SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wyz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 3wyz RIBONUCLEASE P
PROTEIN COMPONENT 3
(Thermococcus
kodakarensis) 		4 / 7 ALA A 205
SER A 208
ILE A 175
ILE A 198
 None
 0.76A 1yc5A-3wyzA:
undetectable		 1yc5A-3wyzA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 3wyz RIBONUCLEASE P
PROTEIN COMPONENT 3
(Thermococcus
kodakarensis) 		5 / 10 LEU A  69
LEU A  67
SER A  50
LEU A  51
LEU A  40
 None
 0.88A 2xn7A-3wyzA:
undetectable
2xn7B-3wyzA:
undetectable		 2xn7A-3wyzA:
22.25
2xn7B-3wyzA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3wyz RIBONUCLEASE P
PROTEIN COMPONENT 3
(Thermococcus
kodakarensis) 		3 / 3 ALA A 153
ARG A 157
LYS A 161
 None
 0.55A 3kp3B-3wyzA:
undetectable		 3kp3B-3wyzA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 3wyz RIBONUCLEASE P
PROTEIN COMPONENT 3
(Thermococcus
kodakarensis) 		5 / 12 ARG A  19
GLY A  93
ILE A  98
VAL A  91
ILE A  77
 GOL  A 301 (-2.9A)
None
None
None
None
 1.04A 4aztA-3wyzA:
undetectable		 4aztA-3wyzA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3wyz RIBONUCLEASE P
PROTEIN COMPONENT 3
(Thermococcus
kodakarensis) 		4 / 5 ASN A  99
PRO A 113
GLY A  94
ASP A 119
 None
 1.00A 4n48B-3wyzA:
undetectable		 4n48B-3wyzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)		 3wyz RIBONUCLEASE P
PROTEIN COMPONENT 3
(Thermococcus
kodakarensis) 		5 / 12 GLY A  93
GLN A  92
LEU A 110
ARG A  19
THR A 162
 None
GOL  A 301 (-2.5A)
None
GOL  A 301 (-2.9A)
None
 1.40A 4okbA-3wyzA:
undetectable		 4okbA-3wyzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3wyz RIBONUCLEASE P
PROTEIN COMPONENT 3
(Thermococcus
kodakarensis) 		4 / 7 SER A 178
THR A 176
PHE A 174
ILE A 198
 GOL  A 301 (-3.7A)
None
None
None
 1.23A 5vkqA-3wyzA:
undetectable
5vkqB-3wyzA:
undetectable		 5vkqA-3wyzA:
8.95
5vkqB-3wyzA:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3wyz RIBONUCLEASE P
PROTEIN COMPONENT 3
(Thermococcus
kodakarensis) 		4 / 7 SER A 178
THR A 176
PHE A 174
ILE A 198
 GOL  A 301 (-3.7A)
None
None
None
 1.22A 5vkqC-3wyzA:
undetectable
5vkqD-3wyzA:
undetectable		 5vkqC-3wyzA:
8.95
5vkqD-3wyzA:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 3wyz RIBONUCLEASE P
PROTEIN COMPONENT 3
(Thermococcus
kodakarensis) 		3 / 3 ARG A 117
PHE A 158
GLY A 121
 None
 0.82A 6fgdA-3wyzA:
undetectable		 6fgdA-3wyzA:
21.51