SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wwy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3wwy D-LACTATE
DEHYDROGENASE
(Fusobacterium
nucleatum) 		4 / 4 ILE A 218
LEU A 287
VAL A 258
ILE A 255
 None
 0.73A 1fm6D-3wwyA:
undetectable		 1fm6D-3wwyA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3wwy D-LACTATE
DEHYDROGENASE
(Fusobacterium
nucleatum) 		5 / 10 VAL A 233
LEU A 232
LEU A 197
GLY A 150
LEU A 161
 None
 0.88A 1pxxA-3wwyA:
undetectable		 1pxxA-3wwyA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3wwy D-LACTATE
DEHYDROGENASE
(Fusobacterium
nucleatum) 		5 / 12 VAL A 233
LEU A 232
LEU A 197
GLY A 150
LEU A 161
 None
 0.89A 1pxxC-3wwyA:
undetectable		 1pxxC-3wwyA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 3wwy D-LACTATE
DEHYDROGENASE
(Fusobacterium
nucleatum) 		5 / 12 LEU A 114
LEU A 206
SER A 222
VAL A 258
LEU A 287
 None
 1.07A 1s19A-3wwyA:
undetectable		 1s19A-3wwyA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)		 3wwy D-LACTATE
DEHYDROGENASE
(Fusobacterium
nucleatum) 		3 / 3 THR A 154
PRO A 179
TYR A 191
 None
 0.96A 2dxrA-3wwyA:
1.7		 2dxrA-3wwyA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 3wwy D-LACTATE
DEHYDROGENASE
(Fusobacterium
nucleatum) 		5 / 11 LEU A 206
ILE A 152
GLY A 153
GLY A 158
LEU A 232
 None
 0.95A 2qmmA-3wwyA:
2.3
2qmmB-3wwyA:
2.5		 2qmmA-3wwyA:
21.94
2qmmB-3wwyA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 3wwy D-LACTATE
DEHYDROGENASE
(Fusobacterium
nucleatum) 		5 / 11 ILE A 255
LYS A 121
ASN A 123
LEU A 232
ILE A 231
 None
GOL  A 405 (-3.1A)
None
None
None
 1.31A 3a50B-3wwyA:
undetectable		 3a50B-3wwyA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 3wwy D-LACTATE
DEHYDROGENASE
(Fusobacterium
nucleatum) 		5 / 11 ILE A 255
LYS A 121
ASN A 123
LEU A 232
ILE A 231
 None
GOL  A 405 (-3.1A)
None
None
None
 1.28A 3a50C-3wwyA:
undetectable		 3a50C-3wwyA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 3wwy D-LACTATE
DEHYDROGENASE
(Fusobacterium
nucleatum) 		4 / 7 VAL A 112
ILE A 231
GLY A 256
LEU A 250
 None
None
GOL  A 405 ( 3.8A)
None
 0.76A 3bjwB-3wwyA:
undetectable		 3bjwB-3wwyA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_3
(PHOSPHOLIPASE A2)		 3wwy D-LACTATE
DEHYDROGENASE
(Fusobacterium
nucleatum) 		4 / 7 VAL A 112
ILE A 231
GLY A 256
LEU A 250
 None
None
GOL  A 405 ( 3.8A)
None
 0.85A 3bjwF-3wwyA:
undetectable		 3bjwF-3wwyA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 3wwy D-LACTATE
DEHYDROGENASE
(Fusobacterium
nucleatum) 		4 / 7 VAL A 112
ILE A 231
GLY A 256
LEU A 250
 None
None
GOL  A 405 ( 3.8A)
None
 0.78A 3bjwH-3wwyA:
undetectable		 3bjwH-3wwyA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 3wwy D-LACTATE
DEHYDROGENASE
(Fusobacterium
nucleatum) 		5 / 10 PHE A 189
VAL A 183
ILE A 152
ASN A 207
GLY A 158
 None
 1.22A 3km6A-3wwyA:
undetectable		 3km6A-3wwyA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 3wwy D-LACTATE
DEHYDROGENASE
(Fusobacterium
nucleatum) 		4 / 6 LEU A 206
LEU A 232
ILE A 255
MET A 223
 None
 0.98A 4do3B-3wwyA:
undetectable		 4do3B-3wwyA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 3wwy D-LACTATE
DEHYDROGENASE
(Fusobacterium
nucleatum) 		5 / 12 LEU A 206
ASN A 207
GLY A 236
LEU A 260
ILE A 151
 None
 0.78A 4p6xA-3wwyA:
undetectable		 4p6xA-3wwyA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 3wwy D-LACTATE
DEHYDROGENASE
(Fusobacterium
nucleatum) 		5 / 12 LEU A 206
ASN A 207
GLY A 236
LEU A 260
ILE A 151
 None
 0.77A 4p6xE-3wwyA:
undetectable		 4p6xE-3wwyA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 3wwy D-LACTATE
DEHYDROGENASE
(Fusobacterium
nucleatum) 		5 / 12 LEU A 206
ASN A 207
GLY A 236
LEU A 260
ILE A 151
 None
 0.77A 4p6xI-3wwyA:
undetectable		 4p6xI-3wwyA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 3wwy D-LACTATE
DEHYDROGENASE
(Fusobacterium
nucleatum) 		5 / 11 LEU A 144
ARG A 120
GLY A 256
ILE A 203
VAL A 233
 None
None
GOL  A 405 ( 3.8A)
None
None
 1.13A 5hjiA-3wwyA:
6.6		 5hjiA-3wwyA:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3wwy D-LACTATE
DEHYDROGENASE
(Fusobacterium
nucleatum) 		5 / 12 VAL A 233
LEU A 232
LEU A 197
GLY A 150
LEU A 161
 None
 0.99A 5ikqA-3wwyA:
undetectable		 5ikqA-3wwyA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3wwy D-LACTATE
DEHYDROGENASE
(Fusobacterium
nucleatum) 		5 / 12 VAL A 233
LEU A 232
LEU A 197
GLY A 150
LEU A 161
 None
 0.99A 5ikqB-3wwyA:
undetectable		 5ikqB-3wwyA:
21.22