SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3x05'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3x05 PHOSPHATIDYLINOSITOL
5-PHOSPHATE 4-KINASE
TYPE-2 BETA
(Homo
sapiens) 		5 / 12 GLY A  49
HIS A  52
GLN A 118
PHE A  36
VAL A  45
 None
 1.49A 1qu3A-3x05A:
undetectable		 1qu3A-3x05A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 3x05 PHOSPHATIDYLINOSITOL
5-PHOSPHATE 4-KINASE
TYPE-2 BETA
(Homo
sapiens) 		4 / 8 LEU A 179
LEU A 261
LYS A 258
ASN A 259
 None
 0.95A 2xn3A-3x05A:
undetectable
2xn3B-3x05A:
undetectable		 2xn3A-3x05A:
21.38
2xn3B-3x05A:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 3x05 PHOSPHATIDYLINOSITOL
5-PHOSPHATE 4-KINASE
TYPE-2 BETA
(Homo
sapiens) 		4 / 6 ARG A 224
ILE A 414
LEU A 250
GLU A 246
 None
 1.02A 2ya7A-3x05A:
undetectable		 2ya7A-3x05A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 3x05 PHOSPHATIDYLINOSITOL
5-PHOSPHATE 4-KINASE
TYPE-2 BETA
(Homo
sapiens) 		4 / 6 ARG A 224
ILE A 414
LEU A 250
GLU A 246
 None
 1.01A 2ya7B-3x05A:
undetectable		 2ya7B-3x05A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 3x05 PHOSPHATIDYLINOSITOL
5-PHOSPHATE 4-KINASE
TYPE-2 BETA
(Homo
sapiens) 		4 / 6 ARG A 224
ILE A 414
LEU A 250
GLU A 246
 None
 1.02A 2ya7D-3x05A:
undetectable		 2ya7D-3x05A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 3x05 PHOSPHATIDYLINOSITOL
5-PHOSPHATE 4-KINASE
TYPE-2 BETA
(Homo
sapiens) 		5 / 11 VAL A 200
GLY A 185
ARG A 107
ILE A  54
THR A  53
 None
 1.30A 3bexC-3x05A:
undetectable
3bexD-3x05A:
undetectable		 3bexC-3x05A:
20.51
3bexD-3x05A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 3x05 PHOSPHATIDYLINOSITOL
5-PHOSPHATE 4-KINASE
TYPE-2 BETA
(Homo
sapiens) 		5 / 10 THR A  53
VAL A 200
GLY A 185
ARG A 107
ILE A  54
 None
 1.30A 3bexC-3x05A:
undetectable
3bexD-3x05A:
undetectable		 3bexC-3x05A:
20.51
3bexD-3x05A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 3x05 PHOSPHATIDYLINOSITOL
5-PHOSPHATE 4-KINASE
TYPE-2 BETA
(Homo
sapiens) 		5 / 10 VAL A 200
GLY A 185
ARG A 107
ILE A  54
THR A  53
 None
 1.31A 3bexE-3x05A:
undetectable
3bexF-3x05A:
undetectable		 3bexE-3x05A:
20.51
3bexF-3x05A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 3x05 PHOSPHATIDYLINOSITOL
5-PHOSPHATE 4-KINASE
TYPE-2 BETA
(Homo
sapiens) 		5 / 11 THR A  53
VAL A 200
GLY A 185
ARG A 107
ILE A  54
 None
 1.30A 3bexE-3x05A:
undetectable
3bexF-3x05A:
undetectable		 3bexE-3x05A:
20.51
3bexF-3x05A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 3x05 PHOSPHATIDYLINOSITOL
5-PHOSPHATE 4-KINASE
TYPE-2 BETA
(Homo
sapiens) 		5 / 11 VAL A 200
GLY A 185
ARG A 107
ILE A  54
THR A  53
 None
 1.30A 3bf1A-3x05A:
undetectable
3bf1B-3x05A:
undetectable		 3bf1A-3x05A:
20.51
3bf1B-3x05A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 3x05 PHOSPHATIDYLINOSITOL
5-PHOSPHATE 4-KINASE
TYPE-2 BETA
(Homo
sapiens) 		5 / 11 VAL A 200
GLY A 185
ARG A 107
ILE A  54
THR A  53
 None
 1.30A 3bf1C-3x05A:
undetectable
3bf1D-3x05A:
undetectable		 3bf1C-3x05A:
20.51
3bf1D-3x05A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 3x05 PHOSPHATIDYLINOSITOL
5-PHOSPHATE 4-KINASE
TYPE-2 BETA
(Homo
sapiens) 		5 / 11 VAL A 200
GLY A 185
ARG A 107
ILE A  54
THR A  53
 None
 1.27A 3bf1E-3x05A:
undetectable
3bf1F-3x05A:
undetectable		 3bf1E-3x05A:
20.51
3bf1F-3x05A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 3x05 PHOSPHATIDYLINOSITOL
5-PHOSPHATE 4-KINASE
TYPE-2 BETA
(Homo
sapiens) 		5 / 11 THR A  53
VAL A 200
GLY A 185
ARG A 107
ILE A  54
 None
 1.30A 3bf1E-3x05A:
undetectable
3bf1F-3x05A:
undetectable		 3bf1E-3x05A:
20.51
3bf1F-3x05A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 3x05 PHOSPHATIDYLINOSITOL
5-PHOSPHATE 4-KINASE
TYPE-2 BETA
(Homo
sapiens) 		3 / 3 THR A 221
SER A 220
ARG A 406
 None
 0.52A 3phnA-3x05A:
undetectable		 3phnA-3x05A:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 3x05 PHOSPHATIDYLINOSITOL
5-PHOSPHATE 4-KINASE
TYPE-2 BETA
(Homo
sapiens) 		3 / 3 LEU A 164
HIS A 161
MET A 160
 None
AMP  A 502 (-3.4A)
None
 0.88A 3thrD-3x05A:
undetectable		 3thrD-3x05A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 3x05 PHOSPHATIDYLINOSITOL
5-PHOSPHATE 4-KINASE
TYPE-2 BETA
(Homo
sapiens) 		3 / 3 THR A 178
ASN A 203
PHE A 205
 None
AMP  A 501 (-3.2A)
AMP  A 501 ( 4.0A)
 0.84A 4pd9A-3x05A:
undetectable		 4pd9A-3x05A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 3x05 PHOSPHATIDYLINOSITOL
5-PHOSPHATE 4-KINASE
TYPE-2 BETA
(Homo
sapiens) 		3 / 3 TYR A  98
ARG A 188
LYS A  96
 AMP  A 502 (-4.4A)
AMP  A 502 (-4.2A)
AMP  A 502 (-2.7A)
 1.48A 4wq5B-3x05A:
undetectable		 4wq5B-3x05A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3x05 PHOSPHATIDYLINOSITOL
5-PHOSPHATE 4-KINASE
TYPE-2 BETA
(Homo
sapiens) 		4 / 5 GLN A 182
PRO A 181
ILE A 367
ASP A 267
 None
 1.25A 4z4hA-3x05A:
undetectable		 4z4hA-3x05A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 3x05 PHOSPHATIDYLINOSITOL
5-PHOSPHATE 4-KINASE
TYPE-2 BETA
(Homo
sapiens) 		5 / 11 ARG A 146
PHE A 147
ILE A  54
ASP A 114
VAL A 346
 None
 1.39A 5jkwA-3x05A:
undetectable		 5jkwA-3x05A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 3x05 PHOSPHATIDYLINOSITOL
5-PHOSPHATE 4-KINASE
TYPE-2 BETA
(Homo
sapiens) 		4 / 6 PHE A  95
GLY A  49
THR A  53
TYR A 117
 None
 0.92A 6ag0A-3x05A:
undetectable		 6ag0A-3x05A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 3x05 PHOSPHATIDYLINOSITOL
5-PHOSPHATE 4-KINASE
TYPE-2 BETA
(Homo
sapiens) 		4 / 6 PHE A  95
GLY A  49
THR A  53
TYR A 117
 None
 0.95A 6ag0C-3x05A:
undetectable		 6ag0C-3x05A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 3x05 PHOSPHATIDYLINOSITOL
5-PHOSPHATE 4-KINASE
TYPE-2 BETA
(Homo
sapiens) 		3 / 3 TRP A  48
ILE A  77
GLU A  97
 None
 0.80A 6hcxA-3x05A:
undetectable		 6hcxA-3x05A:
11.91