SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3x1o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 3x1o ROQUIN-1
(Homo
sapiens) 		4 / 4 ARG A 251
ALA A 189
ALA A 294
GLU A 293
 None
 1.22A 1e7bB-3x1oA:
undetectable		 1e7bB-3x1oA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)		 3x1o ROQUIN-1
(Homo
sapiens) 		4 / 5 ARG A 251
ALA A 189
ALA A 294
GLU A 293
 None
 1.23A 1e7cA-3x1oA:
undetectable		 1e7cA-3x1oA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 3x1o ROQUIN-1
(Homo
sapiens) 		3 / 3 PHE A 194
TYR A 308
PRO A 197
 None
 1.18A 1mcnA-3x1oA:
undetectable
1mcnB-3x1oA:
undetectable
1mcnP-3x1oA:
undetectable		 1mcnA-3x1oA:
23.01
1mcnB-3x1oA:
23.01
1mcnP-3x1oA:
0.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3x1o ROQUIN-1
(Homo
sapiens) 		4 / 6 ALA A 252
LEU A 204
GLU A 282
LEU A 307
 None
 0.90A 1mt1D-3x1oA:
undetectable
1mt1E-3x1oA:
undetectable		 1mt1D-3x1oA:
18.84
1mt1E-3x1oA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_B_P1ZB2001_1
(SERUM ALBUMIN)		 3x1o ROQUIN-1
(Homo
sapiens) 		5 / 9 GLU A 293
LEU A 179
LEU A 183
ARG A 190
ALA A 294
 None
 1.50A 2bxcB-3x1oA:
2.4		 2bxcB-3x1oA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 3x1o ROQUIN-1
(Homo
sapiens) 		5 / 12 LEU A 307
LEU A 249
VAL A 245
LEU A 204
ARG A 280
 None
 1.34A 2bxfB-3x1oA:
undetectable		 2bxfB-3x1oA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 3x1o ROQUIN-1
(Homo
sapiens) 		3 / 3 ARG A 280
GLU A 201
GLN A 200
 None
 1.09A 2p16A-3x1oA:
undetectable		 2p16A-3x1oA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 3x1o ROQUIN-1
(Homo
sapiens) 		3 / 3 LYS A 239
LYS A 220
VAL A 223
 None
 1.09A 3brfA-3x1oA:
undetectable		 3brfA-3x1oA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 3x1o ROQUIN-1
(Homo
sapiens) 		3 / 3 ARG A 251
GLN A 289
GLU A 293
 None
 0.87A 4tvtA-3x1oA:
undetectable		 4tvtA-3x1oA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 3x1o ROQUIN-1
(Homo
sapiens) 		5 / 12 LEU A 204
TYR A 276
LEU A 324
ILE A 320
HIS A 316
 None
 1.14A 5dv4A-3x1oA:
undetectable		 5dv4A-3x1oA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 3x1o ROQUIN-1
(Homo
sapiens) 		4 / 6 TRP A 184
GLY A 295
ALA A 186
LEU A 183
 None
 0.97A 6fosA-3x1oA:
undetectable		 6fosA-3x1oA:
17.58