SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wx5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 3wx5 CELLULASE
(uncultured
bacterium) 		4 / 8 ALA A 184
LEU A 181
LEU A 258
LEU A 121
 None
 0.73A 1dvtA-3wx5A:
undetectable
1dvtB-3wx5A:
undetectable		 1dvtA-3wx5A:
18.80
1dvtB-3wx5A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 3wx5 CELLULASE
(uncultured
bacterium) 		4 / 8 PHE A 254
TYR A  53
LEU A 121
LEU A 214
 None
 1.00A 2bfpA-3wx5A:
undetectable		 2bfpA-3wx5A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3wx5 CELLULASE
(uncultured
bacterium) 		4 / 6 ARG A 247
ASN A  57
PRO A  94
ALA A  92
 None
 1.38A 2ejfB-3wx5A:
undetectable		 2ejfB-3wx5A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 3wx5 CELLULASE
(uncultured
bacterium) 		4 / 5 GLY A 167
ARG A 134
GLY A 133
GLU A 244
 None
 1.15A 4z2eB-3wx5A:
undetectable
4z2eC-3wx5A:
undetectable		 4z2eB-3wx5A:
17.36
4z2eC-3wx5A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 3wx5 CELLULASE
(uncultured
bacterium) 		4 / 6 SER A 251
GLY A  51
ASP A  47
ARG A  54
 None
 0.91A 5cdpA-3wx5A:
undetectable
5cdpB-3wx5A:
undetectable		 5cdpA-3wx5A:
17.86
5cdpB-3wx5A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 3wx5 CELLULASE
(uncultured
bacterium) 		4 / 6 ARG A 201
ALA A 199
PRO A 171
GLU A 241
 None
 1.42A 5odqA-3wx5A:
undetectable		 5odqA-3wx5A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3wx5 CELLULASE
(uncultured
bacterium) 		4 / 5 GLY A 103
THR A 150
HIS A 234
SER A 146
 None
 1.07A 6jmjA-3wx5A:
undetectable		 6jmjA-3wx5A:
22.76