SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wxw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3wxw ADIPONECTIN RECEPTOR
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A 322
ALA A 325
ALA A 326
LEU A 283
ALA A 279
 None
 0.69A 1fbyA-3wxwA:
undetectable		 1fbyA-3wxwA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3wxw ADIPONECTIN RECEPTOR
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A 322
ALA A 325
ALA A 326
LEU A 283
ALA A 279
 None
 0.71A 1fbyB-3wxwA:
undetectable		 1fbyB-3wxwA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3wxw ADIPONECTIN RECEPTOR
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A 322
ALA A 325
ALA A 326
LEU A 283
ALA A 279
 None
 0.67A 1fm6A-3wxwA:
undetectable		 1fm6A-3wxwA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3wxw ADIPONECTIN RECEPTOR
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A 322
ALA A 325
ALA A 326
LEU A 283
ALA A 279
 None
 0.66A 1fm9A-3wxwA:
undetectable		 1fm9A-3wxwA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3wxw ADIPONECTIN RECEPTOR
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A 322
ALA A 325
ALA A 326
LEU A 283
ALA A 279
 None
 0.70A 1k74A-3wxwA:
undetectable		 1k74A-3wxwA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_E_9CRE1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3wxw ADIPONECTIN RECEPTOR
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A 322
ALA A 325
ALA A 326
LEU A 283
ALA A 279
 None
 0.67A 1xdkE-3wxwA:
undetectable		 1xdkE-3wxwA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 3wxw ADIPONECTIN RECEPTOR
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A 322
ALA A 325
ALA A 326
LEU A 283
ALA A 279
 None
 0.70A 1xiuA-3wxwA:
undetectable		 1xiuA-3wxwA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3wxw ADIPONECTIN RECEPTOR
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A 322
ALA A 325
ALA A 326
LEU A 283
ALA A 279
 None
 0.68A 1xlsA-3wxwA:
undetectable		 1xlsA-3wxwA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3wxw ADIPONECTIN RECEPTOR
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A 322
ALA A 325
ALA A 326
LEU A 283
ALA A 279
 None
 0.69A 1xlsB-3wxwA:
undetectable		 1xlsB-3wxwA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3wxw ADIPONECTIN RECEPTOR
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A 322
ALA A 325
ALA A 326
LEU A 283
ALA A 279
 None
 0.69A 1xlsC-3wxwA:
undetectable		 1xlsC-3wxwA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3wxw ADIPONECTIN RECEPTOR
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A 322
ALA A 325
ALA A 326
LEU A 283
ALA A 279
 None
 0.69A 1xlsD-3wxwA:
undetectable		 1xlsD-3wxwA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3wxw ADIPONECTIN RECEPTOR
PROTEIN 2
(Homo
sapiens) 		5 / 12 ALA A 359
TYR A 321
TRP A 313
SER A 230
GLY A 358
 None
 1.40A 2dcfA-3wxwA:
undetectable		 2dcfA-3wxwA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA512_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3wxw ADIPONECTIN RECEPTOR
PROTEIN 2
(Homo
sapiens) 		5 / 10 ALA A 359
TYR A 321
TRP A 313
SER A 230
HIS A 362
 None
 1.35A 2zm8A-3wxwA:
undetectable		 2zm8A-3wxwA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3wxw ADIPONECTIN RECEPTOR
PROTEIN 2
(Homo
sapiens) 		5 / 10 ILE A 322
ALA A 325
ALA A 326
LEU A 283
ALA A 279
 None
 0.72A 3falC-3wxwA:
undetectable		 3falC-3wxwA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3wxw ADIPONECTIN RECEPTOR
PROTEIN 2
(Homo
sapiens) 		5 / 11 ILE A 322
ALA A 325
ALA A 326
LEU A 283
ALA A 279
 None
 0.73A 3fc6A-3wxwA:
undetectable		 3fc6A-3wxwA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 3wxw ADIPONECTIN RECEPTOR
PROTEIN 2
(Homo
sapiens) 		4 / 8 GLY A 229
ILE A 258
PHE A 269
PHE A 282
 None
 1.04A 3ko0B-3wxwA:
1.3
3ko0J-3wxwA:
1.4		 3ko0B-3wxwA:
18.22
3ko0J-3wxwA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3wxw ADIPONECTIN RECEPTOR
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A 322
ALA A 325
ALA A 326
LEU A 283
ALA A 279
 None
 0.67A 3oapA-3wxwA:
undetectable		 3oapA-3wxwA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA602_0
(LACCASE-1)		 3wxw ADIPONECTIN RECEPTOR
PROTEIN 2
(Homo
sapiens) 		3 / 3 HIS A 202
HIS A 352
HIS A 348
 ZN  A 401 (-3.5A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.5A)
 0.47A 3qpkA-3wxwA:
undetectable		 3qpkA-3wxwA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB602_0
(LACCASE-1)		 3wxw ADIPONECTIN RECEPTOR
PROTEIN 2
(Homo
sapiens) 		3 / 3 HIS A 202
HIS A 352
HIS A 348
 ZN  A 401 (-3.5A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.5A)
 0.46A 3qpkB-3wxwA:
undetectable		 3qpkB-3wxwA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 3wxw ADIPONECTIN RECEPTOR
PROTEIN 2
(Homo
sapiens) 		5 / 12 LEU A 225
GLY A 222
PHE A 197
ILE A 261
ALA A 260
 None
 1.05A 3uwlD-3wxwA:
undetectable		 3uwlD-3wxwA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 3wxw ADIPONECTIN RECEPTOR
PROTEIN 2
(Homo
sapiens) 		4 / 9 TYR A 321
HIS A 362
PHE A 231
ILE A 290
 None
 1.13A 4jvlA-3wxwA:
undetectable		 4jvlA-3wxwA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)		 3wxw ADIPONECTIN RECEPTOR
PROTEIN 2
(Homo
sapiens) 		5 / 12 LEU A 189
LEU A 186
GLY A 185
MET A 167
ILE A 164
 None
 1.40A 4oktA-3wxwA:
undetectable		 4oktA-3wxwA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3wxw ADIPONECTIN RECEPTOR
PROTEIN 2
(Homo
sapiens) 		5 / 12 LEU A 320
TYR A 321
VAL A 356
GLY A 358
ALA A 359
 None
 1.06A 4otyA-3wxwA:
undetectable		 4otyA-3wxwA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3wxw ADIPONECTIN RECEPTOR
PROTEIN 2
(Homo
sapiens) 		5 / 12 LEU A 320
TYR A 321
VAL A 356
GLY A 358
ALA A 359
 None
 1.02A 4otyB-3wxwA:
undetectable		 4otyB-3wxwA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3wxw ADIPONECTIN RECEPTOR
PROTEIN 2
(Homo
sapiens) 		4 / 5 TYR A 220
SER A 212
ASP A 117
ASP A 119
 None
 1.32A 4qtuB-3wxwA:
undetectable		 4qtuB-3wxwA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3wxw ADIPONECTIN RECEPTOR
PROTEIN 2
(Homo
sapiens) 		6 / 12 ALA A 318
PHE A 187
GLY A 229
PHE A 231
GLY A 286
LEU A 287
 None
 1.29A 5i73A-3wxwA:
2.0		 5i73A-3wxwA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA601_0
(LACCASE 2)		 3wxw ADIPONECTIN RECEPTOR
PROTEIN 2
(Homo
sapiens) 		3 / 3 HIS A 202
HIS A 352
HIS A 348
 ZN  A 401 (-3.5A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.5A)
 0.51A 5migA-3wxwA:
undetectable		 5migA-3wxwA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OCS_A_ACTA402_0
(PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE)		 3wxw ADIPONECTIN RECEPTOR
PROTEIN 2
(Homo
sapiens) 		4 / 5 CYH A 194
ILE A 223
HIS A 352
HIS A 202
 None
None
ZN  A 401 (-3.2A)
ZN  A 401 (-3.5A)
 1.43A 5ocsA-3wxwA:
undetectable		 5ocsA-3wxwA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3wxw ADIPONECTIN RECEPTOR
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A 322
ALA A 325
ALA A 326
LEU A 283
ALA A 279
 None
 0.73A 5uanA-3wxwA:
undetectable		 5uanA-3wxwA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3wxw ADIPONECTIN RECEPTOR
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A 322
ALA A 325
ALA A 326
LEU A 283
ALA A 279
 None
 0.69A 5z12B-3wxwA:
undetectable		 5z12B-3wxwA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3wxw ADIPONECTIN RECEPTOR
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A 322
ALA A 325
ALA A 326
LEU A 283
ALA A 279
 None
 0.65A 6a5yD-3wxwA:
undetectable		 6a5yD-3wxwA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3wxw ADIPONECTIN RECEPTOR
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A 322
ALA A 325
ALA A 326
LEU A 283
ALA A 279
 None
 0.75A 6a5zL-3wxwA:
undetectable		 6a5zL-3wxwA:
14.14