SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3x0u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3x0u UNCHARACTERIZED
PROTEIN
(Vibrio
parahaemolyticus) 		5 / 12 LEU A 399
VAL A 365
PHE A 422
VAL A 424
VAL A 388
 None
 1.23A 1q23H-3x0uA:
undetectable
1q23I-3x0uA:
undetectable		 1q23H-3x0uA:
20.67
1q23I-3x0uA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 3x0u UNCHARACTERIZED
PROTEIN
(Vibrio
parahaemolyticus) 		3 / 3 ASP A 187
LYS A 192
ARG A 195
 None
 1.05A 1ra8A-3x0uA:
undetectable		 1ra8A-3x0uA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 3x0u UNCHARACTERIZED
PROTEIN
(Vibrio
parahaemolyticus) 		4 / 7 PHE A 185
GLY A 131
THR A 134
ASP A 189
 None
 0.89A 2a1mA-3x0uA:
undetectable		 2a1mA-3x0uA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3x0u UNCHARACTERIZED
PROTEIN
(Vibrio
parahaemolyticus) 		5 / 12 ILE A 353
ASP A 382
PHE A 380
ILE A 406
ILE A 311
 None
 1.10A 2bl9A-3x0uA:
undetectable		 2bl9A-3x0uA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3x0u UNCHARACTERIZED
PROTEIN
(Vibrio
parahaemolyticus) 		5 / 11 ILE A 353
ASP A 382
PHE A 380
ILE A 406
ILE A 311
 None
 1.12A 2blaA-3x0uA:
undetectable		 2blaA-3x0uA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3x0u UNCHARACTERIZED
PROTEIN
(Vibrio
parahaemolyticus) 		5 / 12 TYR A 220
CYH A 239
ASP A 218
ALA A 215
ALA A 212
 None
 1.09A 2br4B-3x0uA:
undetectable		 2br4B-3x0uA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3x0u UNCHARACTERIZED
PROTEIN
(Vibrio
parahaemolyticus) 		5 / 12 TYR A 220
CYH A 239
ASP A 218
ALA A 215
ALA A 212
 None
 1.15A 2br4C-3x0uA:
undetectable		 2br4C-3x0uA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 3x0u UNCHARACTERIZED
PROTEIN
(Vibrio
parahaemolyticus) 		5 / 12 ASN A  18
TYR A  24
LEU A 162
TYR A 207
ALA A 215
 None
 1.20A 2iyfB-3x0uA:
undetectable		 2iyfB-3x0uA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3x0u UNCHARACTERIZED
PROTEIN
(Vibrio
parahaemolyticus) 		4 / 8 MET A 409
LEU A 330
VAL A 325
GLY A 326
 None
 0.84A 2po5B-3x0uA:
undetectable		 2po5B-3x0uA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 3x0u UNCHARACTERIZED
PROTEIN
(Vibrio
parahaemolyticus) 		4 / 5 LEU A 355
ASP A 382
ALA A 358
ILE A 353
 None
 1.05A 2qhfA-3x0uA:
undetectable		 2qhfA-3x0uA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_A_DMOA700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		 3x0u UNCHARACTERIZED
PROTEIN
(Vibrio
parahaemolyticus) 		4 / 6 TYR A 129
PHE A 183
ASP A 178
TYR A 179
 None
 1.47A 2todA-3x0uA:
undetectable
2todB-3x0uA:
undetectable		 2todA-3x0uA:
23.71
2todB-3x0uA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 3x0u UNCHARACTERIZED
PROTEIN
(Vibrio
parahaemolyticus) 		4 / 8 ILE A 308
PHE A 378
LEU A 340
LEU A 328
 None
 0.91A 2w98B-3x0uA:
undetectable		 2w98B-3x0uA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3x0u UNCHARACTERIZED
PROTEIN
(Vibrio
parahaemolyticus) 		5 / 12 ILE A 311
ILE A 406
LEU A 355
VAL A 388
LEU A 340
 None
 0.99A 3dzuA-3x0uA:
undetectable		 3dzuA-3x0uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3x0u UNCHARACTERIZED
PROTEIN
(Vibrio
parahaemolyticus) 		5 / 12 ILE A 311
LEU A 355
VAL A 388
ILE A 376
LEU A 340
 None
 0.80A 3oapA-3x0uA:
undetectable		 3oapA-3x0uA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3x0u UNCHARACTERIZED
PROTEIN
(Vibrio
parahaemolyticus) 		5 / 10 ILE A 353
ASP A 382
PHE A 380
ILE A 406
ILE A 311
 None
 1.11A 3um5A-3x0uA:
undetectable		 3um5A-3x0uA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3x0u UNCHARACTERIZED
PROTEIN
(Vibrio
parahaemolyticus) 		5 / 10 ILE A 353
ASP A 382
PHE A 380
ILE A 406
ILE A 311
 None
 1.16A 3um5B-3x0uA:
undetectable		 3um5B-3x0uA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3x0u UNCHARACTERIZED
PROTEIN
(Vibrio
parahaemolyticus) 		4 / 4 PRO A 160
LEU A 161
ILE A  95
ARG A  80
 None
 1.40A 3w1wA-3x0uA:
undetectable		 3w1wA-3x0uA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_B_ACTB1114_0
(BLR5658 PROTEIN)		 3x0u UNCHARACTERIZED
PROTEIN
(Vibrio
parahaemolyticus) 		3 / 3 TRP A  63
TRP A  76
THR A 164
 None
 1.50A 4bboB-3x0uA:
undetectable		 4bboB-3x0uA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 3x0u UNCHARACTERIZED
PROTEIN
(Vibrio
parahaemolyticus) 		4 / 8 ARG A 327
GLU A 339
GLU A 312
LYS A 310
 None
 1.12A 4bqfB-3x0uA:
undetectable		 4bqfB-3x0uA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 3x0u UNCHARACTERIZED
PROTEIN
(Vibrio
parahaemolyticus) 		4 / 8 ASN A 217
CYH A 239
MET A 233
GLY A 234
 None
 0.81A 4fo4A-3x0uA:
undetectable		 4fo4A-3x0uA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 3x0u UNCHARACTERIZED
PROTEIN
(Vibrio
parahaemolyticus) 		3 / 3 TRP A  59
GLN A 169
THR A 106
 None
 1.00A 4m2xA-3x0uA:
undetectable		 4m2xA-3x0uA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3x0u UNCHARACTERIZED
PROTEIN
(Vibrio
parahaemolyticus) 		4 / 6 PHE A 378
MET A 409
ILE A 311
VAL A 325
 None
 1.35A 4mk4B-3x0uA:
undetectable		 4mk4B-3x0uA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_A_ACTA202_0
(NITROGEN REGULATORY
PROTEIN P-II)		 3x0u UNCHARACTERIZED
PROTEIN
(Vibrio
parahaemolyticus) 		4 / 4 VAL A 388
GLY A 389
ARG A 375
VAL A 377
 None
 1.46A 5d4nA-3x0uA:
undetectable
5d4nB-3x0uA:
undetectable		 5d4nA-3x0uA:
13.30
5d4nB-3x0uA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3x0u UNCHARACTERIZED
PROTEIN
(Vibrio
parahaemolyticus) 		5 / 12 ASP A 230
ALA A 425
GLY A 275
PHE A 422
VAL A 365
 None
 1.00A 5i73A-3x0uA:
2.3		 5i73A-3x0uA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 3x0u UNCHARACTERIZED
PROTEIN
(Vibrio
parahaemolyticus) 		4 / 8 ASP A 432
PRO A 431
SER A  46
ASN A  47
 None
 0.98A 5l1fA-3x0uA:
2.3
5l1fB-3x0uA:
undetectable		 5l1fA-3x0uA:
20.25
5l1fB-3x0uA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 3x0u UNCHARACTERIZED
PROTEIN
(Vibrio
parahaemolyticus) 		3 / 3 SER A 271
TYR A 270
TYR A 426
 None
 0.90A 5lakA-3x0uA:
undetectable
5lakI-3x0uA:
undetectable		 5lakA-3x0uA:
21.13
5lakI-3x0uA:
1.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 3x0u UNCHARACTERIZED
PROTEIN
(Vibrio
parahaemolyticus) 		3 / 3 SER A 271
TYR A 270
TYR A 426
 None
 0.87A 5lakC-3x0uA:
undetectable
5lakJ-3x0uA:
undetectable		 5lakC-3x0uA:
21.13
5lakJ-3x0uA:
1.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 3x0u UNCHARACTERIZED
PROTEIN
(Vibrio
parahaemolyticus) 		5 / 12 TRP A  63
ILE A  75
PHE A  37
TYR A 172
TRP A  76
 None
 1.21A 5nz0A-3x0uA:
2.0		 5nz0A-3x0uA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 3x0u UNCHARACTERIZED
PROTEIN
(Vibrio
parahaemolyticus) 		5 / 10 ASN A  18
LEU A 154
ASP A 149
LEU A  12
GLY A 150
 None
 1.42A 6r2eB-3x0uA:
undetectable		 6r2eB-3x0uA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 3x0u UNCHARACTERIZED
PROTEIN
(Vibrio
parahaemolyticus) 		5 / 10 ASN A  18
LEU A 154
ASP A 149
LEU A  12
GLY A 150
 None
 1.41A 6r2eD-3x0uA:
undetectable		 6r2eD-3x0uA:
21.68