SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wxx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 3wxx ACRH
(Aeromonas
hydrophila) 		5 / 11 SER A  90
GLY A  75
GLY A  94
TYR A  38
PHE A 104
 None
 1.30A 1iolA-3wxxA:
undetectable		 1iolA-3wxxA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_B_DEXB2999_1
(GLUCOCORTICOID
RECEPTOR)		 3wxx ACRH
AOPB
(Aeromonas
hydrophila) 		5 / 12 GLY B 197
LEU A  74
ARG A  78
THR B 242
ILE B 239
 None
 1.49A 1p93B-3wxxB:
undetectable		 1p93B-3wxxB:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3wxx ACRH
(Aeromonas
hydrophila) 		5 / 12 LEU A 130
SER A 127
GLY A 146
ALA A 145
LEU A 141
 None
 0.89A 1pxxC-3wxxA:
undetectable		 1pxxC-3wxxA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3wxx ACRH
AOPB
(Aeromonas
hydrophila;
Aeromonas
hydrophila) 		5 / 12 LEU B  50
GLY A  41
LEU A  72
ALA A  53
GLY B  47
 None
 1.03A 2vmyA-3wxxB:
undetectable		 2vmyA-3wxxB:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 3wxx ACRH
AOPB
(Aeromonas
hydrophila) 		5 / 12 ALA B 235
ALA B 178
VAL B 175
LEU A  74
LEU A  86
 None
 1.31A 3b0wB-3wxxB:
undetectable		 3b0wB-3wxxB:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 3wxx AOPB
(Aeromonas
hydrophila) 		5 / 12 VAL B 255
ALA B 178
GLU B 231
ILE B 171
THR B 259
 None
 1.06A 3dl9A-3wxxB:
undetectable		 3dl9A-3wxxB:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 3wxx AOPB
(Aeromonas
hydrophila) 		5 / 12 VAL B 255
ALA B 178
GLU B 231
ILE B 171
THR B 259
 None
 1.09A 3dl9B-3wxxB:
undetectable		 3dl9B-3wxxB:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 3wxx ACRH
(Aeromonas
hydrophila) 		5 / 12 ALA A  24
GLY A  21
GLY A  20
ASP A  28
ASP A  64
 None
 1.10A 3m6vB-3wxxA:
undetectable		 3m6vB-3wxxA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3wxx AOPB
(Aeromonas
hydrophila) 		5 / 12 VAL B 241
ALA B 240
GLY B 244
ALA B  99
LEU B  86
 None
 1.21A 3qxyA-3wxxB:
undetectable		 3qxyA-3wxxB:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_A_BEZA264_0
(ECHA1_1)		 3wxx ACRH
AOPB
(Aeromonas
hydrophila;
Aeromonas
hydrophila) 		4 / 8 ALA B 188
ILE B 239
LEU A  17
ALA B 182
 None
 0.75A 3r9tA-3wxxB:
undetectable		 3r9tA-3wxxB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3wxx AOPB
(Aeromonas
hydrophila) 		5 / 11 VAL B 241
ALA B 240
GLY B 244
ALA B  99
LEU B  86
 None
 1.25A 3rc0A-3wxxB:
undetectable		 3rc0A-3wxxB:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 3wxx ACRH
AOPB
(Aeromonas
hydrophila) 		5 / 12 ALA B  76
LEU A  34
ARG A  69
ILE A  56
THR B  75
 None
 1.09A 4dfrB-3wxxB:
undetectable		 4dfrB-3wxxB:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA610_0
(SERUM ALBUMIN)		 3wxx ACRH
(Aeromonas
hydrophila) 		3 / 3 VAL A  29
SER A  30
THR A  33
 None
 0.35A 4luhA-3wxxA:
2.4		 4luhA-3wxxA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3wxx ACRH
AOPB
(Aeromonas
hydrophila;
Aeromonas
hydrophila) 		5 / 12 ALA B 191
GLY B 184
GLY B 186
ILE A  13
LEU A  26
 None
 1.00A 4n49A-3wxxB:
undetectable		 4n49A-3wxxB:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3wxx ACRH
(Aeromonas
hydrophila) 		5 / 12 LEU A 130
SER A 127
GLY A 146
ALA A 145
LEU A 141
 None
 0.86A 4otyA-3wxxA:
undetectable		 4otyA-3wxxA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3wxx ACRH
(Aeromonas
hydrophila) 		5 / 12 LEU A 130
SER A 127
GLY A 146
ALA A 145
LEU A 141
 None
 0.89A 4otyB-3wxxA:
undetectable		 4otyB-3wxxA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3wxx AOPB
(Aeromonas
hydrophila) 		5 / 9 ALA B 247
THR B 250
ALA B 248
GLY B 184
ALA B 188
 None
 1.21A 4qvnK-3wxxB:
undetectable
4qvnL-3wxxB:
undetectable		 4qvnK-3wxxB:
21.76
4qvnL-3wxxB:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3wxx AOPB
(Aeromonas
hydrophila) 		5 / 9 ALA B 247
THR B 250
ALA B 248
GLY B 184
ALA B 188
 None
 1.21A 4qvnY-3wxxB:
undetectable
4qvnZ-3wxxB:
undetectable		 4qvnY-3wxxB:
21.76
4qvnZ-3wxxB:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3wxx ACRH
(Aeromonas
hydrophila) 		5 / 12 LEU A 130
SER A 127
GLY A 146
ALA A 145
LEU A 141
 None
 0.90A 4rrwD-3wxxA:
undetectable		 4rrwD-3wxxA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3wxx ACRH
(Aeromonas
hydrophila) 		5 / 12 LEU A 130
SER A 127
GLY A 146
ALA A 145
LEU A 141
 None
 0.90A 4rrzD-3wxxA:
undetectable		 4rrzD-3wxxA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3wxx ACRH
(Aeromonas
hydrophila) 		5 / 9 LEU A 130
SER A 127
GLY A 146
ALA A 145
LEU A 141
 None
 0.95A 4rs0A-3wxxA:
undetectable		 4rs0A-3wxxA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 3wxx ACRH
AOPB
(Aeromonas
hydrophila) 		5 / 12 ILE B 239
ALA B 235
MET B 192
HIS A  65
PHE B 243
 None
 1.46A 4zo1X-3wxxB:
undetectable		 4zo1X-3wxxB:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 3wxx ACRH
AOPB
(Aeromonas
hydrophila;
Aeromonas
hydrophila) 		3 / 3 MET B 204
HIS A  54
GLY B 196
 None
 0.69A 5gwzB-3wxxB:
undetectable		 5gwzB-3wxxB:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 3wxx ACRH
AOPB
(Aeromonas
hydrophila) 		6 / 10 ILE A  56
VAL A  29
LEU B  72
LEU B  69
LEU A  60
LEU A  63
 None
 1.38A 6f6nA-3wxxA:
undetectable
6f6nB-3wxxA:
undetectable		 6f6nA-3wxxA:
17.61
6f6nB-3wxxA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GZ9_A_TXCA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 3wxx ACRH
AOPB
(Aeromonas
hydrophila;
Aeromonas
hydrophila) 		5 / 10 VAL B 241
ASN B  82
ALA B  83
GLN B  77
ASN A  27
 None
 1.32A 6gz9A-3wxxB:
0.0		 6gz9A-3wxxB:
16.97