SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wxo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		4 / 8 HIS A 263
GLY A 266
LYS A 267
ASP A 375
 HEM  A 801 (-3.3A)
HEM  A 801 (-3.1A)
None
None
 0.57A 1aegA-3wxoA:
31.5		 1aegA-3wxoA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		4 / 6 LEU A 527
LEU A 546
LEU A 615
LEU A 612
 None
 0.88A 1errA-3wxoA:
undetectable		 1errA-3wxoA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		5 / 11 ALA A 109
ALA A 149
MET A 414
GLN A  52
HIS A 411
 None
 1.35A 1iiuA-3wxoA:
undetectable		 1iiuA-3wxoA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_2
(POL POLYPROTEIN)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		5 / 12 GLY A 616
VAL A 533
GLY A 610
ILE A 609
VAL A 463
 None
 0.99A 1k6cB-3wxoA:
undetectable		 1k6cB-3wxoA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		5 / 12 GLY A 610
GLY A 611
VAL A 533
LEU A 634
LEU A 615
 None
 0.80A 1mx1D-3wxoA:
undetectable		 1mx1D-3wxoA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		5 / 12 GLY A 610
GLY A 611
VAL A 533
LEU A 634
LEU A 615
 None
 1.05A 1mx1F-3wxoA:
undetectable		 1mx1F-3wxoA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		4 / 7 LEU A  35
LEU A 591
LEU A 598
GLY A 599
 None
 0.89A 1n13D-3wxoA:
undetectable
1n13E-3wxoA:
undetectable		 1n13D-3wxoA:
8.69
1n13E-3wxoA:
5.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		3 / 3 ARG A 106
ASP A 573
ASN A 577
 None
 0.93A 1nbhA-3wxoA:
undetectable		 1nbhA-3wxoA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		3 / 3 ARG A 106
ASP A 573
ASN A 577
 None
 0.92A 1nbhD-3wxoA:
undetectable		 1nbhD-3wxoA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_1
(BILE ACID RECEPTOR)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		5 / 12 LEU A 151
MET A  89
ILE A 158
ILE A 138
TRP A 148
 None
 1.47A 1osvB-3wxoA:
undetectable		 1osvB-3wxoA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		3 / 3 ARG A 576
ARG A 471
ILE A 525
 None
 0.70A 1uobA-3wxoA:
undetectable		 1uobA-3wxoA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		5 / 12 LEU A 510
LEU A 457
GLY A 529
ALA A 466
ALA A 470
 None
 0.99A 2bm9C-3wxoA:
undetectable		 2bm9C-3wxoA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		5 / 12 LEU A 510
LEU A 457
GLY A 529
ALA A 466
ALA A 470
 None
 1.06A 2bm9D-3wxoA:
undetectable		 2bm9D-3wxoA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		5 / 12 LEU A 510
LEU A 457
GLY A 529
ALA A 466
ALA A 470
 None
 1.06A 2br4A-3wxoA:
undetectable		 2br4A-3wxoA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		5 / 12 LEU A 510
LEU A 457
GLY A 529
ALA A 466
ALA A 470
 None
 1.04A 2br4C-3wxoA:
undetectable		 2br4C-3wxoA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		5 / 12 LEU A 510
LEU A 457
GLY A 529
ALA A 466
ALA A 470
 None
 1.06A 2br4D-3wxoA:
undetectable		 2br4D-3wxoA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		5 / 12 LEU A 510
LEU A 457
GLY A 529
ALA A 466
ALA A 470
 None
 1.06A 2br4E-3wxoA:
undetectable		 2br4E-3wxoA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		3 / 3 ARG A 101
GLY A 187
PRO A 188
 None
 0.40A 2hreD-3wxoA:
undetectable		 2hreD-3wxoA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_1
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		3 / 3 GLN A 114
THR A 307
TRP A  78
 None
HEM  A 801 ( 3.3A)
None
 1.14A 2rctA-3wxoA:
undetectable		 2rctA-3wxoA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		4 / 9 ILE A 452
ARG A 451
ALA A 519
VAL A 524
 None
 1.05A 2vufB-3wxoA:
undetectable		 2vufB-3wxoA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		5 / 10 ILE A 436
GLY A 484
GLY A 481
PHE A 565
PRO A 416
 None
 1.11A 2y7pA-3wxoA:
undetectable		 2y7pA-3wxoA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		5 / 11 ARG A 486
ILE A 436
PRO A 437
GLY A 553
SER A 520
 None
 1.46A 3bpxA-3wxoA:
1.4
3bpxB-3wxoA:
1.9		 3bpxA-3wxoA:
12.73
3bpxB-3wxoA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		3 / 3 GLY A 112
ASP A 176
SER A 147
 None
 0.66A 3brfA-3wxoA:
undetectable		 3brfA-3wxoA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7I_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		3 / 3 ARG A 404
ILE A 431
TRP A 432
 None
 1.14A 3e7iB-3wxoA:
undetectable		 3e7iB-3wxoA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		5 / 12 VAL A 241
ASP A 240
LEU A 329
PRO A 225
GLY A 227
 None
None
None
HEM  A 801 ( 4.2A)
None
 1.20A 3j6pB-3wxoA:
undetectable		 3j6pB-3wxoA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		5 / 12 GLY A 108
ALA A 215
ASP A 104
GLY A 187
ARG A 202
 NA  A 805 ( 4.8A)
None
None
None
None
 1.32A 3jzjA-3wxoA:
undetectable		 3jzjA-3wxoA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		5 / 12 LEU A 510
LEU A 503
SER A 520
GLY A 529
ALA A 466
 None
 1.06A 3kk6A-3wxoA:
undetectable		 3kk6A-3wxoA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		4 / 4 GLY A 107
TYR A 100
GLY A 105
ASP A 477
 NA  A 805 (-4.0A)
None
NA  A 805 (-4.7A)
None
 1.36A 3kl3A-3wxoA:
undetectable		 3kl3A-3wxoA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		4 / 4 GLY A 108
TYR A 100
GLY A 105
ASP A 477
 NA  A 805 ( 4.8A)
None
NA  A 805 (-4.7A)
None
 1.14A 3kl3A-3wxoA:
undetectable		 3kl3A-3wxoA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		5 / 12 VAL A 506
LEU A 510
LEU A 503
GLY A 529
ALA A 466
 None
 1.09A 3nt1A-3wxoA:
undetectable		 3nt1A-3wxoA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		5 / 12 VAL A 506
LEU A 510
LEU A 503
GLY A 529
ALA A 466
 None
 1.09A 3nt1B-3wxoA:
undetectable		 3nt1B-3wxoA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		5 / 12 VAL A 506
LEU A 510
LEU A 503
GLY A 529
ALA A 466
 None
 1.12A 3rr3C-3wxoA:
undetectable		 3rr3C-3wxoA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		5 / 12 VAL A 506
LEU A 510
LEU A 503
GLY A 529
ALA A 466
 None
 1.12A 3rr3D-3wxoA:
undetectable		 3rr3D-3wxoA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		4 / 6 ASN A 696
PHE A 639
ALA A 692
THR A 643
 NA  A 808 (-3.5A)
None
None
None
 1.07A 3t3sB-3wxoA:
undetectable		 3t3sB-3wxoA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		5 / 12 GLY A 616
LEU A 615
ASP A 468
SER A 464
PHE A 704
 None
 1.21A 3tbgC-3wxoA:
undetectable		 3tbgC-3wxoA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		5 / 12 ILE A 525
GLY A 481
ILE A 487
ARG A 716
LEU A 598
 None
 0.88A 3uj6A-3wxoA:
undetectable		 3uj6A-3wxoA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		3 / 3 LYS A 337
GLU A 347
TRP A 334
 None
 1.43A 3v4tH-3wxoA:
undetectable		 3v4tH-3wxoA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		3 / 3 ARG A 352
ASP A 322
GLN A 320
 None
NA  A 806 (-2.4A)
None
 0.90A 4azsA-3wxoA:
undetectable		 4azsA-3wxoA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA6_A_GA2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		5 / 9 SER A 201
VAL A 216
SER A 196
ASP A 229
VAL A 228
 None
 1.46A 4da6A-3wxoA:
undetectable		 4da6A-3wxoA:
16.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		5 / 6 ASP A  81
TYR A  85
LEU A  88
HIS A 269
THR A 307
 None
None
HEM  A 801 (-4.2A)
HEM  A 801 (-3.6A)
HEM  A 801 ( 3.3A)
 0.28A 4paeA-3wxoA:
66.9		 4paeA-3wxoA:
98.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3W_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		4 / 6 VAL A 463
TRP A 708
PHE A 704
GLU A 534
 None
 1.45A 4v3wA-3wxoA:
1.6
4v3wB-3wxoA:
1.1		 4v3wA-3wxoA:
20.25
4v3wB-3wxoA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		3 / 3 ARG A 471
ASP A 468
TRP A 467
 None
 1.10A 4xdqA-3wxoA:
undetectable		 4xdqA-3wxoA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		4 / 8 SER A 147
TYR A  51
ALA A  97
GLY A 110
 None
 0.77A 5albL-3wxoA:
undetectable		 5albL-3wxoA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		4 / 6 ILE A 387
PHE A 398
THR A 264
TRP A 321
 None
None
NA  A 806 (-4.7A)
None
 1.21A 5g08A-3wxoA:
undetectable		 5g08A-3wxoA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		4 / 6 PHE A 245
PHE A 398
THR A 264
TRP A 321
 HEM  A 801 (-4.6A)
None
NA  A 806 (-4.7A)
None
 0.93A 5g08A-3wxoA:
undetectable		 5g08A-3wxoA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		3 / 3 ARG A 471
HIS A 619
ARG A 576
 None
 0.93A 5iaoC-3wxoA:
undetectable		 5iaoC-3wxoA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		3 / 3 ARG A 471
HIS A 619
ARG A 576
 None
 0.94A 5iaoF-3wxoA:
undetectable		 5iaoF-3wxoA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		5 / 12 VAL A 506
LEU A 510
LEU A 503
GLY A 529
ALA A 466
 None
 1.09A 5jvzA-3wxoA:
0.8		 5jvzA-3wxoA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		5 / 12 VAL A 506
LEU A 510
LEU A 503
GLY A 529
ALA A 466
 None
 1.10A 5jvzB-3wxoA:
undetectable		 5jvzB-3wxoA:
19.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KSN_B_NIZB809_1
(CATALASE-PEROXIDASE)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		5 / 9 ARG A 106
GLU A 181
SER A 476
GLN A 596
LEU A 597
 None
None
NA  A 805 (-4.9A)
None
None
 1.28A 5ksnB-3wxoA:
44.3		 5ksnB-3wxoA:
61.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5SYI_A_NIZA805_1
(CATALASE-PEROXIDASE)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		4 / 5 ARG A  91
TRP A  94
HIS A  95
PRO A 225
 HEM  A 801 ( 4.6A)
HEM  A 801 (-3.5A)
None
HEM  A 801 ( 4.2A)
 0.18A 5syiA-3wxoA:
63.6		 5syiA-3wxoA:
61.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5SYI_B_NIZB806_1
(CATALASE-PEROXIDASE)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		5 / 5 ARG A  91
TRP A  94
HIS A  95
PRO A 225
SER A 308
 HEM  A 801 ( 4.6A)
HEM  A 801 (-3.5A)
None
HEM  A 801 ( 4.2A)
HEM  A 801 ( 2.6A)
 0.26A 5syiB-3wxoA:
63.1		 5syiB-3wxoA:
61.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5SYJ_A_NIZA810_1
(CATALASE-PEROXIDASE)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		6 / 6 ARG A  91
TRP A  94
HIS A  95
LEU A 220
PRO A 225
SER A 308
 HEM  A 801 ( 4.6A)
HEM  A 801 (-3.5A)
None
None
HEM  A 801 ( 4.2A)
HEM  A 801 ( 2.6A)
 0.25A 5syjA-3wxoA:
63.3		 5syjA-3wxoA:
61.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5SYJ_B_NIZB810_1
(CATALASE-PEROXIDASE)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		6 / 6 ARG A  91
TRP A  94
HIS A  95
LEU A 220
PRO A 225
SER A 308
 HEM  A 801 ( 4.6A)
HEM  A 801 (-3.5A)
None
None
HEM  A 801 ( 4.2A)
HEM  A 801 ( 2.6A)
 0.25A 5syjB-3wxoA:
63.1		 5syjB-3wxoA:
61.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		5 / 12 LEU A 615
LEU A 612
GLY A 611
GLY A 610
VAL A 607
 None
 1.02A 5uc1A-3wxoA:
undetectable		 5uc1A-3wxoA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		5 / 12 LEU A 615
LEU A 612
GLY A 611
GLY A 610
VAL A 607
 None
 1.02A 5uc1B-3wxoA:
undetectable		 5uc1B-3wxoA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_D_SAMD601_0
(NS5
METHYLTRANSFERASE)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		5 / 12 GLY A 324
GLY A 261
THR A 315
HIS A 317
ASP A 355
 None
None
NA  A 806 (-3.1A)
None
None
 1.05A 5wz1D-3wxoA:
undetectable		 5wz1D-3wxoA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_F_SAMF601_0
(NS5
METHYLTRANSFERASE)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		5 / 12 GLY A 324
GLY A 261
THR A 315
HIS A 317
ASP A 355
 None
None
NA  A 806 (-3.1A)
None
None
 1.04A 5wz1F-3wxoA:
undetectable		 5wz1F-3wxoA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		5 / 12 ALA A 153
GLY A 110
THR A 111
GLY A 108
PHE A 170
 None
None
None
NA  A 805 ( 4.8A)
None
 1.17A 5ybbA-3wxoA:
undetectable		 5ybbA-3wxoA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AY6_A_VORA501_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		5 / 9 TYR A 154
ALA A 109
ALA A 149
LEU A 146
LEU A 135
 None
 1.14A 6ay6A-3wxoA:
undetectable		 6ay6A-3wxoA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		3 / 3 TYR A 575
ALA A 707
LEU A 600
 None
 0.66A 6d9kF-3wxoA:
undetectable		 6d9kF-3wxoA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_1
(PROTEASE)		 3wxo CATALASE-PEROXIDASE
(Synechococcus
elongatus) 		5 / 12 GLY A 616
VAL A 533
GLY A 610
ILE A 609
VAL A 463
 None
 0.82A 6dh0B-3wxoA:
undetectable		 6dh0B-3wxoA:
8.86