SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wwe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Pseudomonas
sp.
VM15C) 		3 / 3 ALA A  50
VAL A  92
TRP A  60
 None
 0.97A 1av2A-3wweA:
undetectable
1av2B-3wweA:
undetectable		 1av2A-3wweA:
4.60
1av2B-3wweA:
4.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Pseudomonas
sp.
VM15C) 		5 / 12 THR A 176
GLU A 126
GLY A 231
TYR A 200
GLY A 127
 AE3  A 900 ( 4.8A)
None
None
None
None
 1.13A 1httB-3wweA:
undetectable		 1httB-3wweA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Pseudomonas
sp.
VM15C) 		5 / 12 THR A 176
GLU A 126
GLY A 231
TYR A 200
GLY A 127
 AE3  A 900 ( 4.8A)
None
None
None
None
 1.12A 1httC-3wweA:
undetectable		 1httC-3wweA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Pseudomonas
sp.
VM15C) 		3 / 3 TRP A  60
VAL A  61
PRO A  62
 None
 0.77A 1rg1A-3wweA:
undetectable		 1rg1A-3wweA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Pseudomonas
sp.
VM15C) 		3 / 3 TRP A  60
VAL A  61
PRO A  62
 None
 0.77A 1rh0A-3wweA:
undetectable		 1rh0A-3wweA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Pseudomonas
sp.
VM15C) 		3 / 3 ALA A  50
VAL A  92
TRP A  60
 None
 0.97A 1w5uA-3wweA:
undetectable
1w5uB-3wweA:
undetectable		 1w5uA-3wweA:
4.60
1w5uB-3wweA:
4.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Pseudomonas
sp.
VM15C) 		3 / 3 TRP A  60
ALA A  50
VAL A  92
 None
 0.98A 1w5uA-3wweA:
undetectable
1w5uB-3wweA:
undetectable		 1w5uA-3wweA:
4.60
1w5uB-3wweA:
4.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Pseudomonas
sp.
VM15C) 		5 / 12 ALA A 181
GLY A 175
GLY A 170
LEU A 168
LEU A 313
 None
 1.00A 1ya4A-3wweA:
16.6		 1ya4A-3wweA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Pseudomonas
sp.
VM15C) 		5 / 12 VAL A  28
VAL A 152
THR A  70
VAL A  61
GLY A  31
 None
 1.14A 2cbrA-3wweA:
undetectable		 2cbrA-3wweA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Pseudomonas
sp.
VM15C) 		5 / 11 GLY A 174
SER A  66
SER A 172
ASN A 120
THR A 176
 None
AE3  A 900 ( 4.0A)
AE3  A 900 (-3.0A)
AE3  A 900 (-3.4A)
AE3  A 900 ( 4.8A)
 1.41A 2hmaA-3wweA:
undetectable		 2hmaA-3wweA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1002_0
(ALDEHYDE
DEHYDROGENASE A)		 3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Pseudomonas
sp.
VM15C) 		3 / 3 GLY A 127
ARG A 180
TYR A 200
 None
 0.70A 2opxA-3wweA:
undetectable		 2opxA-3wweA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Pseudomonas
sp.
VM15C) 		5 / 12 LEU A 313
LEU A 316
TYR A  90
ALA A 190
ASP A 162
 None
 1.03A 3gwuA-3wweA:
undetectable		 3gwuA-3wweA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Pseudomonas
sp.
VM15C) 		5 / 12 LEU A 313
LEU A 316
TYR A  90
ALA A 190
ASP A 162
 None
 1.02A 3gwvA-3wweA:
undetectable		 3gwvA-3wweA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA702_1
(CARBONIC ANHYDRASE 2)		 3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Pseudomonas
sp.
VM15C) 		4 / 7 VAL A 155
LYS A 158
TYR A 159
PRO A  49
 None
 1.25A 3hs4A-3wweA:
undetectable		 3hs4A-3wweA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Pseudomonas
sp.
VM15C) 		5 / 11 PHE A 148
TRP A 189
GLY A 175
GLY A 174
ILE A 171
 None
 1.44A 3owxA-3wweA:
2.9
3owxB-3wweA:
2.8		 3owxA-3wweA:
20.27
3owxB-3wweA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Pseudomonas
sp.
VM15C) 		4 / 8 ASN A 279
PHE A 280
HIS A 289
ALA A 291
 None
 1.01A 4eyzA-3wweA:
undetectable		 4eyzA-3wweA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Pseudomonas
sp.
VM15C) 		4 / 8 ASN A 279
PHE A 280
HIS A 289
ALA A 291
 None
 1.02A 4eyzB-3wweA:
undetectable		 4eyzB-3wweA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Pseudomonas
sp.
VM15C) 		3 / 3 HIS A 298
GLY A 174
ILE A 171
 None
 0.60A 4k50A-3wweA:
undetectable		 4k50A-3wweA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Pseudomonas
sp.
VM15C) 		3 / 3 HIS A 298
GLY A 175
ILE A 171
 None
 0.52A 4k50A-3wweA:
undetectable		 4k50A-3wweA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Pseudomonas
sp.
VM15C) 		3 / 3 HIS A 298
GLY A 174
ILE A 171
 None
 0.61A 4k50I-3wweA:
undetectable		 4k50I-3wweA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Pseudomonas
sp.
VM15C) 		3 / 3 HIS A 298
GLY A 175
ILE A 171
 None
 0.52A 4k50I-3wweA:
undetectable		 4k50I-3wweA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)		 3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Pseudomonas
sp.
VM15C) 		3 / 3 GLY A 231
PRO A 232
GLN A 227
 None
 0.54A 4oltB-3wweA:
undetectable		 4oltB-3wweA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB305_1
(CHITOSANASE)		 3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Pseudomonas
sp.
VM15C) 		3 / 3 GLY A 231
PRO A 232
GLN A 227
 None
 0.58A 4qwpB-3wweA:
undetectable		 4qwpB-3wweA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Pseudomonas
sp.
VM15C) 		5 / 12 LEU A  74
ASN A  82
ALA A  94
VAL A  96
ILE A  46
 None
 1.03A 4x1yD-3wweA:
5.0		 4x1yD-3wweA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Pseudomonas
sp.
VM15C) 		4 / 5 VAL A  28
VAL A  47
GLY A  31
PHE A  45
 None
 1.11A 5d4nA-3wweA:
undetectable
5d4nC-3wweA:
undetectable		 5d4nA-3wweA:
15.66
5d4nC-3wweA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_NPSA602_1
(SERUM ALBUMIN)		 3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Pseudomonas
sp.
VM15C) 		5 / 12 LEU A 254
LEU A 347
ARG A 271
TYR A 348
SER A 196
 None
 1.31A 5dbyA-3wweA:
undetectable		 5dbyA-3wweA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Pseudomonas
sp.
VM15C) 		5 / 12 THR A 176
GLU A 126
GLY A 231
TYR A 200
GLY A 127
 AE3  A 900 ( 4.8A)
None
None
None
None
 1.08A 5e3iA-3wweA:
undetectable		 5e3iA-3wweA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Pseudomonas
sp.
VM15C) 		5 / 11 THR A 176
GLU A 126
GLY A 231
TYR A 200
GLY A 127
 AE3  A 900 ( 4.8A)
None
None
None
None
 1.09A 5e3iB-3wweA:
undetectable		 5e3iB-3wweA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Pseudomonas
sp.
VM15C) 		5 / 12 VAL A 247
GLY A 197
SER A 196
HIS A 226
PRO A 343
 None
 1.04A 5ergB-3wweA:
2.9		 5ergB-3wweA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Pseudomonas
sp.
VM15C) 		4 / 8 HIS A 296
HIS A 298
LEU A 254
SER A 196
 None
 1.03A 5m8rB-3wweA:
undetectable		 5m8rB-3wweA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Pseudomonas
sp.
VM15C) 		4 / 8 HIS A 296
HIS A 298
LEU A 254
SER A 196
 None
 0.99A 5m8rC-3wweA:
undetectable		 5m8rC-3wweA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Pseudomonas
sp.
VM15C) 		3 / 3 THR A  70
THR A  64
ARG A  97
 None
 0.79A 5wm2A-3wweA:
1.9		 5wm2A-3wweA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Pseudomonas
sp.
VM15C) 		4 / 7 LEU A 168
PHE A 167
PHE A 308
LEU A 193
 None
 1.21A 6aycA-3wweA:
undetectable		 6aycA-3wweA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Pseudomonas
sp.
VM15C) 		5 / 10 ILE A  46
GLY A  31
LEU A  74
SER A  83
ASP A  87
 None
 1.39A 6dlzB-3wweA:
3.8
6dlzC-3wweA:
undetectable		 6dlzB-3wweA:
15.89
6dlzC-3wweA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Pseudomonas
sp.
VM15C) 		5 / 10 ILE A  46
GLY A  31
LEU A  74
SER A  83
ASP A  87
 None
 1.40A 6dm1B-3wweA:
4.0
6dm1C-3wweA:
2.5		 6dm1B-3wweA:
15.89
6dm1C-3wweA:
15.89