SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wyw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_ACTA600_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 3wyw GLUTATHIONE
S-TRANSFERASE
(Nilaparvata
lugens) 		4 / 5 LEU A 156
VAL A  95
TYR A  85
THR A 155
 None
 1.39A 1nw3A-3wywA:
undetectable		 1nw3A-3wywA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 3wyw GLUTATHIONE
S-TRANSFERASE
(Nilaparvata
lugens) 		4 / 8 SER A  67
ARG A  68
ALA A  12
THR A 167
 GSH  A 301 (-2.6A)
GSH  A 301 (-3.7A)
None
None
 0.92A 3bpxA-3wywA:
undetectable
3bpxB-3wywA:
1.7		 3bpxA-3wywA:
20.19
3bpxB-3wywA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3wyw GLUTATHIONE
S-TRANSFERASE
(Nilaparvata
lugens) 		4 / 7 GLY A 202
GLY A 205
THR A 167
GLU A 197
 None
 0.75A 3fpjB-3wywA:
2.3		 3fpjB-3wywA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3wyw GLUTATHIONE
S-TRANSFERASE
(Nilaparvata
lugens) 		5 / 12 PHE A 110
GLY A 207
ALA A 170
ILE A 165
ILE A 161
 None
 1.41A 3ld6A-3wywA:
undetectable		 3ld6A-3wywA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3wyw GLUTATHIONE
S-TRANSFERASE
(Nilaparvata
lugens) 		5 / 12 LEU A 175
TYR A 178
ILE A 165
ASP A 134
ALA A 135
 None
 1.17A 3uj7A-3wywA:
undetectable		 3uj7A-3wywA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 3wyw GLUTATHIONE
S-TRANSFERASE
(Nilaparvata
lugens) 		5 / 9 TYR A 107
VAL A 171
ALA A 170
GLY A 111
SER A 164
 None
 1.20A 4mmeA-3wywA:
undetectable		 4mmeA-3wywA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 3wyw GLUTATHIONE
S-TRANSFERASE
(Nilaparvata
lugens) 		5 / 9 TYR A 107
VAL A 171
ALA A 170
GLY A 111
SER A 164
 None
 1.20A 4mmeB-3wywA:
undetectable		 4mmeB-3wywA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		 3wyw GLUTATHIONE
S-TRANSFERASE
(Nilaparvata
lugens) 		5 / 9 TYR A 107
VAL A 171
ALA A 170
GLY A 111
SER A 164
 None
 1.18A 4mmfA-3wywA:
undetectable		 4mmfA-3wywA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 3wyw GLUTATHIONE
S-TRANSFERASE
(Nilaparvata
lugens) 		5 / 9 TYR A 107
VAL A 171
ALA A 170
GLY A 111
SER A 164
 None
 1.18A 4mmfB-3wywA:
undetectable		 4mmfB-3wywA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5US8_B_ADNB503_1
(ARGININOSUCCINATE
SYNTHASE)		 3wyw GLUTATHIONE
S-TRANSFERASE
(Nilaparvata
lugens) 		5 / 10 GLU A 197
GLU A 201
ARG A  15
LYS A 204
GLU A 200
 None
 1.40A 5us8A-3wywA:
0.0
5us8B-3wywA:
0.0		 5us8A-3wywA:
18.78
5us8B-3wywA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_F_BEZF201_0
(NS3 PROTEASE)		 3wyw GLUTATHIONE
S-TRANSFERASE
(Nilaparvata
lugens) 		4 / 5 ALA A 163
SER A 166
TYR A 185
TYR A 195
 None
 1.41A 5yodF-3wywA:
undetectable		 5yodF-3wywA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 3wyw GLUTATHIONE
S-TRANSFERASE
(Nilaparvata
lugens) 		4 / 7 GLN A 208
GLY A 205
PHE A 206
VAL A   8
 None
 0.91A 6hu9S-3wywA:
undetectable
6hu9q-3wywA:
1.6		 6hu9S-3wywA:
17.13
6hu9q-3wywA:
20.54