3wvrA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 3wvr PGM1
(Streptomyces
cirratus) 		5 / 12 ALA A 150
LEU A 302
SER A 141
ILE A 138
LEU A 309
 None
 1.43A 3ia4A-3wvrA:
undetectable		 3ia4A-3wvrA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 3wvr PGM1
(Streptomyces
cirratus) 		5 / 9 VAL A 154
GLY A 153
VAL A 327
GLN A 291
GLY A 298
 None
 1.29A 3kmoA-3wvrA:
undetectable		 3kmoA-3wvrA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 3wvr PGM1
(Streptomyces
cirratus) 		5 / 12 LEU A 362
ARG A 272
GLY A 356
THR A 357
LEU A 419
 None
 1.16A 3okxB-3wvrA:
undetectable		 3okxB-3wvrA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3wvr PGM1
(Streptomyces
cirratus) 		4 / 6 TYR A 343
GLN A 280
ILE A 342
SER A 316
 None
 1.14A 3pmzD-3wvrA:
undetectable		 3pmzD-3wvrA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3wvr PGM1
(Streptomyces
cirratus) 		4 / 6 LEU A 119
PHE A  95
LEU A  91
PHE A  87
 None
 0.86A 3wg7C-3wvrA:
undetectable
3wg7J-3wvrA:
undetectable		 3wg7C-3wvrA:
19.19
3wg7J-3wvrA:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		 3wvr PGM1
(Streptomyces
cirratus) 		5 / 10 TYR A  50
LEU A 388
GLY A 396
VAL A 350
VAL A 346
 None
 1.33A 4c9nB-3wvrA:
undetectable		 4c9nB-3wvrA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)		 3wvr PGM1
(Streptomyces
cirratus) 		5 / 9 TYR A  50
LEU A 388
GLY A 396
VAL A 350
VAL A 346
 None
 1.37A 4c9pA-3wvrA:
undetectable		 4c9pA-3wvrA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3wvr PGM1
(Streptomyces
cirratus) 		5 / 12 GLU A  12
ASN A   7
GLY A 136
SER A 134
GLN A 133
 None
 1.42A 4djeB-3wvrA:
undetectable		 4djeB-3wvrA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3wvr PGM1
(Streptomyces
cirratus) 		3 / 3 GLY A 191
SER A 190
TRP A   9
 None
 0.78A 4e7cD-3wvrA:
undetectable		 4e7cD-3wvrA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)		 3wvr PGM1
(Streptomyces
cirratus) 		4 / 5 THR A 357
GLY A 354
VAL A 351
PRO A 353
 None
 1.15A 4grkA-3wvrA:
undetectable		 4grkA-3wvrA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		 3wvr PGM1
(Streptomyces
cirratus) 		5 / 12 TYR A 224
LEU A 232
ALA A 211
GLY A 194
GLY A 189
 None
 1.29A 4hfpB-3wvrA:
undetectable		 4hfpB-3wvrA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3wvr PGM1
(Streptomyces
cirratus) 		6 / 12 VAL A  64
LEU A  39
VAL A  51
LEU A  48
ALA A  31
LEU A  27
 None
 1.44A 4o1zB-3wvrA:
undetectable		 4o1zB-3wvrA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3wvr PGM1
(Streptomyces
cirratus) 		5 / 12 ALA A 150
LEU A 302
SER A 141
ILE A 138
LEU A 309
 None
 1.15A 4qi9A-3wvrA:
undetectable		 4qi9A-3wvrA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3wvr PGM1
(Streptomyces
cirratus) 		5 / 12 ALA A 150
LEU A 302
SER A 141
ILE A 138
LEU A 309
 None
 1.13A 4qi9B-3wvrA:
undetectable		 4qi9B-3wvrA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3wvr PGM1
(Streptomyces
cirratus) 		4 / 7 LEU A 119
PHE A  95
LEU A  91
PHE A  87
 None
 0.92A 5b1aC-3wvrA:
undetectable
5b1aJ-3wvrA:
undetectable		 5b1aC-3wvrA:
19.19
5b1aJ-3wvrA:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3wvr PGM1
(Streptomyces
cirratus) 		4 / 7 LEU A 119
PHE A  95
LEU A  91
PHE A  87
 None
 0.93A 5b1aP-3wvrA:
undetectable
5b1aW-3wvrA:
undetectable		 5b1aP-3wvrA:
19.19
5b1aW-3wvrA:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3wvr PGM1
(Streptomyces
cirratus) 		4 / 7 LEU A 119
PHE A  95
LEU A  91
PHE A  87
 None
 0.95A 5iy5C-3wvrA:
undetectable
5iy5J-3wvrA:
undetectable		 5iy5C-3wvrA:
18.78
5iy5J-3wvrA:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3wvr PGM1
(Streptomyces
cirratus) 		3 / 3 VAL A 240
HIS A 169
VAL A 172
 None
 0.39A 5jmnC-3wvrA:
undetectable		 5jmnC-3wvrA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		 3wvr PGM1
(Streptomyces
cirratus) 		3 / 3 THR A 337
SER A 339
TYR A 343
 SO4  A 503 (-3.7A)
None
None
 0.89A 5jseA-3wvrA:
undetectable		 5jseA-3wvrA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_2
(PROTEASE)		 3wvr PGM1
(Streptomyces
cirratus) 		6 / 12 LEU A 212
GLY A 208
ALA A 209
PRO A 181
SER A 199
ILE A 197
 None
 1.42A 5t2zB-3wvrA:
undetectable		 5t2zB-3wvrA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 3wvr PGM1
(Streptomyces
cirratus) 		5 / 12 VAL A   5
PHE A  95
LEU A  88
LEU A 119
VAL A 100
 None
 1.15A 5tudA-3wvrA:
undetectable		 5tudA-3wvrA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 3wvr PGM1
(Streptomyces
cirratus) 		3 / 3 GLY A 334
LEU A 315
HIS A 332
 None
 0.69A 5u63B-3wvrA:
undetectable		 5u63B-3wvrA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 3wvr PGM1
(Streptomyces
cirratus) 		3 / 3 ARG A 174
ARG A 146
ARG A 244
 None
 0.76A 6bplA-3wvrA:
undetectable
6bplB-3wvrA:
undetectable		 6bplA-3wvrA:
13.25
6bplB-3wvrA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 3wvr PGM1
(Streptomyces
cirratus) 		5 / 12 VAL A   5
VAL A  38
GLY A  70
THR A  20
GLY A  21
 None
None
None
SO4  A 501 (-3.3A)
SO4  A 501 (-4.0A)
 1.19A 6brdC-3wvrA:
undetectable		 6brdC-3wvrA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 3wvr PGM1
(Streptomyces
cirratus) 		3 / 3 TYR A 224
ALA A 168
LEU A 184
 None
 0.65A 6d9kF-3wvrA:
undetectable		 6d9kF-3wvrA:
21.53