SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wwz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 3wwz D-LACTATE
DEHYDROGENASE
(FERMENTATIVE)
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 256
THR A 293
ILE A 200
HIS A 108
ILE A 113
 None
 0.85A 1bx4A-3wwzA:
3.0		 1bx4A-3wwzA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 3wwz D-LACTATE
DEHYDROGENASE
(FERMENTATIVE)
(Pseudomonas
aeruginosa) 		4 / 4 ILE A 200
MET A 223
VAL A 238
GLY A 148
 None
 1.41A 1e06B-3wwzA:
undetectable		 1e06B-3wwzA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3wwz D-LACTATE
DEHYDROGENASE
(FERMENTATIVE)
(Pseudomonas
aeruginosa) 		3 / 3 VAL A 259
ASP A 258
GLU A 263
 None
 0.76A 2qeuA-3wwzA:
undetectable		 2qeuA-3wwzA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 3wwz D-LACTATE
DEHYDROGENASE
(FERMENTATIVE)
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 200
LEU A 142
ILE A 230
MET A 163
VAL A 105
 None
 1.17A 2ygpA-3wwzA:
undetectable		 2ygpA-3wwzA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3wwz D-LACTATE
DEHYDROGENASE
(FERMENTATIVE)
(Pseudomonas
aeruginosa) 		6 / 12 HIS A 121
LEU A 229
GLY A 256
ASP A 258
LEU A 255
LEU A 243
 None
 1.44A 3cjtO-3wwzA:
7.5		 3cjtO-3wwzA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3wwz D-LACTATE
DEHYDROGENASE
(FERMENTATIVE)
(Pseudomonas
aeruginosa) 		3 / 3 ILE A   3
PHE A  29
HIS A  23
 None
 0.76A 3h0aA-3wwzA:
undetectable		 3h0aA-3wwzA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 3wwz D-LACTATE
DEHYDROGENASE
(FERMENTATIVE)
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 111
PHE A 159
GLU A 107
LEU A 112
ILE A 230
 None
 1.33A 3kvrA-3wwzA:
2.9		 3kvrA-3wwzA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3wwz D-LACTATE
DEHYDROGENASE
(FERMENTATIVE)
(Pseudomonas
aeruginosa) 		5 / 10 MET A 163
PHE A 159
ALA A 172
GLY A 156
ALA A 242
 None
 1.24A 4fe1A-3wwzA:
undetectable
4fe1J-3wwzA:
undetectable		 4fe1A-3wwzA:
18.23
4fe1J-3wwzA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3wwz D-LACTATE
DEHYDROGENASE
(FERMENTATIVE)
(Pseudomonas
aeruginosa) 		5 / 10 MET A 163
PHE A 159
ALA A 172
GLY A 156
ALA A 246
 None
 1.42A 4fe1A-3wwzA:
undetectable
4fe1J-3wwzA:
undetectable		 4fe1A-3wwzA:
18.23
4fe1J-3wwzA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3wwz D-LACTATE
DEHYDROGENASE
(FERMENTATIVE)
(Pseudomonas
aeruginosa) 		5 / 11 SER A  15
THR A 310
THR A 311
SER A 101
THR A 300
 None
 1.46A 4qvyV-3wwzA:
undetectable
4qvyb-3wwzA:
undetectable		 4qvyV-3wwzA:
22.79
4qvyb-3wwzA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3wwz D-LACTATE
DEHYDROGENASE
(FERMENTATIVE)
(Pseudomonas
aeruginosa) 		5 / 11 SER A  15
THR A 310
THR A 311
SER A 101
THR A 300
 None
 1.46A 4qvyH-3wwzA:
undetectable
4qvyN-3wwzA:
undetectable		 4qvyH-3wwzA:
22.79
4qvyN-3wwzA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3wwz D-LACTATE
DEHYDROGENASE
(FERMENTATIVE)
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 116
PHE A 140
ILE A 113
 None
 0.60A 5dzk1-3wwzA:
undetectable
5dzkF-3wwzA:
undetectable
5dzkM-3wwzA:
undetectable		 5dzk1-3wwzA:
1.07
5dzkF-3wwzA:
22.25
5dzkM-3wwzA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3wwz D-LACTATE
DEHYDROGENASE
(FERMENTATIVE)
(Pseudomonas
aeruginosa) 		5 / 11 SER A  15
THR A 310
THR A 311
SER A 101
THR A 300
 None
 1.46A 5l5fV-3wwzA:
undetectable
5l5fb-3wwzA:
undetectable		 5l5fV-3wwzA:
22.79
5l5fb-3wwzA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3wwz D-LACTATE
DEHYDROGENASE
(FERMENTATIVE)
(Pseudomonas
aeruginosa) 		5 / 11 SER A  15
THR A 310
THR A 311
SER A 101
THR A 300
 None
 1.45A 5l5fH-3wwzA:
undetectable
5l5fN-3wwzA:
undetectable		 5l5fH-3wwzA:
22.79
5l5fN-3wwzA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 3wwz D-LACTATE
DEHYDROGENASE
(FERMENTATIVE)
(Pseudomonas
aeruginosa) 		3 / 3 HIS A  23
ASN A  20
ALA A  18
 None
 0.81A 5n4tB-3wwzA:
undetectable		 5n4tB-3wwzA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3wwz D-LACTATE
DEHYDROGENASE
(FERMENTATIVE)
(Pseudomonas
aeruginosa) 		4 / 6 LEU A  92
VAL A  72
LEU A  56
VAL A  48
 None
 0.94A 5x7zA-3wwzA:
undetectable		 5x7zA-3wwzA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3wwz D-LACTATE
DEHYDROGENASE
(FERMENTATIVE)
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 142
ILE A 113
GLY A 111
ILE A 162
MET A 163
 None
 1.01A 5ycnA-3wwzA:
undetectable		 5ycnA-3wwzA:
21.94