SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3x1d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3x1d ATLASTIN
(Drosophila
melanogaster) 		4 / 7 PHE A 189
SER A 146
PHE A 168
LEU A 228
 None
 1.00A 1qcaA-3x1dA:
undetectable		 1qcaA-3x1dA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3x1d ATLASTIN
(Drosophila
melanogaster) 		4 / 7 LEU A 167
PHE A 236
VAL A 148
SER A 146
 None
 1.06A 1wrlA-3x1dA:
undetectable
1wrlB-3x1dA:
undetectable		 1wrlA-3x1dA:
9.76
1wrlB-3x1dA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)		 3x1d ATLASTIN
(Drosophila
melanogaster) 		3 / 3 CYH A 235
PHE A 184
PHE A 236
 None
 0.76A 3cr5X-3x1dA:
undetectable		 3cr5X-3x1dA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3x1d ATLASTIN
(Drosophila
melanogaster) 		5 / 10 PHE A 189
TYR A 151
PHE A 139
PHE A 168
LEU A 228
 None
 1.37A 3u9fR-3x1dA:
undetectable		 3u9fR-3x1dA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 3x1d ATLASTIN
(Drosophila
melanogaster) 		3 / 3 ARG A 229
GLN A 226
GLU A 159
 None
 0.81A 4tvtA-3x1dA:
undetectable		 4tvtA-3x1dA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 3x1d ATLASTIN
(Drosophila
melanogaster) 		5 / 12 ILE A 232
LEU A 228
LEU A 153
ILE A 157
LEU A 187
 None
 1.17A 5ienA-3x1dA:
undetectable		 5ienA-3x1dA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 3x1d ATLASTIN
(Drosophila
melanogaster) 		3 / 3 VAL A 286
TYR A 287
GLU A 238
 None
 0.98A 5zmqD-3x1dA:
undetectable
5zmqE-3x1dA:
undetectable		 5zmqD-3x1dA:
15.96
5zmqE-3x1dA:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 3x1d ATLASTIN
(Drosophila
melanogaster) 		3 / 3 LEU A 275
LEU A  54
ARG A 192
 None
None
GDP  A 601 (-4.4A)
 0.70A 6fgcA-3x1dA:
2.6		 6fgcA-3x1dA:
22.03