SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wya'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 3wya ELONGATION FACTOR
1-ALPHA
(Pyrococcus
horikoshii) 		5 / 7 ILE A  13
PRO A 176
ILE A 178
LEU A 203
ILE A 140
 None
 1.39A 2q83A-3wyaA:
undetectable		 2q83A-3wyaA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 3wya ELONGATION FACTOR
1-ALPHA
(Pyrococcus
horikoshii) 		4 / 7 ILE A 301
ILE A 289
LEU A 247
ILE A 223
 None
 0.81A 2q83A-3wyaA:
undetectable		 2q83A-3wyaA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 3wya ELONGATION FACTOR
1-ALPHA
(Pyrococcus
horikoshii) 		5 / 12 ILE A  24
PHE A  12
THR A 142
ILE A 140
LEU A 207
 None
 1.05A 2w3bA-3wyaA:
undetectable		 2w3bA-3wyaA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 3wya ELONGATION FACTOR
1-ALPHA
(Pyrococcus
horikoshii) 		5 / 12 ILE A 139
ALA A 109
LEU A 207
PHE A  12
ASN A 144
 None
None
None
None
GDP  A 500 (-3.0A)
 1.19A 2w3mB-3wyaA:
undetectable		 2w3mB-3wyaA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 3wya ELONGATION FACTOR
1-ALPHA
(Pyrococcus
horikoshii) 		4 / 8 ILE A  85
PHE A  12
VAL A 188
LEU A 203
 None
 0.85A 2w98B-3wyaA:
2.1		 2w98B-3wyaA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XPW_A_OTCA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 3wya ELONGATION FACTOR
1-ALPHA
(Pyrococcus
horikoshii) 		5 / 12 PHE A 407
ARG A 388
PRO A 389
VAL A 393
ILE A 424
 None
 1.48A 2xpwA-3wyaA:
undetectable		 2xpwA-3wyaA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 3wya ELONGATION FACTOR
1-ALPHA
(Pyrococcus
horikoshii) 		5 / 10 PHE A 323
ILE A 422
VAL A 421
LEU A 387
PHE A 407
 None
 1.19A 3ay0A-3wyaA:
2.0		 3ay0A-3wyaA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 3wya ELONGATION FACTOR
1-ALPHA
(Pyrococcus
horikoshii) 		5 / 10 PHE A 323
ILE A 422
VAL A 421
LEU A 387
PHE A 407
 None
 1.22A 3ay0B-3wyaA:
2.0		 3ay0B-3wyaA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 3wya ELONGATION FACTOR
1-ALPHA
(Pyrococcus
horikoshii) 		4 / 4 GLY A 367
VAL A 362
GLY A 380
THR A 379
 None
 0.91A 3ib2A-3wyaA:
undetectable		 3ib2A-3wyaA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3wya ELONGATION FACTOR
1-ALPHA
(Pyrococcus
horikoshii) 		5 / 12 ILE A  24
PHE A  12
THR A 142
ILE A 140
LEU A 207
 None
 1.10A 4ej1B-3wyaA:
undetectable		 4ej1B-3wyaA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 3wya ELONGATION FACTOR
1-ALPHA
(Pyrococcus
horikoshii) 		5 / 12 ILE A  24
PHE A  12
THR A 142
ILE A 140
LEU A 207
 None
 1.03A 4kebB-3wyaA:
undetectable		 4kebB-3wyaA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3wya ELONGATION FACTOR
1-ALPHA
(Pyrococcus
horikoshii) 		5 / 12 ILE A  24
PHE A  12
THR A 142
ILE A 140
LEU A 207
 None
 1.06A 4m6kA-3wyaA:
undetectable		 4m6kA-3wyaA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3wya ELONGATION FACTOR
1-ALPHA
(Pyrococcus
horikoshii) 		5 / 12 ILE A  24
PHE A  12
THR A 142
ILE A 140
LEU A 207
 None
 1.14A 4qlgB-3wyaA:
undetectable		 4qlgB-3wyaA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 3wya ELONGATION FACTOR
1-ALPHA
(Pyrococcus
horikoshii) 		4 / 6 GLY A 290
GLU A 274
PHE A 291
TYR A 229
 None
 0.91A 5kmfA-3wyaA:
undetectable
5kmfC-3wyaA:
undetectable		 5kmfA-3wyaA:
20.54
5kmfC-3wyaA:
20.54