SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wyd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 3wyd LC-EST1C
(uncultured
organism) 		5 / 10 GLY A 327
SER A 399
MET A 400
THR A 449
HIS A 479
 None
 0.75A 1a8uA-3wydA:
16.0		 1a8uA-3wydA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 3wyd LC-EST1C
(uncultured
organism) 		5 / 10 GLY A 327
SER A 399
MET A 400
THR A 449
HIS A 479
 None
 0.74A 1a8uB-3wydA:
15.8		 1a8uB-3wydA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3wyd LC-EST1C
(uncultured
organism) 		4 / 5 GLU A 473
PRO A 475
ILE A 474
GLY A 444
 None
 1.07A 2qeuA-3wydA:
undetectable
2qeuC-3wydA:
undetectable		 2qeuA-3wydA:
20.70
2qeuC-3wydA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3wyd LC-EST1C
(uncultured
organism) 		5 / 10 ILE A 393
LEU A 325
ILE A 379
SER A 407
PHE A 416
 None
 1.16A 2w9sC-3wydA:
undetectable		 2w9sC-3wydA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3wyd LC-EST1C
(uncultured
organism) 		5 / 12 HIS A 479
ASP A 447
GLY A 327
SER A 399
ALA A 483
 None
 0.94A 3sueA-3wydA:
undetectable		 3sueA-3wydA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3wyd LC-EST1C
(uncultured
organism) 		5 / 12 HIS A 479
ASP A 447
GLY A 327
SER A 399
ALA A 483
 None
 0.92A 3sueB-3wydA:
undetectable		 3sueB-3wydA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3wyd LC-EST1C
(uncultured
organism) 		5 / 12 HIS A 479
ASP A 447
GLY A 327
SER A 399
ALA A 483
 None
 0.91A 3sufB-3wydA:
undetectable		 3sufB-3wydA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3wyd LC-EST1C
(uncultured
organism) 		4 / 7 PHE A 336
GLU A 349
ARG A 306
VAL A 355
 None
 1.47A 3uftA-3wydA:
undetectable
3uftB-3wydA:
undetectable		 3uftA-3wydA:
18.54
3uftB-3wydA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CDT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3wyd LC-EST1C
(uncultured
organism) 		4 / 7 ARG A 306
VAL A 355
PHE A 336
GLU A 349
 None
 1.43A 4cdtA-3wydA:
undetectable
4cdtB-3wydA:
undetectable		 4cdtA-3wydA:
18.54
4cdtB-3wydA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 3wyd LC-EST1C
(uncultured
organism) 		5 / 11 VAL A 422
ALA A 483
THR A 486
HIS A 443
VAL A 442
 None
 1.22A 4e0fA-3wydA:
undetectable		 4e0fA-3wydA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSH_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3wyd LC-EST1C
(uncultured
organism) 		4 / 6 PHE A 336
GLU A 349
ARG A 306
VAL A 355
 None
 1.45A 4jshA-3wydA:
undetectable
4jshB-3wydA:
undetectable		 4jshA-3wydA:
18.54
4jshB-3wydA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCI_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3wyd LC-EST1C
(uncultured
organism) 		4 / 7 PHE A 336
GLU A 349
ARG A 306
VAL A 355
 None
 1.48A 4kciA-3wydA:
undetectable
4kciB-3wydA:
undetectable		 4kciA-3wydA:
18.54
4kciB-3wydA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 3wyd LC-EST1C
(uncultured
organism) 		5 / 12 VAL A 355
TYR A 308
VAL A 309
PHE A 491
GLY A 352
 None
 1.20A 4mm4B-3wydA:
undetectable		 4mm4B-3wydA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD9_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3wyd LC-EST1C
(uncultured
organism) 		4 / 6 PHE A 336
GLU A 349
ARG A 306
VAL A 355
 None
 1.42A 5ad9A-3wydA:
undetectable
5ad9B-3wydA:
undetectable		 5ad9A-3wydA:
18.54
5ad9B-3wydA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3wyd LC-EST1C
(uncultured
organism) 		4 / 7 ARG A 306
VAL A 355
PHE A 336
GLU A 349
 None
 1.48A 5unxA-3wydA:
undetectable
5unxB-3wydA:
undetectable		 5unxA-3wydA:
18.54
5unxB-3wydA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO6_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3wyd LC-EST1C
(uncultured
organism) 		4 / 7 PHE A 336
GLU A 349
ARG A 306
VAL A 355
 None
 1.48A 5uo6A-3wydA:
undetectable
5uo6B-3wydA:
undetectable		 5uo6A-3wydA:
21.43
5uo6B-3wydA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3wyd LC-EST1C
(uncultured
organism) 		4 / 7 PHE A 336
GLU A 349
ARG A 306
VAL A 355
 None
 1.43A 5uo7A-3wydA:
undetectable
5uo7B-3wydA:
undetectable		 5uo7A-3wydA:
21.43
5uo7B-3wydA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV5_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3wyd LC-EST1C
(uncultured
organism) 		4 / 7 PHE A 336
GLU A 349
ARG A 306
VAL A 355
 None
 1.42A 5vv5A-3wydA:
undetectable
5vv5B-3wydA:
undetectable		 5vv5A-3wydA:
21.43
5vv5B-3wydA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV1_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3wyd LC-EST1C
(uncultured
organism) 		4 / 7 PHE A 336
GLU A 349
ARG A 306
VAL A 355
 None
 1.44A 6av1A-3wydA:
undetectable
6av1B-3wydA:
undetectable		 6av1A-3wydA:
14.98
6av1B-3wydA:
14.98