SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wwt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DGQ_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 3wwt PROTEIN C'
(Murine
respirovirus) 		4 / 5 ARG B 157
ILE B 104
TYR B 108
THR B 109
 None
 0.99A 3dgqA-3wwtB:
undetectable		 3dgqA-3wwtB:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_1
(NEURAMINIDASE)		 3wwt PROTEIN C'
SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens;
Murine
respirovirus) 		5 / 12 ARG B 154
GLU B 187
ASP A  65
GLU B 184
TYR B 180
 None
 1.38A 4b7qC-3wwtB:
undetectable		 4b7qC-3wwtB:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_A_ZMRA700_1
(NEURAMINIDASE)		 3wwt PROTEIN C'
SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens;
Murine
respirovirus) 		5 / 12 ARG B 154
GLU B 187
ASP A  65
GLU B 184
TYR B 180
 None
 1.42A 4cpnA-3wwtB:
undetectable		 4cpnA-3wwtB:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_B_ZMRB700_1
(NEURAMINIDASE)		 3wwt PROTEIN C'
SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens;
Murine
respirovirus) 		5 / 12 ARG B 154
GLU B 187
ASP A  65
GLU B 184
TYR B 180
 None
 1.37A 4cpnB-3wwtB:
undetectable		 4cpnB-3wwtB:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_1
(NEURAMINIDASE)		 3wwt PROTEIN C'
SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens;
Murine
respirovirus) 		5 / 12 ARG B 154
GLU B 187
ASP A  65
GLU B 184
TYR B 180
 None
 1.41A 4cpzC-3wwtB:
undetectable		 4cpzC-3wwtB:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_1
(NEURAMINIDASE)		 3wwt PROTEIN C'
SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens;
Murine
respirovirus) 		5 / 12 ARG B 154
GLU B 187
ASP A  65
GLU B 184
TYR B 180
 None
 1.48A 4cpzH-3wwtB:
undetectable		 4cpzH-3wwtB:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE401_0
(PROTON-GATED ION
CHANNEL)		 3wwt SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
PROTEIN C'
(Homo
sapiens;
Murine
respirovirus) 		4 / 5 ARG B 157
ILE B 104
GLU B 101
ARG A  88
 None
 1.32A 4zzcA-3wwtB:
undetectable
4zzcE-3wwtB:
undetectable		 4zzcA-3wwtB:
15.09
4zzcE-3wwtB:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 3wwt PROTEIN C'
(Murine
respirovirus) 		5 / 12 ALA B 194
LEU B 197
ALA B 198
PHE B 170
THR B 158
 None
 0.91A 5k9dA-3wwtB:
undetectable		 5k9dA-3wwtB:
13.35