SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3x0f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)		 3x0f CD81 ANTIGEN
(Mus
musculus) 		3 / 3 GLN A 133
LYS A 144
VAL A 146
 None
 0.89A 2jfaB-3x0fA:
undetectable		 2jfaB-3x0fA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3x0f CD81 ANTIGEN
(Mus
musculus) 		5 / 12 LEU A 154
GLN A 188
ALA A 120
PHE A 198
SER A 199
 None
 1.44A 3apwB-3x0fA:
undetectable		 3apwB-3x0fA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 3x0f CD81 ANTIGEN
(Mus
musculus) 		5 / 12 THR A 167
THR A 168
HIS A 151
LEU A 131
TYR A 127
 IPA  A 303 ( 4.1A)
None
None
IPA  A 303 ( 3.7A)
None
 1.45A 3gwxB-3x0fA:
undetectable		 3gwxB-3x0fA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N16_A_CHDA301_0
(CARBONIC ANHYDRASE 2)		 3x0f CD81 ANTIGEN
(Mus
musculus) 		4 / 8 GLN A 187
HIS A 151
THR A 167
THR A 168
 None
None
IPA  A 303 ( 4.1A)
None
 0.91A 4n16A-3x0fA:
undetectable		 4n16A-3x0fA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3x0f CD81 ANTIGEN
(Mus
musculus) 		4 / 7 LEU A 185
THR A 168
THR A 164
LEU A 165
 None
None
None
IPA  A 301 ( 3.4A)
 0.92A 4z91F-3x0fA:
undetectable
4z91G-3x0fA:
undetectable
4z91H-3x0fA:
undetectable
4z91I-3x0fA:
undetectable
4z91J-3x0fA:
undetectable		 4z91F-3x0fA:
13.64
4z91G-3x0fA:
13.64
4z91H-3x0fA:
13.64
4z91I-3x0fA:
13.64
4z91J-3x0fA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 3x0f CD81 ANTIGEN
(Mus
musculus) 		4 / 5 VAL A 147
LEU A 131
HIS A 191
THR A 167
 None
IPA  A 303 ( 3.7A)
None
IPA  A 303 ( 4.1A)
 1.50A 6dyoA-3x0fA:
undetectable		 6dyoA-3x0fA:
16.48