SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wxm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_1
(HIV-1 PROTEASE)		 3wxm PROTEIN PELOTA
HOMOLOG
(Aeropyrum
pernix) 		5 / 10 ALA B 129
VAL B 195
ILE B 244
VAL B 232
ILE B 131
 None
 0.97A 1hsgA-3wxmB:
undetectable		 1hsgA-3wxmB:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 3wxm PROTEIN PELOTA
HOMOLOG
(Aeropyrum
pernix) 		4 / 8 LEU B 291
PRO B 326
SER B 249
GLU B 254
 None
 0.81A 1jtvA-3wxmB:
undetectable		 1jtvA-3wxmB:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 3wxm PROTEIN PELOTA
HOMOLOG
(Aeropyrum
pernix) 		5 / 10 ALA B 220
THR B 221
VAL B 222
THR B 224
ALA B 132
 None
 1.15A 1r55A-3wxmB:
undetectable		 1r55A-3wxmB:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_2
(PHOSPHOLIPASE A2
HOMOLOG 2)		 3wxm PROTEIN PELOTA
HOMOLOG
(Aeropyrum
pernix) 		5 / 11 LEU B 141
LEU B 152
VAL B 183
ARG B 190
HIS B 189
 None
 1.03A 1y4lB-3wxmB:
undetectable		 1y4lB-3wxmB:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 3wxm PROTEIN PELOTA
HOMOLOG
(Aeropyrum
pernix) 		4 / 5 VAL B 175
TYR B 174
VAL B 134
ASP B 135
 None
 1.22A 2x45C-3wxmB:
undetectable		 2x45C-3wxmB:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 3wxm PROTEIN PELOTA
HOMOLOG
(Aeropyrum
pernix) 		3 / 3 ARG B 233
GLY B 231
SER B 240
 None
 0.63A 2xctB-3wxmB:
undetectable		 2xctB-3wxmB:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3wxm PROTEIN PELOTA
HOMOLOG
(Aeropyrum
pernix) 		5 / 12 GLY B 227
GLY B 198
ILE B 151
GLY B 231
GLY B 228
 None
 1.09A 3axzA-3wxmB:
undetectable		 3axzA-3wxmB:
26.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 3wxm PROTEIN PELOTA
HOMOLOG
(Aeropyrum
pernix) 		4 / 6 THR B  96
ILE B  60
LEU B  58
THR B  40
 None
 0.56A 3deuB-3wxmB:
undetectable		 3deuB-3wxmB:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_2
(PROTEASE)		 3wxm PROTEIN PELOTA
HOMOLOG
(Aeropyrum
pernix) 		5 / 11 GLY B 198
ALA B 197
ILE B 131
VAL B 241
ILE B 182
 None
 1.14A 3ebzB-3wxmB:
undetectable		 3ebzB-3wxmB:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_1
(HIV-1 PROTEASE)		 3wxm PROTEIN PELOTA
HOMOLOG
(Aeropyrum
pernix) 		5 / 12 ALA B 129
VAL B 195
ILE B 244
ILE B 250
VAL B 232
 None
 1.06A 3k4vC-3wxmB:
undetectable		 3k4vC-3wxmB:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 3wxm PROTEIN PELOTA
HOMOLOG
(Aeropyrum
pernix) 		4 / 8 ILE B  79
SER B  95
SER B  64
GLY B  78
 None
 0.92A 3lslA-3wxmB:
undetectable
3lslD-3wxmB:
undetectable		 3lslA-3wxmB:
22.25
3lslD-3wxmB:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 3wxm PROTEIN PELOTA
HOMOLOG
(Aeropyrum
pernix) 		4 / 8 ILE B  79
SER B  95
SER B  64
GLY B  78
 None
 0.89A 3lslA-3wxmB:
undetectable
3lslD-3wxmB:
undetectable		 3lslA-3wxmB:
22.25
3lslD-3wxmB:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 3wxm PROTEIN PELOTA
HOMOLOG
(Aeropyrum
pernix) 		5 / 9 LEU B 104
VAL B  36
LEU B  74
THR B  96
ILE B  76
 None
 1.14A 3tbgD-3wxmB:
undetectable		 3tbgD-3wxmB:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_2
(PROTEASE)		 3wxm PROTEIN PELOTA
HOMOLOG
(Aeropyrum
pernix) 		5 / 12 ALA B 129
VAL B 195
ILE B 244
VAL B 232
ILE B 131
 None
 0.93A 3tkgD-3wxmB:
undetectable		 3tkgD-3wxmB:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3wxm PROTEIN PELOTA
HOMOLOG
(Aeropyrum
pernix) 		4 / 8 LEU B 120
ARG B 108
VAL B  13
VAL B 106
 None
 0.94A 4em2A-3wxmB:
undetectable		 4em2A-3wxmB:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 3wxm PROTEIN PELOTA
HOMOLOG
(Aeropyrum
pernix) 		4 / 7 ARG B  61
VAL B  35
GLU B 107
ARG B  59
 None
 1.22A 4mv7A-3wxmB:
2.9		 4mv7A-3wxmB:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 3wxm PROTEIN PELOTA
HOMOLOG
(Aeropyrum
pernix) 		3 / 3 SER B  95
ALA B  97
VAL B  98
 None
 0.55A 4o2bA-3wxmB:
undetectable		 4o2bA-3wxmB:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 3wxm PROTEIN PELOTA
HOMOLOG
(Aeropyrum
pernix) 		5 / 9 PRO B 330
VAL B 232
ALA B 145
THR B 128
ALA B 142
 None
 1.17A 4oqrA-3wxmB:
undetectable		 4oqrA-3wxmB:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_2
(PROTEASE)		 3wxm PROTEIN PELOTA
HOMOLOG
(Aeropyrum
pernix) 		5 / 11 ALA B 129
VAL B 195
ILE B 244
VAL B 232
ILE B 131
 None
 0.96A 4qgiB-3wxmB:
undetectable		 4qgiB-3wxmB:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 3wxm PROTEIN PELOTA
HOMOLOG
(Aeropyrum
pernix) 		4 / 5 ILE B 250
PRO B 326
HIS B 298
VAL B 322
 None
 1.33A 4s0vA-3wxmB:
undetectable		 4s0vA-3wxmB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 3wxm PROTEIN PELOTA
HOMOLOG
(Aeropyrum
pernix) 		4 / 4 LEU B 248
MET B 149
ILE B 244
LEU B 236
 None
 1.37A 5nfpA-3wxmB:
undetectable		 5nfpA-3wxmB:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)		 3wxm PROTEIN PELOTA
HOMOLOG
(Aeropyrum
pernix) 		4 / 8 LEU B 120
GLU B 114
THR B  29
TRP B 112
 None
 1.25A 6c71B-3wxmB:
undetectable		 6c71B-3wxmB:
11.44