SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wwx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_1
(ESTROGEN RECEPTOR)		 3wwx S12 FAMILY PEPTIDASE
(Streptomyces
sp.
82F2) 		5 / 12 ALA A 297
GLU A 300
LEU A 298
ARG A 132
ILE A 203
 None
 1.06A 1errA-3wwxA:
undetectable		 1errA-3wwxA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_1
(ESTROGEN RECEPTOR)		 3wwx S12 FAMILY PEPTIDASE
(Streptomyces
sp.
82F2) 		5 / 12 ALA A 297
LEU A 298
LEU A 107
ARG A 132
ILE A 203
 None
 1.24A 1errA-3wwxA:
undetectable		 1errA-3wwxA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 3wwx S12 FAMILY PEPTIDASE
(Streptomyces
sp.
82F2) 		3 / 3 ALA A  52
VAL A  55
TRP A 363
 None
 0.82A 1gmkA-3wwxA:
undetectable
1gmkB-3wwxA:
undetectable		 1gmkA-3wwxA:
8.15
1gmkB-3wwxA:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 3wwx S12 FAMILY PEPTIDASE
(Streptomyces
sp.
82F2) 		3 / 3 ALA A  52
VAL A  55
TRP A 363
 None
 0.74A 1gmkC-3wwxA:
undetectable
1gmkD-3wwxA:
undetectable		 1gmkC-3wwxA:
8.15
1gmkD-3wwxA:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 3wwx S12 FAMILY PEPTIDASE
(Streptomyces
sp.
82F2) 		4 / 7 LEU A 115
VAL A 202
MET A 201
LEU A 135
 None
 1.01A 1hk3A-3wwxA:
undetectable		 1hk3A-3wwxA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1864_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3wwx S12 FAMILY PEPTIDASE
(Streptomyces
sp.
82F2) 		3 / 3 TRP A 189
HIS A 334
MET A 321
 None
 1.39A 1l5qB-3wwxA:
undetectable		 1l5qB-3wwxA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 3wwx S12 FAMILY PEPTIDASE
(Streptomyces
sp.
82F2) 		4 / 5 GLU A 102
LEU A  96
LEU A  99
LEU A  97
 None
 1.14A 1np1A-3wwxA:
undetectable		 1np1A-3wwxA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_1
(ESTROGEN RECEPTOR
BETA)		 3wwx S12 FAMILY PEPTIDASE
(Streptomyces
sp.
82F2) 		6 / 12 THR A  90
ALA A  93
LEU A  97
ARG A 132
GLY A 290
LEU A 287
 None
 1.41A 1qknA-3wwxA:
undetectable		 1qknA-3wwxA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TD7_A_NFLA2001_1
(PHOSPHOLIPASE A2
ISOFORM 3)		 3wwx S12 FAMILY PEPTIDASE
(Streptomyces
sp.
82F2) 		5 / 9 LEU A  97
ILE A 219
PHE A  91
GLY A 319
PHE A 283
 None
 1.05A 1td7A-3wwxA:
undetectable		 1td7A-3wwxA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 3wwx S12 FAMILY PEPTIDASE
(Streptomyces
sp.
82F2) 		4 / 6 LEU A 298
LEU A 293
LEU A 318
LEU A 320
 None
 1.02A 2ab2A-3wwxA:
undetectable		 2ab2A-3wwxA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 3wwx S12 FAMILY PEPTIDASE
(Streptomyces
sp.
82F2) 		4 / 5 LEU A 298
LEU A 293
LEU A 318
LEU A 320
 None
 1.04A 2ab2B-3wwxA:
undetectable		 2ab2B-3wwxA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1117_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3wwx S12 FAMILY PEPTIDASE
(Streptomyces
sp.
82F2) 		3 / 3 ASP A  67
ARG A  68
ARG A  63
 None
 1.02A 2j9dA-3wwxA:
undetectable
2j9dC-3wwxA:
undetectable		 2j9dA-3wwxA:
15.69
2j9dC-3wwxA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_1
(ESTROGEN RECEPTOR)		 3wwx S12 FAMILY PEPTIDASE
(Streptomyces
sp.
82F2) 		6 / 12 ALA A 297
GLU A 300
LEU A 298
LEU A 107
ARG A 132
ILE A 203
 None
 1.42A 2jfaA-3wwxA:
undetectable		 2jfaA-3wwxA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3wwx S12 FAMILY PEPTIDASE
(Streptomyces
sp.
82F2) 		4 / 8 TYR A  82
ALA A 345
THR A  43
LEU A  47
 None
 1.01A 2wx2B-3wwxA:
undetectable		 2wx2B-3wwxA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 3wwx S12 FAMILY PEPTIDASE
(Streptomyces
sp.
82F2) 		4 / 8 GLN A 100
LEU A 107
LEU A 293
ARG A 132
 None
 1.15A 2xn3A-3wwxA:
undetectable
2xn3B-3wwxA:
undetectable		 2xn3A-3wwxA:
22.51
2xn3B-3wwxA:
6.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 3wwx S12 FAMILY PEPTIDASE
(Streptomyces
sp.
82F2) 		4 / 4 VAL A  59
ARG A  81
ILE A  87
THR A  70
 None
 1.06A 3cl9A-3wwxA:
undetectable		 3cl9A-3wwxA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 3wwx S12 FAMILY PEPTIDASE
(Streptomyces
sp.
82F2) 		4 / 8 VAL A  59
VAL A  84
ASN A 358
GLY A 357
 None
 0.88A 3hjoB-3wwxA:
undetectable		 3hjoB-3wwxA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 3wwx S12 FAMILY PEPTIDASE
(Streptomyces
sp.
82F2) 		4 / 8 ILE A  87
SER A 342
GLY A 336
SER A 367
 None
DIA  A 401 ( 3.4A)
None
None
 0.93A 3lslA-3wwxA:
undetectable
3lslD-3wwxA:
undetectable		 3lslA-3wwxA:
21.47
3lslD-3wwxA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 3wwx S12 FAMILY PEPTIDASE
(Streptomyces
sp.
82F2) 		4 / 8 SER A 367
ASN A 358
ILE A  87
GLY A 336
 None
 0.82A 3lslA-3wwxA:
undetectable
3lslD-3wwxA:
undetectable		 3lslA-3wwxA:
21.47
3lslD-3wwxA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 3wwx S12 FAMILY PEPTIDASE
(Streptomyces
sp.
82F2) 		4 / 8 SER A 367
ASN A 358
ILE A  87
SER A 342
 None
None
None
DIA  A 401 ( 3.4A)
 0.87A 3lslA-3wwxA:
undetectable
3lslD-3wwxA:
undetectable		 3lslA-3wwxA:
21.47
3lslD-3wwxA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 3wwx S12 FAMILY PEPTIDASE
(Streptomyces
sp.
82F2) 		3 / 3 ASP A 276
ARG A 278
ALA A 227
 None
 0.62A 3mbgC-3wwxA:
undetectable		 3mbgC-3wwxA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 3wwx S12 FAMILY PEPTIDASE
(Streptomyces
sp.
82F2) 		5 / 9 THR A 207
GLU A 204
LEU A  99
LEU A  96
ILE A 105
 None
 1.42A 3nbqA-3wwxA:
undetectable		 3nbqA-3wwxA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 3wwx S12 FAMILY PEPTIDASE
(Streptomyces
sp.
82F2) 		5 / 12 LEU A  97
LEU A 293
LEU A 287
ALA A  93
THR A  90
 None
 0.95A 3r9cA-3wwxA:
undetectable		 3r9cA-3wwxA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3wwx S12 FAMILY PEPTIDASE
(Streptomyces
sp.
82F2) 		4 / 4 LEU A 318
GLY A 319
GLY A 317
THR A 302
 None
 0.89A 3si7A-3wwxA:
undetectable		 3si7A-3wwxA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 3wwx S12 FAMILY PEPTIDASE
(Streptomyces
sp.
82F2) 		3 / 3 HIS A 339
TRP A 167
SER A 246
 DIA  A 401 (-2.7A)
None
DIA  A 401 (-2.8A)
 1.18A 4lrhD-3wwxA:
undetectable		 4lrhD-3wwxA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 3wwx S12 FAMILY PEPTIDASE
(Streptomyces
sp.
82F2) 		5 / 12 VAL A 347
GLY A 333
THR A 302
LEU A 287
THR A  90
 None
 1.29A 4o5fA-3wwxA:
undetectable
4o5fB-3wwxA:
undetectable		 4o5fA-3wwxA:
22.49
4o5fB-3wwxA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 3wwx S12 FAMILY PEPTIDASE
(Streptomyces
sp.
82F2) 		5 / 12 LEU A 287
THR A  90
VAL A 347
GLY A 333
THR A 302
 None
 1.24A 4o5fA-3wwxA:
undetectable
4o5fB-3wwxA:
undetectable		 4o5fA-3wwxA:
22.49
4o5fB-3wwxA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U14_A_0HKA2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3)		 3wwx S12 FAMILY PEPTIDASE
(Streptomyces
sp.
82F2) 		5 / 12 ILE A 274
SER A 275
THR A  70
ALA A  60
ALA A 356
 None
 1.35A 4u14A-3wwxA:
undetectable		 4u14A-3wwxA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)		 3wwx S12 FAMILY PEPTIDASE
(Streptomyces
sp.
82F2) 		6 / 12 THR A  90
ALA A  93
LEU A  97
ARG A 132
GLY A 290
LEU A 287
 None
 1.39A 4xi3B-3wwxA:
undetectable		 4xi3B-3wwxA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_1
(ESTROGEN RECEPTOR)		 3wwx S12 FAMILY PEPTIDASE
(Streptomyces
sp.
82F2) 		6 / 12 THR A  90
ALA A  93
LEU A  97
ARG A 132
GLY A 290
LEU A 287
 None
 1.41A 4xi3C-3wwxA:
undetectable		 4xi3C-3wwxA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 3wwx S12 FAMILY PEPTIDASE
(Streptomyces
sp.
82F2) 		5 / 12 VAL A 347
GLY A 333
THR A 302
LEU A 287
THR A  90
 None
 1.24A 5b8hA-3wwxA:
undetectable
5b8hB-3wwxA:
undetectable		 5b8hA-3wwxA:
23.04
5b8hB-3wwxA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 3wwx S12 FAMILY PEPTIDASE
(Streptomyces
sp.
82F2) 		5 / 12 LEU A 287
THR A  90
VAL A 347
GLY A 333
THR A 302
 None
 1.25A 5b8hA-3wwxA:
undetectable
5b8hB-3wwxA:
undetectable		 5b8hA-3wwxA:
23.04
5b8hB-3wwxA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 3wwx S12 FAMILY PEPTIDASE
(Streptomyces
sp.
82F2) 		5 / 12 ILE A  87
LEU A 280
SER A 367
GLY A 336
TYR A  82
 None
 1.15A 5nnaB-3wwxA:
undetectable		 5nnaB-3wwxA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 3wwx S12 FAMILY PEPTIDASE
(Streptomyces
sp.
82F2) 		5 / 12 ILE A  87
LEU A 280
SER A 367
GLY A 336
TYR A  82
 None
 1.20A 5nnaC-3wwxA:
undetectable		 5nnaC-3wwxA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 3wwx S12 FAMILY PEPTIDASE
(Streptomyces
sp.
82F2) 		5 / 10 LEU A 225
ILE A  87
PHE A  91
LEU A 288
ALA A 286
 None
 1.23A 5y7pB-3wwxA:
undetectable		 5y7pB-3wwxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 3wwx S12 FAMILY PEPTIDASE
(Streptomyces
sp.
82F2) 		5 / 10 LEU A 225
ILE A  87
PHE A  91
LEU A 288
ALA A 286
 None
 1.18A 5y7pD-3wwxA:
undetectable		 5y7pD-3wwxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 3wwx S12 FAMILY PEPTIDASE
(Streptomyces
sp.
82F2) 		5 / 10 LEU A 225
ILE A  87
PHE A  91
LEU A 288
ALA A 286
 None
 1.18A 5y7pH-3wwxA:
undetectable		 5y7pH-3wwxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 3wwx S12 FAMILY PEPTIDASE
(Streptomyces
sp.
82F2) 		4 / 5 PRO A 169
VAL A 197
GLY A 121
VAL A 175
 None
 1.09A 6ak3B-3wwxA:
undetectable		 6ak3B-3wwxA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 3wwx S12 FAMILY PEPTIDASE
(Streptomyces
sp.
82F2) 		4 / 6 GLN A  98
VAL A 206
LEU A 287
MET A 273
 None
 1.27A 6brdB-3wwxA:
0.1		 6brdB-3wwxA:
13.91