SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wzs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 3wzs UDP-GLUCOSE-GLYCOPRO
TEIN
GLUCOSYLTRANSFERASE-
LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 8 LEU A 788
LYS A 754
GLU A 757
ALA A 750
 None
 0.93A 1ie4B-3wzsA:
undetectable
1ie4D-3wzsA:
undetectable		 1ie4B-3wzsA:
19.05
1ie4D-3wzsA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 3wzs UDP-GLUCOSE-GLYCOPRO
TEIN
GLUCOSYLTRANSFERASE-
LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 6 LYS A 754
GLU A 757
ALA A 750
VAL A 736
 None
 1.16A 1sn5A-3wzsA:
undetectable		 1sn5A-3wzsA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 3wzs UDP-GLUCOSE-GLYCOPRO
TEIN
GLUCOSYLTRANSFERASE-
LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 7 ILE A 675
GLY A 808
LEU A 703
PHE A 803
 None
None
PQE  A2000 ( 4.8A)
None
 1.03A 2vctD-3wzsA:
2.2		 2vctD-3wzsA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 3wzs UDP-GLUCOSE-GLYCOPRO
TEIN
GLUCOSYLTRANSFERASE-
LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 6 ASP A 711
ASP A 708
ASN A 738
ALA A 799
 None
 0.88A 4mdbA-3wzsA:
undetectable		 4mdbA-3wzsA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3wzs UDP-GLUCOSE-GLYCOPRO
TEIN
GLUCOSYLTRANSFERASE-
LIKE PROTEIN
(Chaetomium
thermophilum) 		6 / 12 ALA A 721
LEU A 788
HIS A 737
ALA A 707
ASP A 708
GLY A 800
 PQE  A2000 ( 4.2A)
None
None
None
None
None
 1.36A 4v04B-3wzsA:
undetectable		 4v04B-3wzsA:
19.68