SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wxb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_A_STRA1_1
(PROGESTERONE
RECEPTOR)		 3wxb UNCHARACTERIZED
PROTEIN
(Gallus
gallus) 		5 / 12 LEU A 185
ASN A 186
LEU A 188
GLN A 192
PHE A 249
 None
 0.94A 1a28A-3wxbA:
undetectable		 1a28A-3wxbA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)		 3wxb UNCHARACTERIZED
PROTEIN
(Gallus
gallus) 		5 / 12 LEU A 185
ASN A 186
LEU A 188
GLN A 192
PHE A 249
 None
 1.02A 1gs4A-3wxbA:
undetectable		 1gs4A-3wxbA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 3wxb UNCHARACTERIZED
PROTEIN
(Gallus
gallus) 		5 / 12 LEU A 185
ASN A 186
LEU A 188
GLN A 192
THR A 160
 None
 1.12A 1p93A-3wxbA:
undetectable		 1p93A-3wxbA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_B_T98B202_1
(PROGESTERONE
RECEPTOR)		 3wxb UNCHARACTERIZED
PROTEIN
(Gallus
gallus) 		5 / 12 LEU A 185
ASN A 186
LEU A 188
GLN A 192
PHE A 249
 None
 0.92A 1zucB-3wxbA:
undetectable		 1zucB-3wxbA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 3wxb UNCHARACTERIZED
PROTEIN
(Gallus
gallus) 		5 / 12 LEU A 185
ASN A 186
LEU A 188
GLN A 192
PHE A 249
 None
 0.84A 2oz7A-3wxbA:
undetectable		 2oz7A-3wxbA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3wxb UNCHARACTERIZED
PROTEIN
(Gallus
gallus) 		4 / 8 ILE A 157
ASN A 120
SER A 181
SER A 159
 NDP  A 300 (-4.4A)
None
None
EDO  A 301 ( 2.5A)
 1.14A 2zw9B-3wxbA:
6.5		 2zw9B-3wxbA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 3wxb UNCHARACTERIZED
PROTEIN
(Gallus
gallus) 		4 / 5 LEU A  54
GLN A  49
LEU A  51
GLU A  50
 None
 1.15A 3h5gA-3wxbA:
undetectable
3h5gB-3wxbA:
undetectable		 3h5gA-3wxbA:
9.95
3h5gB-3wxbA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 3wxb UNCHARACTERIZED
PROTEIN
(Gallus
gallus) 		4 / 7 LEU A  10
LEU A  66
ASN A  95
THR A  69
 None
None
None
NDP  A 300 ( 4.0A)
 0.93A 3lm8A-3wxbA:
undetectable
3lm8C-3wxbA:
2.1		 3lm8A-3wxbA:
21.00
3lm8C-3wxbA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 3wxb UNCHARACTERIZED
PROTEIN
(Gallus
gallus) 		4 / 5 SER A 159
ILE A  18
TYR A 178
GLY A 209
 EDO  A 301 ( 2.5A)
NDP  A 300 (-4.0A)
EDO  A 301 ( 4.3A)
None
 0.89A 3uboB-3wxbA:
5.6		 3uboB-3wxbA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 3wxb UNCHARACTERIZED
PROTEIN
(Gallus
gallus) 		5 / 12 LEU A  93
GLY A  13
ALA A  14
LEU A 127
GLY A  21
 None
NDP  A 300 (-3.2A)
None
None
None
 1.13A 3vaqB-3wxbA:
6.7		 3vaqB-3wxbA:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 3wxb UNCHARACTERIZED
PROTEIN
(Gallus
gallus) 		5 / 12 LEU A  26
GLY A  19
GLY A  21
VAL A 231
ALA A  38
 None
 1.00A 4a6dA-3wxbA:
3.4		 4a6dA-3wxbA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CUT_A_TYLA2971_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 3wxb UNCHARACTERIZED
PROTEIN
(Gallus
gallus) 		4 / 4 VAL A 211
VAL A 227
ASN A  96
ILE A 157
 NDP  A 300 (-4.0A)
None
NDP  A 300 (-3.3A)
NDP  A 300 (-4.4A)
 1.24A 4cutA-3wxbA:
undetectable		 4cutA-3wxbA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3wxb UNCHARACTERIZED
PROTEIN
(Gallus
gallus) 		4 / 8 HIS A 207
PRO A 208
ALA A 161
TYR A 178
 NDP  A 300 ( 4.7A)
NDP  A 300 (-4.2A)
EDO  A 301 ( 3.8A)
EDO  A 301 ( 4.3A)
 0.91A 4k0bB-3wxbA:
undetectable		 4k0bB-3wxbA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3wxb UNCHARACTERIZED
PROTEIN
(Gallus
gallus) 		4 / 8 HIS A 207
PRO A 208
ALA A 161
TYR A 178
 NDP  A 300 ( 4.7A)
NDP  A 300 (-4.2A)
EDO  A 301 ( 3.8A)
EDO  A 301 ( 4.3A)
 0.95A 4l7iB-3wxbA:
undetectable		 4l7iB-3wxbA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 3wxb UNCHARACTERIZED
PROTEIN
(Gallus
gallus) 		3 / 3 PRO A  32
ASN A  60
HIS A  58
 None
 0.91A 4ma3H-3wxbA:
undetectable
4ma3L-3wxbA:
undetectable		 4ma3H-3wxbA:
23.49
4ma3L-3wxbA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 3wxb UNCHARACTERIZED
PROTEIN
(Gallus
gallus) 		3 / 3 GLU A 253
THR A 160
HIS A 207
 None
None
NDP  A 300 ( 4.7A)
 0.87A 4q15B-3wxbA:
undetectable		 4q15B-3wxbA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 3wxb UNCHARACTERIZED
PROTEIN
(Gallus
gallus) 		5 / 11 MET A 234
LEU A 238
LEU A 241
LEU A 188
ILE A 157
 None
None
None
None
NDP  A 300 (-4.4A)
 1.05A 4zowA-3wxbA:
undetectable		 4zowA-3wxbA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 3wxb UNCHARACTERIZED
PROTEIN
(Gallus
gallus) 		5 / 10 PRO A  43
LEU A  66
ILE A  74
ALA A 130
VAL A  81
 None
 1.29A 5m0oA-3wxbA:
undetectable		 5m0oA-3wxbA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 3wxb UNCHARACTERIZED
PROTEIN
(Gallus
gallus) 		5 / 12 GLY A 233
GLN A  24
LEU A  26
LEU A  27
LEU A  29
 None
 1.15A 5nwwA-3wxbA:
undetectable		 5nwwA-3wxbA:
12.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WQP_A_NCAA302_0
(PROBABLE
DEHYDROGENASE)		 3wxb UNCHARACTERIZED
PROTEIN
(Gallus
gallus) 		5 / 8 SER A 159
TYR A 178
HIS A 207
TRP A 210
MET A 215
 EDO  A 301 ( 2.5A)
EDO  A 301 ( 4.3A)
NDP  A 300 ( 4.7A)
None
NDP  A 300 (-3.5A)
 0.52A 5wqpA-3wxbA:
28.2		 5wqpA-3wxbA:
30.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6L_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3wxb UNCHARACTERIZED
PROTEIN
(Gallus
gallus) 		5 / 9 ILE A  74
ALA A  78
MET A 134
LEU A  10
ILE A 154
 None
 1.30A 5z6lA-3wxbA:
undetectable		 5z6lA-3wxbA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 3wxb UNCHARACTERIZED
PROTEIN
(Gallus
gallus) 		5 / 7 ASN A  95
GLY A 247
ALA A 248
VAL A 237
LEU A 206
 None
 1.27A 6dwnB-3wxbA:
undetectable		 6dwnB-3wxbA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 3wxb UNCHARACTERIZED
PROTEIN
(Gallus
gallus) 		5 / 12 ASP A 245
LEU A  26
LEU A  29
ALA A 153
LEU A 206
 None
 1.09A 6ew0B-3wxbA:
6.7		 6ew0B-3wxbA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 3wxb UNCHARACTERIZED
PROTEIN
(Gallus
gallus) 		5 / 12 ASP A 245
LEU A  26
LEU A  29
ALA A 153
LEU A 206
 None
 1.09A 6ew0D-3wxbA:
6.2		 6ew0D-3wxbA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 3wxb UNCHARACTERIZED
PROTEIN
(Gallus
gallus) 		5 / 12 ASP A 245
LEU A  26
LEU A  29
ALA A 153
LEU A 206
 None
 1.09A 6ew0H-3wxbA:
6.4		 6ew0H-3wxbA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 3wxb UNCHARACTERIZED
PROTEIN
(Gallus
gallus) 		5 / 12 ASP A 245
LEU A  26
LEU A  29
ALA A 153
LEU A 206
 None
 1.09A 6ew0I-3wxbA:
6.4		 6ew0I-3wxbA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_B_PQNB2002_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3wxb UNCHARACTERIZED
PROTEIN
(Gallus
gallus) 		5 / 9 SER A   8
ILE A 155
ALA A 153
LEU A 135
ALA A 138
 None
 1.49A 6hqbB-3wxbA:
undetectable		 6hqbB-3wxbA:
14.86