SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wyf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3wyf RAN-SPECIFIC
GTPASE-ACTIVATING
PROTEIN 2
(Saccharomyces
cerevisiae) 		5 / 12 PHE B 274
ILE B 268
LEU B 222
VAL B 276
ILE B 290
 None
 1.03A 1epbA-3wyfB:
2.1		 1epbA-3wyfB:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3wyf RAN-SPECIFIC
GTPASE-ACTIVATING
PROTEIN 2
(Saccharomyces
cerevisiae) 		5 / 12 PHE B 274
ILE B 268
LEU B 222
VAL B 276
ILE B 290
 None
 0.99A 1epbB-3wyfB:
undetectable		 1epbB-3wyfB:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 3wyf GSP1P
RAN-SPECIFIC
GTPASE-ACTIVATING
PROTEIN 2
(Saccharomyces
cerevisiae) 		4 / 8 TYR B 223
LEU A 211
SER B 283
GLU B 287
 None
 1.06A 1i7zA-3wyfB:
undetectable		 1i7zA-3wyfB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 3wyf GSP1P
(Saccharomyces
cerevisiae) 		3 / 3 ALA A  69
VAL A  18
TRP A 106
 GTP  A 301 ( 4.9A)
None
None
 0.81A 1jnoA-3wyfA:
undetectable		 1jnoA-3wyfA:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 3wyf GSP1P
(Saccharomyces
cerevisiae) 		3 / 3 ALA A  69
VAL A  18
TRP A 106
 GTP  A 301 ( 4.9A)
None
None
 0.81A 1jnoB-3wyfA:
undetectable		 1jnoB-3wyfA:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_A_DVAA6_0
(GRAMICIDIN B)		 3wyf GSP1P
(Saccharomyces
cerevisiae) 		3 / 3 ALA A  69
VAL A  18
TRP A 106
 GTP  A 301 ( 4.9A)
None
None
 0.89A 1jo3A-3wyfA:
undetectable		 1jo3A-3wyfA:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_B_DVAB6_0
(GRAMICIDIN B)		 3wyf GSP1P
(Saccharomyces
cerevisiae) 		3 / 3 ALA A  69
VAL A  18
TRP A 106
 GTP  A 301 ( 4.9A)
None
None
 0.88A 1jo3B-3wyfA:
undetectable		 1jo3B-3wyfA:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 3wyf GSP1P
(Saccharomyces
cerevisiae) 		3 / 3 ALA A  69
VAL A  18
TRP A 106
 GTP  A 301 ( 4.9A)
None
None
 0.87A 1magA-3wyfA:
undetectable		 1magA-3wyfA:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 3wyf GSP1P
(Saccharomyces
cerevisiae) 		3 / 3 ALA A  69
VAL A  18
TRP A 106
 GTP  A 301 ( 4.9A)
None
None
 0.87A 1magB-3wyfA:
undetectable		 1magB-3wyfA:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 3wyf GSP1P
(Saccharomyces
cerevisiae) 		3 / 3 ALA A  69
VAL A  18
TRP A 106
 GTP  A 301 ( 4.9A)
None
None
 0.83A 1ng8A-3wyfA:
undetectable		 1ng8A-3wyfA:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 3wyf GSP1P
(Saccharomyces
cerevisiae) 		3 / 3 ALA A  69
VAL A  18
TRP A 106
 GTP  A 301 ( 4.9A)
None
None
 0.83A 1ng8B-3wyfA:
undetectable		 1ng8B-3wyfA:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)		 3wyf GSP1P
(Saccharomyces
cerevisiae) 		3 / 3 ALA A  69
VAL A  18
TRP A 106
 GTP  A 301 ( 4.9A)
None
None
 0.86A 1nruA-3wyfA:
undetectable		 1nruA-3wyfA:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)		 3wyf GSP1P
(Saccharomyces
cerevisiae) 		3 / 3 ALA A  69
VAL A  18
TRP A 106
 GTP  A 301 ( 4.9A)
None
None
 0.87A 1nruB-3wyfA:
undetectable		 1nruB-3wyfA:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 3wyf GSP1P
(Saccharomyces
cerevisiae) 		5 / 12 THR A  44
GLY A  24
GLY A  22
GLY A  70
ASP A 127
 MG  A 302 ( 2.9A)
GTP  A 301 (-3.4A)
GTP  A 301 (-3.6A)
GTP  A 301 (-3.4A)
GTP  A 301 (-2.9A)
 1.00A 2b25A-3wyfA:
undetectable		 2b25A-3wyfA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)		 3wyf GSP1P
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 144
ARG A 108
VAL A 111
 None
 0.99A 2r2vC-3wyfA:
undetectable
2r2vD-3wyfA:
undetectable		 2r2vC-3wyfA:
9.30
2r2vD-3wyfA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 3wyf GSP1P
(Saccharomyces
cerevisiae) 		5 / 12 GLN A 147
ILE A 151
LEU A  17
VAL A  16
ILE A  90
 None
 1.10A 3gwxB-3wyfA:
undetectable		 3gwxB-3wyfA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3wyf RAN-SPECIFIC
GTPASE-ACTIVATING
PROTEIN 2
(Saccharomyces
cerevisiae) 		4 / 6 ALA B 220
LYS B 307
THR B 313
THR B 314
 None
 1.34A 4z4fA-3wyfB:
undetectable		 4z4fA-3wyfB:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 3wyf GSP1P
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 135
ARG A 131
HIS A 141
THR A 139
 None
 1.29A 5db5A-3wyfA:
3.7
5db5B-3wyfA:
undetectable		 5db5A-3wyfA:
20.51
5db5B-3wyfA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3wyf GSP1P
(Saccharomyces
cerevisiae) 		4 / 6 VAL A  10
LEU A  52
SER A  53
PHE A 163
 None
 0.86A 5jw1A-3wyfA:
undetectable		 5jw1A-3wyfA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 3wyf GSP1P
(Saccharomyces
cerevisiae) 		5 / 12 LYS A 161
PHE A 159
ASP A  93
VAL A  94
THR A  95
 None
 1.07A 5kpcB-3wyfA:
undetectable		 5kpcB-3wyfA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 3wyf GSP1P
(Saccharomyces
cerevisiae) 		5 / 12 LYS A 161
PHE A 159
GLY A 123
VAL A  94
THR A  95
 None
 1.17A 5kpcB-3wyfA:
undetectable		 5kpcB-3wyfA:
17.59