SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wz2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 3wz2 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 GLY A  27
GLY A 180
ILE A 153
LEU A 175
ALA A 114
 None
 0.94A 1v2xA-3wz2A:
undetectable		 1v2xA-3wz2A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 3wz2 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 11 GLY A  27
GLY A 180
ILE A 153
LEU A 175
ALA A 114
 None
 0.98A 1x7pA-3wz2A:
2.1
1x7pB-3wz2A:
undetectable		 1x7pA-3wz2A:
21.40
1x7pB-3wz2A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 3wz2 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 10 GLY A  27
GLY A 180
ILE A 153
LEU A 175
ALA A 114
 None
 0.84A 1x7pA-3wz2A:
2.2
1x7pB-3wz2A:
undetectable		 1x7pA-3wz2A:
21.40
1x7pB-3wz2A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 3wz2 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 GLY A 176
GLY A  30
LEU A 113
ASN A 190
ALA A 188
 None
 1.04A 3av6A-3wz2A:
undetectable		 3av6A-3wz2A:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 3wz2 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 11 GLY A  27
GLY A 180
ILE A 153
LEU A 175
ALA A 114
 None
 0.80A 3dcmX-3wz2A:
undetectable		 3dcmX-3wz2A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3wz2 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 8 ILE A  54
PRO A  55
TYR A  23
PRO A  24
 None
 0.94A 3em0B-3wz2A:
undetectable		 3em0B-3wz2A:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_B_DM5B601_1
(SERUM ALBUMIN)		 3wz2 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 9 LEU A   9
VAL A  10
GLU A  97
ILE A  98
TYR A  23
 None
 1.22A 4lb2B-3wz2A:
0.0		 4lb2B-3wz2A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3wz2 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 ALA A 114
GLY A 115
GLY A 176
ASP A 184
GLY A 158
 None
 1.00A 4obwB-3wz2A:
undetectable		 4obwB-3wz2A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3wz2 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 HIS A  31
ASP A  83
LEU A 219
LEU A  28
GLY A  27
 None
 1.44A 4pfjB-3wz2A:
undetectable		 4pfjB-3wz2A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3wz2 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 HIS A  31
ASP A  83
LEU A 219
LEU A  28
GLY A  27
 None
 1.38A 4pgfB-3wz2A:
undetectable		 4pgfB-3wz2A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 3wz2 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 GLY A 131
ILE A 153
GLY A 129
ILE A 130
ILE A 111
 None
 0.89A 4q5mA-3wz2A:
undetectable		 4q5mA-3wz2A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 3wz2 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 11 LEU A 140
LEU A 113
LEU A 174
ILE A 111
LEU A  37
 None
 1.04A 4zowA-3wz2A:
undetectable		 4zowA-3wz2A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 3wz2 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 7 GLY A 132
SER A 133
GLY A 131
VAL A 173
LEU A 140
 None
 1.17A 5izjB-3wz2A:
undetectable		 5izjB-3wz2A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 3wz2 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 GLY A  27
GLY A 180
ILE A 153
LEU A 175
ALA A 114
 None
 0.94A 5l0zA-3wz2A:
2.1		 5l0zA-3wz2A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 3wz2 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 10 GLY A  27
GLY A 180
ILE A 153
LEU A 175
ALA A 114
 None
 0.99A 5l0zB-3wz2A:
undetectable		 5l0zB-3wz2A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_2
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 3wz2 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		3 / 3 VAL A 205
LYS A  39
MET A  43
 None
 0.92A 5nknA-3wz2A:
undetectable		 5nknA-3wz2A:
13.52