SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wwn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3wwn PUTATIVE
ACETYLGLUTAMATE
KINASE-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 12 ILE A 210
GLY A 195
VAL A 207
ALA A 251
SER A 191
 None
 1.28A 1nbhA-3wwnA:
undetectable		 1nbhA-3wwnA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3wwn PUTATIVE
ACETYLGLUTAMATE
KINASE-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 12 ILE A 210
GLY A 195
VAL A 207
ALA A 251
SER A 191
 None
 1.27A 1nbhC-3wwnA:
undetectable		 1nbhC-3wwnA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3wwn PUTATIVE
ACETYLGLUTAMATE
KINASE-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 12 ILE A 210
GLY A 195
VAL A 207
ALA A 251
SER A 191
 None
 1.26A 1nbhD-3wwnA:
undetectable		 1nbhD-3wwnA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 3wwn PUTATIVE
ACETYLGLUTAMATE
KINASE-LIKE PROTEIN
(Thermus
thermophilus) 		4 / 7 PRO A 153
LEU A 100
GLY A 102
LEU A 143
 None
 0.76A 1ya4B-3wwnA:
undetectable		 1ya4B-3wwnA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3wwn PUTATIVE
ACETYLGLUTAMATE
KINASE-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 12 ILE A   2
VAL A   3
ALA A 186
LEU A 187
LEU A 181
 None
 0.90A 3mb5A-3wwnA:
4.3		 3mb5A-3wwnA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3wwn PUTATIVE
ACETYLGLUTAMATE
KINASE-LIKE PROTEIN
(Thermus
thermophilus) 		4 / 8 LEU A  31
VAL A  29
LEU A  86
LEU A  90
 None
 1.00A 4l1xA-3wwnA:
undetectable		 4l1xA-3wwnA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)		 3wwn ORFF
(Thermus
thermophilus) 		5 / 12 LEU B  37
GLY B  36
LEU B  42
VAL B   2
MET B   1
 None
 1.41A 4okbA-3wwnB:
undetectable		 4okbA-3wwnB:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 3wwn PUTATIVE
ACETYLGLUTAMATE
KINASE-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 12 ALA A 249
VAL A 253
ALA A  18
LEU A 152
LEU A  33
 None
 1.09A 5xxiA-3wwnA:
undetectable		 5xxiA-3wwnA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_1
(PROTEASE)		 3wwn PUTATIVE
ACETYLGLUTAMATE
KINASE-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A  48
GLY A  37
LEU A  71
PRO A  52
ILE A  73
 None
SO4  A 301 (-3.8A)
None
None
None
 1.12A 6dgxB-3wwnA:
undetectable		 6dgxB-3wwnA:
14.02