SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wyh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3wyh LYSOZYME G
(Struthio
camelus) 		5 / 12 TYR A 169
VAL A   8
ASP A  62
ALA A 146
SER A 145
 TAM  A 201 ( 4.5A)
None
None
None
None
 1.33A 1kiaD-3wyhA:
undetectable		 1kiaD-3wyhA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3wyh LYSOZYME G
(Struthio
camelus) 		5 / 12 TYR A 169
VAL A   8
ASP A  62
ALA A 146
SER A 145
 TAM  A 201 ( 4.5A)
None
None
None
None
 1.30A 1nbhC-3wyhA:
undetectable		 1nbhC-3wyhA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 3wyh LYSOZYME G
(Struthio
camelus) 		5 / 12 VAL A 173
ILE A  70
ILE A  66
VAL A  61
ILE A  52
 None
 1.35A 1r5lA-3wyhA:
undetectable		 1r5lA-3wyhA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2434_1
(CHITINASE)		 3wyh LYSOZYME G
(Struthio
camelus) 		4 / 6 GLU A  73
TYR A 147
ASP A  97
ARG A  99
 TAM  A 201 (-2.9A)
P6G  A 202 ( 3.5A)
TAM  A 201 ( 3.4A)
None
 1.41A 2a3bB-3wyhA:
undetectable		 2a3bB-3wyhA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3wyh LYSOZYME G
(Struthio
camelus) 		5 / 12 ILE A 144
GLY A 150
GLY A 143
SER A 100
ASN A 148
 None
P6G  A 202 (-3.4A)
None
None
TAM  A 201 ( 3.5A)
 1.14A 2okcA-3wyhA:
undetectable		 2okcA-3wyhA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3wyh LYSOZYME G
(Struthio
camelus) 		5 / 12 ILE A 144
GLY A 150
GLY A 143
SER A 100
ASN A 148
 None
P6G  A 202 (-3.4A)
None
None
TAM  A 201 ( 3.5A)
 1.15A 2okcB-3wyhA:
undetectable		 2okcB-3wyhA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3wyh LYSOZYME G
(Struthio
camelus) 		5 / 12 ALA A  64
PRO A  63
VAL A  65
THR A  13
ASP A   7
 None
 1.30A 2v95A-3wyhA:
undetectable		 2v95A-3wyhA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3wyh LYSOZYME G
(Struthio
camelus) 		5 / 12 ILE A 127
GLN A 128
GLY A   6
ASP A   7
LEU A 120
 None
 1.04A 2zw9A-3wyhA:
undetectable		 2zw9A-3wyhA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3wyh LYSOZYME G
(Struthio
camelus) 		6 / 12 GLY A 105
TYR A 180
GLY A  77
ALA A  76
GLY A 109
LEU A 113
 None
 1.21A 3hs6B-3wyhA:
undetectable		 3hs6B-3wyhA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 3wyh LYSOZYME G
(Struthio
camelus) 		4 / 8 ILE A 127
ILE A 124
VAL A 154
ILE A 144
 None
 0.88A 3p4wC-3wyhA:
undetectable		 3p4wC-3wyhA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 3wyh LYSOZYME G
(Struthio
camelus) 		5 / 10 ARG A  35
HIS A 183
GLY A 184
TYR A 185
ALA A  38
 None
 1.42A 3pp7B-3wyhA:
undetectable		 3pp7B-3wyhA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7G_A_ACTA514_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3wyh LYSOZYME G
(Struthio
camelus) 		4 / 4 ALA A  64
VAL A  65
ASP A  62
LEU A 140
 None
 1.25A 4e7gA-3wyhA:
undetectable		 4e7gA-3wyhA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 3wyh LYSOZYME G
(Struthio
camelus) 		4 / 6 ARG A 176
ALA A  33
ASP A 172
LEU A  26
 None
 1.12A 4ot2A-3wyhA:
undetectable		 4ot2A-3wyhA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3wyh LYSOZYME G
(Struthio
camelus) 		4 / 4 LEU A  51
ILE A  52
GLY A 109
ILE A  70
 None
 0.87A 5dzk3-3wyhA:
undetectable
5dzkm-3wyhA:
undetectable		 5dzk3-3wyhA:
2.50
5dzkm-3wyhA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3wyh LYSOZYME G
(Struthio
camelus) 		4 / 5 ILE A  52
GLY A 109
ILE A  70
LEU A  51
 None
 0.89A 5dzkd-3wyhA:
undetectable
5dzkk-3wyhA:
undetectable
5dzky-3wyhA:
undetectable		 5dzkd-3wyhA:
21.83
5dzkk-3wyhA:
21.95
5dzky-3wyhA:
2.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 3wyh LYSOZYME G
(Struthio
camelus) 		4 / 6 GLY A  15
THR A  13
SER A  34
VAL A  31
 None
 0.92A 5ewuA-3wyhA:
undetectable		 5ewuA-3wyhA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 3wyh LYSOZYME G
(Struthio
camelus) 		5 / 10 ILE A  69
ILE A  70
MET A  94
TYR A 185
ILE A  52
 None
 1.30A 5mzrA-3wyhA:
undetectable		 5mzrA-3wyhA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)		 3wyh LYSOZYME G
(Struthio
camelus) 		5 / 10 ILE A  69
ILE A  70
MET A  94
TYR A 185
ILE A  52
 None
 1.28A 5mzrC-3wyhA:
undetectable		 5mzrC-3wyhA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 3wyh LYSOZYME G
(Struthio
camelus) 		5 / 9 ILE A  69
ILE A  70
MET A  94
TYR A 185
ILE A  52
 None
 1.30A 5mzrD-3wyhA:
undetectable		 5mzrD-3wyhA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3wyh LYSOZYME G
(Struthio
camelus) 		5 / 12 LEU A 113
SER A  71
ALA A  64
ALA A  67
GLY A  68
 None
 1.12A 5tzoB-3wyhA:
undetectable		 5tzoB-3wyhA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 3wyh LYSOZYME G
(Struthio
camelus) 		5 / 12 ALA A  67
GLY A  68
SER A  71
LEU A  93
ASP A  46
 None
 1.08A 5w7pA-3wyhA:
undetectable		 5w7pA-3wyhA:
19.53