SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wz4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 3wz4 DOTI
(Legionella
pneumophila) 		5 / 12 ARG A 159
GLY A 198
SER A 200
PHE A 202
ILE A 197
 MPD  A 504 (-2.7A)
None
None
None
None
 1.42A 1q8jA-3wz4A:
undetectable		 1q8jA-3wz4A:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 3wz4 DOTI
(Legionella
pneumophila) 		4 / 6 ALA A 110
ASP A 114
GLU A 111
ARG A 155
 None
 1.25A 2ouzA-3wz4A:
undetectable		 2ouzA-3wz4A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_A_9PLA501_1
(CYTOCHROME P450 2A6)		 3wz4 DOTI
(Legionella
pneumophila) 		5 / 10 PHE A 202
PHE A 116
PHE A 108
PHE A  90
ALA A  88
 None
None
None
MRD  A 502 (-4.1A)
None
 1.28A 3t3qA-3wz4A:
undetectable		 3t3qA-3wz4A:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 3wz4 DOTI
(Legionella
pneumophila) 		4 / 8 PHE A 202
PHE A 116
PHE A 108
ALA A  88
 None
 0.91A 3t3sD-3wz4A:
undetectable		 3t3sD-3wz4A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 3wz4 DOTI
(Legionella
pneumophila) 		4 / 7 PHE A 202
PHE A 116
PHE A 108
ALA A  88
 None
 0.81A 4ejgC-3wz4A:
undetectable		 4ejgC-3wz4A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3wz4 DOTI
(Legionella
pneumophila) 		4 / 6 ALA A 138
VAL A 136
TYR A 168
VAL A 204
 None
None
MRD  A 501 ( 4.1A)
None
 0.88A 5eclA-3wz4A:
undetectable		 5eclA-3wz4A:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 3wz4 DOTI
(Legionella
pneumophila) 		4 / 7 GLY A 198
PHE A 107
SER A 193
ARG A 159
 None
None
None
MPD  A 504 (-2.7A)
 0.87A 5n5dB-3wz4A:
undetectable		 5n5dB-3wz4A:
18.58