SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3x27'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 3x27 CUCUMOPINE SYNTHASE
(Marinactinospora
thermotolerans) 		3 / 3 ASP A  77
THR A  79
GLU A  70
 None
 0.87A 1pj7A-3x27A:
undetectable		 1pj7A-3x27A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 3x27 CUCUMOPINE SYNTHASE
(Marinactinospora
thermotolerans) 		5 / 12 LEU A  88
LEU A  52
ALA A 121
ALA A 118
VAL A  90
 None
 1.21A 1rbpA-3x27A:
undetectable		 1rbpA-3x27A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 3x27 CUCUMOPINE SYNTHASE
(Marinactinospora
thermotolerans) 		4 / 6 LEU A  31
LEU A  35
ILE A   4
ARG A 139
 None
 1.07A 2rlfB-3x27A:
undetectable
2rlfC-3x27A:
undetectable		 2rlfB-3x27A:
7.49
2rlfC-3x27A:
7.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3x27 CUCUMOPINE SYNTHASE
(Marinactinospora
thermotolerans) 		4 / 5 GLN A 168
THR A 171
THR A 263
LEU A 219
 None
 1.40A 2zj0A-3x27A:
undetectable		 2zj0A-3x27A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 3x27 CUCUMOPINE SYNTHASE
(Marinactinospora
thermotolerans) 		4 / 6 TYR A 289
ALA A 290
LEU A 293
THR A 254
 None
 0.71A 3b6hA-3x27A:
undetectable		 3b6hA-3x27A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 3x27 CUCUMOPINE SYNTHASE
(Marinactinospora
thermotolerans) 		4 / 6 TYR A 289
ALA A 290
LEU A 293
THR A 254
 None
 0.83A 3b6hB-3x27A:
undetectable		 3b6hB-3x27A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3x27 CUCUMOPINE SYNTHASE
(Marinactinospora
thermotolerans) 		5 / 11 ALA A 248
LEU A 259
LEU A 288
ILE A 167
GLY A 215
 None
 1.05A 3zosA-3x27A:
undetectable
3zosB-3x27A:
undetectable		 3zosA-3x27A:
23.18
3zosB-3x27A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3x27 CUCUMOPINE SYNTHASE
(Marinactinospora
thermotolerans) 		4 / 8 VAL A 137
HIS A  54
LEU A  61
LEU A  82
 None
 1.05A 4jtrA-3x27A:
undetectable		 4jtrA-3x27A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 3x27 CUCUMOPINE SYNTHASE
(Marinactinospora
thermotolerans) 		4 / 5 GLN A 168
THR A 171
THR A 263
LEU A 219
 None
 1.31A 4lvcA-3x27A:
undetectable		 4lvcA-3x27A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 3x27 CUCUMOPINE SYNTHASE
(Marinactinospora
thermotolerans) 		4 / 5 GLN A 168
THR A 171
THR A 263
LEU A 219
 None
 1.32A 4lvcC-3x27A:
undetectable		 4lvcC-3x27A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 3x27 CUCUMOPINE SYNTHASE
(Marinactinospora
thermotolerans) 		5 / 10 LEU A 288
GLY A 215
ILE A  56
LEU A  61
LEU A  85
 None
 1.05A 5l0zB-3x27A:
undetectable		 5l0zB-3x27A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3x27 CUCUMOPINE SYNTHASE
(Marinactinospora
thermotolerans) 		4 / 4 GLN A 168
THR A 171
THR A 263
LEU A 219
 None
 1.32A 5m5kA-3x27A:
undetectable		 5m5kA-3x27A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3x27 CUCUMOPINE SYNTHASE
(Marinactinospora
thermotolerans) 		4 / 4 GLN A 168
THR A 171
THR A 263
LEU A 219
 None
 1.28A 5m66B-3x27A:
undetectable		 5m66B-3x27A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 3x27 CUCUMOPINE SYNTHASE
(Marinactinospora
thermotolerans) 		4 / 7 ARG A 151
THR A 152
PRO A 153
PRO A  59
 None
 1.39A 6a4iB-3x27A:
2.4		 6a4iB-3x27A:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_B_ADNB502_2
(-)		 3x27 CUCUMOPINE SYNTHASE
(Marinactinospora
thermotolerans) 		4 / 4 GLN A 168
THR A 171
THR A 263
LEU A 219
 None
 1.27A 6f3mB-3x27A:
undetectable		 6f3mB-3x27A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 3x27 CUCUMOPINE SYNTHASE
(Marinactinospora
thermotolerans) 		4 / 5 GLN A 168
THR A 171
THR A 263
LEU A 219
 None
 1.31A 6gbnA-3x27A:
undetectable		 6gbnA-3x27A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)		 3x27 CUCUMOPINE SYNTHASE
(Marinactinospora
thermotolerans) 		4 / 5 GLN A 168
THR A 171
THR A 263
LEU A 219
 None
 1.33A 6gbnD-3x27A:
undetectable		 6gbnD-3x27A:
20.49