SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wvs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_B_DVAB8_0
(GRAMICIDIN A)		 3wvs PUTATIVE
MONOOXYGENASE
(Streptomyces
sp.
SN-593) 		3 / 3 VAL A 314
VAL A  41
TRP A  50
 None
 0.97A 1av2A-3wvsA:
undetectable
1av2B-3wvsA:
undetectable		 1av2A-3wvsA:
6.22
1av2B-3wvsA:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 3wvs PUTATIVE
MONOOXYGENASE
(Streptomyces
sp.
SN-593) 		4 / 6 LEU A  38
ILE A 344
TYR A  29
VAL A  61
 None
 0.97A 1db1A-3wvsA:
undetectable		 1db1A-3wvsA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 3wvs PUTATIVE
MONOOXYGENASE
(Streptomyces
sp.
SN-593) 		3 / 3 PHE A  17
LEU A  43
SER A 291
 None
 0.63A 1e7aA-3wvsA:
1.1		 1e7aA-3wvsA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9J_H_TESH1010_1
(RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT LIGHT
CHAIN)		 3wvs PUTATIVE
MONOOXYGENASE
(Streptomyces
sp.
SN-593) 		5 / 11 VAL A 391
GLY A  22
LEU A  23
VAL A 142
PRO A 251
 None
 1.34A 1i9jH-3wvsA:
undetectable
1i9jL-3wvsA:
undetectable		 1i9jH-3wvsA:
20.73
1i9jL-3wvsA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3wvs PUTATIVE
MONOOXYGENASE
(Streptomyces
sp.
SN-593) 		4 / 8 LEU A  60
ASP A  57
LEU A  38
GLY A  37
 None
 0.93A 1n13A-3wvsA:
undetectable
1n13F-3wvsA:
undetectable		 1n13A-3wvsA:
10.00
1n13F-3wvsA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 3wvs PUTATIVE
MONOOXYGENASE
(Streptomyces
sp.
SN-593) 		3 / 3 VAL A 314
VAL A  41
TRP A  50
 None
 0.99A 1w5uA-3wvsA:
undetectable
1w5uB-3wvsA:
undetectable		 1w5uA-3wvsA:
6.22
1w5uB-3wvsA:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 3wvs PUTATIVE
MONOOXYGENASE
(Streptomyces
sp.
SN-593) 		5 / 10 ALA A  52
THR A  53
ALA A 321
VAL A 314
GLY A 304
 None
 0.87A 2f16K-3wvsA:
undetectable
2f16L-3wvsA:
undetectable		 2f16K-3wvsA:
19.85
2f16L-3wvsA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 3wvs PUTATIVE
MONOOXYGENASE
(Streptomyces
sp.
SN-593) 		5 / 10 ALA A  52
THR A  53
ALA A 321
VAL A 314
GLY A 304
 None
 0.87A 2f16Y-3wvsA:
undetectable
2f16Z-3wvsA:
undetectable		 2f16Y-3wvsA:
19.85
2f16Z-3wvsA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)		 3wvs PUTATIVE
MONOOXYGENASE
(Streptomyces
sp.
SN-593) 		3 / 3 VAL A  41
TRP A  50
VAL A 314
 None
 0.90A 2izqC-3wvsA:
undetectable
2izqD-3wvsA:
undetectable		 2izqC-3wvsA:
6.22
2izqD-3wvsA:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 3wvs PUTATIVE
MONOOXYGENASE
(Streptomyces
sp.
SN-593) 		5 / 11 MET A 397
LEU A 374
LEU A 377
LEU A 258
ILE A 129
 None
 1.26A 2qd3A-3wvsA:
undetectable		 2qd3A-3wvsA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 3wvs PUTATIVE
MONOOXYGENASE
(Streptomyces
sp.
SN-593) 		5 / 10 ALA A  58
LEU A  38
VAL A 314
ILE A 301
PHE A  67
 None
 1.16A 2w9gA-3wvsA:
undetectable		 2w9gA-3wvsA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 3wvs PUTATIVE
MONOOXYGENASE
(Streptomyces
sp.
SN-593) 		5 / 10 ALA A  58
LEU A  38
VAL A 314
ILE A 301
PHE A  67
 None
 1.12A 2w9hA-3wvsA:
undetectable		 2w9hA-3wvsA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 3wvs PUTATIVE
MONOOXYGENASE
(Streptomyces
sp.
SN-593) 		3 / 3 ALA A 241
THR A 245
CYH A 353
 HEM  A 501 (-3.8A)
HEM  A 501 (-3.3A)
HEM  A 501 (-2.3A)
 0.65A 3e4eA-3wvsA:
30.0		 3e4eA-3wvsA:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 3wvs PUTATIVE
MONOOXYGENASE
(Streptomyces
sp.
SN-593) 		3 / 3 ALA A 241
THR A 245
CYH A 353
 HEM  A 501 (-3.8A)
HEM  A 501 (-3.3A)
HEM  A 501 (-2.3A)
 0.58A 3e4eB-3wvsA:
30.1		 3e4eB-3wvsA:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 3wvs PUTATIVE
MONOOXYGENASE
(Streptomyces
sp.
SN-593) 		5 / 9 ALA A  58
LEU A  38
VAL A 314
ILE A 301
PHE A  67
 None
 1.23A 3freX-3wvsA:
undetectable		 3freX-3wvsA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 3wvs PUTATIVE
MONOOXYGENASE
(Streptomyces
sp.
SN-593) 		5 / 12 LEU A 281
PHE A 284
ILE A 334
LEU A 336
ASP A 337
 None
 1.26A 3ko0G-3wvsA:
undetectable
3ko0H-3wvsA:
undetectable
3ko0I-3wvsA:
undetectable
3ko0J-3wvsA:
undetectable		 3ko0G-3wvsA:
12.56
3ko0H-3wvsA:
12.56
3ko0I-3wvsA:
12.56
3ko0J-3wvsA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 3wvs PUTATIVE
MONOOXYGENASE
(Streptomyces
sp.
SN-593) 		5 / 11 LEU A 336
ASP A 337
LEU A 281
PHE A 284
ILE A 334
 None
 1.26A 3ko0A-3wvsA:
undetectable
3ko0B-3wvsA:
undetectable
3ko0I-3wvsA:
undetectable
3ko0J-3wvsA:
undetectable		 3ko0A-3wvsA:
12.56
3ko0B-3wvsA:
12.56
3ko0I-3wvsA:
12.56
3ko0J-3wvsA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 3wvs PUTATIVE
MONOOXYGENASE
(Streptomyces
sp.
SN-593) 		5 / 12 LEU A 281
PHE A 284
ILE A 334
LEU A 336
ASP A 337
 None
 1.19A 3ko0K-3wvsA:
undetectable
3ko0L-3wvsA:
undetectable
3ko0S-3wvsA:
undetectable
3ko0T-3wvsA:
undetectable		 3ko0K-3wvsA:
12.56
3ko0L-3wvsA:
12.56
3ko0S-3wvsA:
12.56
3ko0T-3wvsA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 3wvs PUTATIVE
MONOOXYGENASE
(Streptomyces
sp.
SN-593) 		5 / 12 LEU A 336
ASP A 337
LEU A 281
PHE A 284
ILE A 334
 None
 1.22A 3ko0K-3wvsA:
undetectable
3ko0L-3wvsA:
undetectable
3ko0M-3wvsA:
undetectable
3ko0N-3wvsA:
undetectable		 3ko0K-3wvsA:
12.56
3ko0L-3wvsA:
12.56
3ko0M-3wvsA:
12.56
3ko0N-3wvsA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 3wvs PUTATIVE
MONOOXYGENASE
(Streptomyces
sp.
SN-593) 		5 / 12 LEU A 281
PHE A 284
ILE A 334
LEU A 336
ASP A 337
 None
 1.14A 3ko0M-3wvsA:
undetectable
3ko0N-3wvsA:
undetectable
3ko0O-3wvsA:
undetectable
3ko0P-3wvsA:
undetectable		 3ko0M-3wvsA:
12.56
3ko0N-3wvsA:
12.56
3ko0O-3wvsA:
12.56
3ko0P-3wvsA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 3wvs PUTATIVE
MONOOXYGENASE
(Streptomyces
sp.
SN-593) 		4 / 6 GLY A 159
MET A 216
ILE A 200
VAL A 160
 None
 1.17A 3kvvA-3wvsA:
undetectable		 3kvvA-3wvsA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)		 3wvs PUTATIVE
MONOOXYGENASE
(Streptomyces
sp.
SN-593) 		4 / 6 GLY A 159
MET A 216
ILE A 200
VAL A 160
 None
 1.14A 3kvvC-3wvsA:
undetectable		 3kvvC-3wvsA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_E_URFE254_1
(URIDINE
PHOSPHORYLASE)		 3wvs PUTATIVE
MONOOXYGENASE
(Streptomyces
sp.
SN-593) 		4 / 6 GLY A 159
MET A 216
ILE A 200
VAL A 160
 None
 1.16A 3kvvE-3wvsA:
undetectable		 3kvvE-3wvsA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 3wvs PUTATIVE
MONOOXYGENASE
(Streptomyces
sp.
SN-593) 		4 / 6 LEU A 273
PRO A 271
ARG A 266
HIS A 263
 None
 1.46A 3ltwA-3wvsA:
undetectable		 3ltwA-3wvsA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3wvs PUTATIVE
MONOOXYGENASE
(Streptomyces
sp.
SN-593) 		5 / 12 LEU A 176
ILE A 240
ALA A 241
GLU A 244
THR A 245
 RRM  A 502 (-4.9A)
RRM  A 502 ( 3.9A)
HEM  A 501 (-3.8A)
None
HEM  A 501 (-3.3A)
 0.73A 3mdvB-3wvsA:
32.3		 3mdvB-3wvsA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 3wvs PUTATIVE
MONOOXYGENASE
(Streptomyces
sp.
SN-593) 		5 / 12 ALA A  52
THR A  53
ALA A 321
VAL A 314
GLY A 304
 None
 0.84A 3mg0Y-3wvsA:
undetectable
3mg0Z-3wvsA:
undetectable		 3mg0Y-3wvsA:
19.85
3mg0Z-3wvsA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 3wvs PUTATIVE
MONOOXYGENASE
(Streptomyces
sp.
SN-593) 		4 / 7 SER A 276
VAL A 278
ARG A 118
GLU A 279
 None
 1.14A 3n5tA-3wvsA:
undetectable
3n5tB-3wvsA:
undetectable		 3n5tA-3wvsA:
22.20
3n5tB-3wvsA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 3wvs PUTATIVE
MONOOXYGENASE
(Streptomyces
sp.
SN-593) 		4 / 7 SER A 276
VAL A 278
ARG A 368
GLU A 279
 None
 1.39A 3n5tA-3wvsA:
undetectable
3n5tB-3wvsA:
undetectable		 3n5tA-3wvsA:
22.20
3n5tB-3wvsA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3wvs PUTATIVE
MONOOXYGENASE
(Streptomyces
sp.
SN-593) 		4 / 8 GLU A 279
SER A 276
VAL A 278
ARG A 118
 None
 1.14A 3nlrA-3wvsA:
undetectable
3nlrB-3wvsA:
undetectable		 3nlrA-3wvsA:
22.04
3nlrB-3wvsA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3wvs PUTATIVE
MONOOXYGENASE
(Streptomyces
sp.
SN-593) 		5 / 12 MET A 397
LEU A 374
LEU A 377
LEU A 258
ILE A 129
 None
 1.27A 4f4dA-3wvsA:
undetectable		 4f4dA-3wvsA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3wvs PUTATIVE
MONOOXYGENASE
(Streptomyces
sp.
SN-593) 		5 / 12 LEU A  25
SER A  26
LEU A 287
GLY A 288
SER A 291
 None
None
HEM  A 501 (-4.3A)
RRM  A 502 (-3.6A)
None
 1.05A 4rrwD-3wvsA:
undetectable		 4rrwD-3wvsA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3wvs PUTATIVE
MONOOXYGENASE
(Streptomyces
sp.
SN-593) 		5 / 12 LEU A  25
SER A  26
LEU A 287
GLY A 288
SER A 291
 None
None
HEM  A 501 (-4.3A)
RRM  A 502 (-3.6A)
None
 1.05A 4rrzD-3wvsA:
undetectable		 4rrzD-3wvsA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3wvs PUTATIVE
MONOOXYGENASE
(Streptomyces
sp.
SN-593) 		5 / 12 LEU A 232
ILE A 197
GLU A 163
ILE A 200
ILE A 213
 None
 1.02A 4y0rA-3wvsA:
undetectable		 4y0rA-3wvsA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 3wvs PUTATIVE
MONOOXYGENASE
(Streptomyces
sp.
SN-593) 		5 / 12 VAL A 194
LEU A 193
ILE A 236
GLY A 237
LEU A 176
 None
None
RRM  A 502 (-4.2A)
RRM  A 502 (-3.7A)
RRM  A 502 (-4.9A)
 1.11A 4y8wB-3wvsA:
32.9		 4y8wB-3wvsA:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3wvs PUTATIVE
MONOOXYGENASE
(Streptomyces
sp.
SN-593) 		4 / 6 ARG A 295
HIS A  98
ARG A 102
ILE A 350
 HEM  A 501 (-2.9A)
HEM  A 501 (-3.9A)
HEM  A 501 (-3.8A)
None
 1.10A 5a06A-3wvsA:
undetectable		 5a06A-3wvsA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 3wvs PUTATIVE
MONOOXYGENASE
(Streptomyces
sp.
SN-593) 		4 / 7 GLU A 279
SER A 276
VAL A 278
ARG A 118
 None
 1.15A 5adlA-3wvsA:
undetectable
5adlB-3wvsA:
undetectable		 5adlA-3wvsA:
22.20
5adlB-3wvsA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 3wvs PUTATIVE
MONOOXYGENASE
(Streptomyces
sp.
SN-593) 		4 / 7 GLU A 279
SER A 276
VAL A 278
ARG A 368
 None
 1.32A 5adlA-3wvsA:
undetectable
5adlB-3wvsA:
undetectable		 5adlA-3wvsA:
22.20
5adlB-3wvsA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 3wvs PUTATIVE
MONOOXYGENASE
(Streptomyces
sp.
SN-593) 		5 / 11 ALA A  52
THR A  53
ALA A 321
VAL A 314
GLY A 304
 None
 0.88A 5lf7K-3wvsA:
undetectable
5lf7L-3wvsA:
undetectable		 5lf7K-3wvsA:
19.60
5lf7L-3wvsA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 3wvs PUTATIVE
MONOOXYGENASE
(Streptomyces
sp.
SN-593) 		5 / 11 ALA A  52
THR A  53
ALA A 321
VAL A 314
GLY A 304
 None
 0.87A 5lf7Y-3wvsA:
undetectable
5lf7Z-3wvsA:
undetectable		 5lf7Y-3wvsA:
19.60
5lf7Z-3wvsA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3wvs PUTATIVE
MONOOXYGENASE
(Streptomyces
sp.
SN-593) 		4 / 6 ILE A 217
ILE A 154
LEU A 238
HIS A 234
 None
None
HEM  A 501 (-4.1A)
None
 0.90A 5vkqA-3wvsA:
undetectable
5vkqB-3wvsA:
undetectable		 5vkqA-3wvsA:
12.85
5vkqB-3wvsA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3wvs PUTATIVE
MONOOXYGENASE
(Streptomyces
sp.
SN-593) 		4 / 6 ILE A 217
ILE A 154
LEU A 238
HIS A 234
 None
None
HEM  A 501 (-4.1A)
None
 0.89A 5vkqA-3wvsA:
undetectable
5vkqD-3wvsA:
undetectable		 5vkqA-3wvsA:
12.85
5vkqD-3wvsA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3wvs PUTATIVE
MONOOXYGENASE
(Streptomyces
sp.
SN-593) 		4 / 7 HIS A 263
ARG A 283
HIS A 343
GLU A 332
 None
 1.38A 6mn4F-3wvsA:
undetectable		 6mn4F-3wvsA:
22.72