SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wzf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC
(Homo
sapiens) 		4 / 8 GLN A 204
LEU A 177
TYR A 158
LEU A 188
 None
 0.85A 1hk2A-3wzfA:
undetectable		 1hk2A-3wzfA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3002_1
(SERUM ALBUMIN)		 3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC
(Homo
sapiens) 		4 / 8 GLN A 204
LEU A 177
TYR A 158
LEU A 188
 None
 0.86A 1hk3A-3wzfA:
undetectable		 1hk3A-3wzfA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3002_1
(SERUM ALBUMIN)		 3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC
(Homo
sapiens) 		4 / 8 GLN A 207
LEU A 177
TYR A 158
LEU A 188
 None
 1.00A 1hk3A-3wzfA:
undetectable		 1hk3A-3wzfA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC
(Homo
sapiens) 		3 / 3 GLU A 318
LYS A  54
VAL A  52
 None
 0.91A 1l2iA-3wzfA:
undetectable		 1l2iA-3wzfA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 12 TYR A 134
VAL A 211
LEU A 177
LEU A 174
LEU A 168
 None
 1.38A 1mmkA-3wzfA:
undetectable		 1mmkA-3wzfA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 12 LEU A 337
GLY A 197
GLY A 358
ILE A 353
LEU A 373
 None
 1.07A 1p91B-3wzfA:
3.2		 1p91B-3wzfA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 9 ALA A 307
PHE A 256
GLY A 268
SER A  81
ALA A  83
 None
 1.19A 2vh3A-3wzfA:
undetectable		 2vh3A-3wzfA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_P_CHDP1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC
(Homo
sapiens) 		4 / 5 PHE A 250
PHE A 218
LEU A 119
PHE A 118
 None
 1.28A 2y69P-3wzfA:
undetectable
2y69W-3wzfA:
undetectable		 2y69P-3wzfA:
20.62
2y69W-3wzfA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC
(Homo
sapiens) 		3 / 3 ASP A  27
PHE A  24
LEU A  20
 None
 0.65A 2zi9A-3wzfA:
undetectable		 2zi9A-3wzfA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC
(Homo
sapiens) 		4 / 7 ILE A 185
PHE A 243
PHE A 221
GLY A 115
 None
 0.97A 3em0B-3wzfA:
undetectable		 3em0B-3wzfA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 12 LEU A 174
GLY A 172
LEU A 170
ILE A 208
LEU A 188
 None
 0.74A 3gwvA-3wzfA:
undetectable		 3gwvA-3wzfA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA304_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC
(Homo
sapiens) 		4 / 4 GLN A  11
PRO A  10
VAL A   9
GLU A   8
 None
 1.36A 3huoA-3wzfA:
undetectable		 3huoA-3wzfA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_B_EAAB222_1
(GLUTATHIONE
S-TRANSFERASE P)		 3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 9 PHE A 260
VAL A 267
VAL A  53
TRP A 319
GLY A 302
 None
 1.48A 3km6B-3wzfA:
undetectable		 3km6B-3wzfA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC
(Homo
sapiens) 		4 / 5 PHE A 220
ILE A 240
ASN A 142
PHE A 250
 None
 1.39A 3octA-3wzfA:
undetectable		 3octA-3wzfA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 12 ARG A 241
GLN A 226
PHE A 316
GLY A 321
GLY A 227
 None
 1.17A 3tegA-3wzfA:
2.4		 3tegA-3wzfA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 12 ILE A 240
ALA A 190
VAL A 146
ASP A 222
PHE A 220
 None
 1.26A 3vw1D-3wzfA:
undetectable		 3vw1D-3wzfA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC
(Homo
sapiens) 		4 / 6 ILE A 387
LEU A 381
ARG A 340
THR A 402
 None
 1.00A 3wg7A-3wzfA:
undetectable
3wg7J-3wzfA:
undetectable		 3wg7A-3wzfA:
20.90
3wg7J-3wzfA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC
(Homo
sapiens) 		4 / 8 SER A 255
SER A 257
ASN A 259
GLY A 302
 None
 1.00A 4af0A-3wzfA:
undetectable		 4af0A-3wzfA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC
(Homo
sapiens) 		4 / 8 SER A 255
SER A 257
ASN A 259
GLY A 302
 None
 0.93A 4fo4A-3wzfA:
undetectable		 4fo4A-3wzfA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_A_ACTA401_0
(UNCHARACTERIZED
PROTEIN)		 3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 9 GLY A 108
SER A 255
SER A 257
GLY A 107
THR A 109
 None
 1.47A 4lb0A-3wzfA:
undetectable		 4lb0A-3wzfA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC
(Homo
sapiens) 		4 / 8 ALA A 224
SER A 257
ALA A 111
SER A 105
 None
 0.76A 4twdF-3wzfA:
undetectable
4twdG-3wzfA:
undetectable
4twdH-3wzfA:
undetectable
4twdI-3wzfA:
undetectable
4twdJ-3wzfA:
undetectable		 4twdF-3wzfA:
22.28
4twdG-3wzfA:
22.28
4twdH-3wzfA:
22.28
4twdI-3wzfA:
22.28
4twdJ-3wzfA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC
(Homo
sapiens) 		4 / 6 ILE A 387
LEU A 381
ARG A 340
THR A 402
 None
 0.98A 5b1aN-3wzfA:
undetectable
5b1aW-3wzfA:
undetectable		 5b1aN-3wzfA:
20.90
5b1aW-3wzfA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_1
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 12 GLY A 151
PHE A 152
PHE A 218
ASP A 117
PHE A 147
 None
 1.38A 5nknA-3wzfA:
undetectable		 5nknA-3wzfA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC
(Homo
sapiens) 		4 / 8 LEU A 119
TYR A 123
THR A 131
VAL A 186
 None
 1.00A 5ov9B-3wzfA:
2.2		 5ov9B-3wzfA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC
(Homo
sapiens) 		4 / 5 PHE A 250
PHE A 218
LEU A 119
PHE A 118
 None
 1.27A 5xdqC-3wzfA:
undetectable
5xdqJ-3wzfA:
undetectable		 5xdqC-3wzfA:
20.62
5xdqJ-3wzfA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC
(Homo
sapiens) 		4 / 7 ILE A 387
LEU A 381
ARG A 340
THR A 402
 None
 0.91A 5xdqA-3wzfA:
undetectable
5xdqJ-3wzfA:
undetectable		 5xdqA-3wzfA:
20.90
5xdqJ-3wzfA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 12 GLY A 385
GLY A 364
ILE A 387
VAL A 370
LEU A 373
 None
 0.98A 6ectA-3wzfA:
2.1		 6ectA-3wzfA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 12 GLY A 385
GLY A 364
ILE A 387
VAL A 370
LEU A 373
 None
 0.97A 6ecxA-3wzfA:
undetectable		 6ecxA-3wzfA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC
(Homo
sapiens) 		4 / 7 ILE A 155
GLU A 141
HIS A 143
VAL A 135
 None
 1.06A 6j20A-3wzfA:
undetectable		 6j20A-3wzfA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC
(Homo
sapiens) 		4 / 6 ILE A 387
LEU A 381
ARG A 340
THR A 402
 None
 0.79A 6nmfN-3wzfA:
undetectable
6nmfW-3wzfA:
undetectable		 6nmfN-3wzfA:
20.90
6nmfW-3wzfA:
9.27