SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wwh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 3wwh (R)-AMINE
TRANSAMINASE
(Arthrobacter
sp.
KNK168) 		5 / 12 LEU A 213
ALA A 220
ALA A 242
PRO A 244
VAL A 227
 None
 1.26A 1cbrA-3wwhA:
undetectable		 1cbrA-3wwhA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 3wwh (R)-AMINE
TRANSAMINASE
(Arthrobacter
sp.
KNK168) 		5 / 12 LEU A 213
ALA A 220
ALA A 242
PRO A 244
VAL A 227
 None
 1.26A 1cbrB-3wwhA:
undetectable		 1cbrB-3wwhA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3wwh (R)-AMINE
TRANSAMINASE
(Arthrobacter
sp.
KNK168) 		4 / 8 LEU A  80
ALA A  77
VAL A  72
VAL A 123
 None
 0.87A 1epbB-3wwhA:
undetectable		 1epbB-3wwhA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 3wwh (R)-AMINE
TRANSAMINASE
(Arthrobacter
sp.
KNK168) 		5 / 12 LEU A 219
LEU A 252
ILE A 267
ILE A 310
VAL A 293
 None
 0.81A 2ygqA-3wwhA:
undetectable		 2ygqA-3wwhA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3wwh (R)-AMINE
TRANSAMINASE
(Arthrobacter
sp.
KNK168) 		5 / 11 LEU A 213
ALA A 241
ALA A 220
VAL A 171
LEU A 272
 None
 1.30A 3bszE-3wwhA:
undetectable		 3bszE-3wwhA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_D_ACTD229_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3wwh (R)-AMINE
TRANSAMINASE
(Arthrobacter
sp.
KNK168) 		4 / 4 ASP A 232
GLY A 233
LYS A 231
GLU A 277
 None
 1.41A 3hznD-3wwhA:
undetectable		 3hznD-3wwhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 3wwh (R)-AMINE
TRANSAMINASE
(Arthrobacter
sp.
KNK168) 		5 / 12 ILE A  10
GLY A  36
GLY A  37
ALA A 151
TYR A 330
 None
 1.04A 3jayA-3wwhA:
undetectable		 3jayA-3wwhA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 3wwh (R)-AMINE
TRANSAMINASE
(Arthrobacter
sp.
KNK168) 		3 / 3 LEU A  18
TRP A 315
GLY A 286
 None
 0.80A 3l35A-3wwhA:
undetectable
3l35H-3wwhA:
undetectable		 3l35A-3wwhA:
9.06
3l35H-3wwhA:
3.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 3wwh (R)-AMINE
TRANSAMINASE
(Arthrobacter
sp.
KNK168) 		3 / 3 LEU A  18
TRP A 315
GLY A 286
 None
 0.78A 3l35B-3wwhA:
undetectable
3l35K-3wwhA:
undetectable		 3l35B-3wwhA:
9.06
3l35K-3wwhA:
3.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 3wwh (R)-AMINE
TRANSAMINASE
(Arthrobacter
sp.
KNK168) 		4 / 5 ASN A 296
LEU A 273
SER A 292
LEU A 211
 None
 1.01A 4n09C-3wwhA:
undetectable		 4n09C-3wwhA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3wwh (R)-AMINE
TRANSAMINASE
(Arthrobacter
sp.
KNK168) 		5 / 12 TYR A 148
GLY A  59
LEU A  61
ILE A 127
SER A 126
 None
 1.02A 4qtuB-3wwhA:
undetectable		 4qtuB-3wwhA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 3wwh (R)-AMINE
TRANSAMINASE
(Arthrobacter
sp.
KNK168) 		5 / 9 ILE A 157
VAL A 158
GLY A 280
SER A 292
VAL A 167
 None
 1.20A 4r20B-3wwhA:
undetectable		 4r20B-3wwhA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 3wwh (R)-AMINE
TRANSAMINASE
(Arthrobacter
sp.
KNK168) 		5 / 11 ALA A  77
GLY A  75
VAL A 123
LEU A 112
THR A 116
 None
 1.08A 4zmeA-3wwhA:
undetectable		 4zmeA-3wwhA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 3wwh (R)-AMINE
TRANSAMINASE
(Arthrobacter
sp.
KNK168) 		5 / 11 PHE A  70
ALA A  77
GLY A  75
LEU A 112
THR A 116
 None
 1.05A 4zmeA-3wwhA:
undetectable		 4zmeA-3wwhA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 3wwh (R)-AMINE
TRANSAMINASE
(Arthrobacter
sp.
KNK168) 		4 / 4 ASN A 296
LEU A 273
SER A 292
LEU A 211
 None
 0.92A 5kb5A-3wwhA:
undetectable		 5kb5A-3wwhA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3wwh (R)-AMINE
TRANSAMINASE
(Arthrobacter
sp.
KNK168) 		4 / 5 LYS A 106
ALA A 109
LEU A 112
LEU A  80
 None
 0.65A 5vkqA-3wwhA:
undetectable
5vkqD-3wwhA:
undetectable		 5vkqA-3wwhA:
11.58
5vkqD-3wwhA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3wwh (R)-AMINE
TRANSAMINASE
(Arthrobacter
sp.
KNK168) 		4 / 5 LEU A  80
LYS A 106
ALA A 109
LEU A 112
 None
 0.65A 5vkqA-3wwhA:
undetectable
5vkqB-3wwhA:
undetectable		 5vkqA-3wwhA:
11.58
5vkqB-3wwhA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3wwh (R)-AMINE
TRANSAMINASE
(Arthrobacter
sp.
KNK168) 		4 / 5 LEU A  80
LYS A 106
ALA A 109
LEU A 112
 None
 0.66A 5vkqB-3wwhA:
undetectable
5vkqC-3wwhA:
undetectable		 5vkqB-3wwhA:
11.58
5vkqC-3wwhA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3wwh (R)-AMINE
TRANSAMINASE
(Arthrobacter
sp.
KNK168) 		4 / 5 LEU A  80
LYS A 106
ALA A 109
LEU A 112
 None
 0.66A 5vkqC-3wwhA:
undetectable
5vkqD-3wwhA:
undetectable		 5vkqC-3wwhA:
11.58
5vkqD-3wwhA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 3wwh (R)-AMINE
TRANSAMINASE
(Arthrobacter
sp.
KNK168) 		5 / 12 SER A 309
LEU A 258
ILE A 254
VAL A 287
CYH A 281
 None
 1.25A 5vlmB-3wwhA:
undetectable		 5vlmB-3wwhA:
20.74