SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3x2z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 3x2z UPF0173
METAL-DEPENDENT
HYDROLASE TM_1162
(Thermotoga
maritima) 		5 / 11 ASP A  52
HIS A  53
HIS A 108
ASP A 141
HIS A 190
 NI  A 302 (-2.7A)
NI  A 302 (-3.6A)
NI  A 301 (-3.4A)
NI  A 302 ( 2.5A)
NI  A 302 (-3.6A)
 0.69A 2q0jB-3x2zA:
10.3		 2q0jB-3x2zA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 3x2z UPF0173
METAL-DEPENDENT
HYDROLASE TM_1162
(Thermotoga
maritima) 		3 / 3 LEU A 161
PRO A 162
ARG A 176
 None
 0.58A 2qd4B-3x2zA:
undetectable		 2qd4B-3x2zA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3x2z UPF0173
METAL-DEPENDENT
HYDROLASE TM_1162
(Thermotoga
maritima) 		5 / 9 ALA A 199
ILE A 197
GLY A 164
ILE A 163
HIS A   8
 None
 1.25A 2zm9A-3x2zA:
undetectable		 2zm9A-3x2zA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		 3x2z UPF0173
METAL-DEPENDENT
HYDROLASE TM_1162
(Thermotoga
maritima) 		5 / 8 HIS A  53
HIS A  48
ASP A  52
HIS A  50
GLY A  51
 NI  A 302 (-3.6A)
NI  A 301 (-3.5A)
NI  A 302 (-2.7A)
NI  A 301 (-3.3A)
None
 1.40A 3c0zB-3x2zA:
undetectable		 3c0zB-3x2zA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_2
(TYROSINE-PROTEIN
KINASE ABL2)		 3x2z UPF0173
METAL-DEPENDENT
HYDROLASE TM_1162
(Thermotoga
maritima) 		4 / 5 LYS A  40
VAL A  68
ILE A  41
MET A   1
 None
 1.47A 3gvuA-3x2zA:
undetectable		 3gvuA-3x2zA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3x2z UPF0173
METAL-DEPENDENT
HYDROLASE TM_1162
(Thermotoga
maritima) 		5 / 12 HIS A 138
HIS A  50
LEU A 113
GLY A 111
ASP A 141
 None
NI  A 301 (-3.3A)
None
None
NI  A 302 ( 2.5A)
 0.98A 4blvB-3x2zA:
undetectable		 4blvB-3x2zA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_A_SHHA700_1
(HISTONE DEACETYLASE
8)		 3x2z UPF0173
METAL-DEPENDENT
HYDROLASE TM_1162
(Thermotoga
maritima) 		5 / 10 HIS A  53
HIS A  48
ASP A  52
HIS A  50
GLY A  51
 NI  A 302 (-3.6A)
NI  A 301 (-3.5A)
NI  A 302 (-2.7A)
NI  A 301 (-3.3A)
None
 1.44A 4bz6A-3x2zA:
undetectable		 4bz6A-3x2zA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 3x2z UPF0173
METAL-DEPENDENT
HYDROLASE TM_1162
(Thermotoga
maritima) 		5 / 12 HIS A  53
HIS A  48
ASP A  52
HIS A  50
GLY A  51
 NI  A 302 (-3.6A)
NI  A 301 (-3.5A)
NI  A 302 (-2.7A)
NI  A 301 (-3.3A)
None
 1.45A 4bz6A-3x2zA:
undetectable
4bz6B-3x2zA:
undetectable		 4bz6A-3x2zA:
18.00
4bz6B-3x2zA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_D_SHHD700_1
(HISTONE DEACETYLASE
8)		 3x2z UPF0173
METAL-DEPENDENT
HYDROLASE TM_1162
(Thermotoga
maritima) 		5 / 10 HIS A  53
HIS A  48
ASP A  52
HIS A  50
GLY A  51
 NI  A 302 (-3.6A)
NI  A 301 (-3.5A)
NI  A 302 (-2.7A)
NI  A 301 (-3.3A)
None
 1.44A 4bz6D-3x2zA:
undetectable		 4bz6D-3x2zA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 3x2z UPF0173
METAL-DEPENDENT
HYDROLASE TM_1162
(Thermotoga
maritima) 		5 / 10 HIS A  48
HIS A  50
ASP A  52
HIS A 108
HIS A 190
 NI  A 301 (-3.5A)
NI  A 301 (-3.3A)
NI  A 302 (-2.7A)
NI  A 301 (-3.4A)
NI  A 302 (-3.6A)
 0.77A 4c1dB-3x2zA:
3.4		 4c1dB-3x2zA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 3x2z UPF0173
METAL-DEPENDENT
HYDROLASE TM_1162
(Thermotoga
maritima) 		5 / 11 HIS A  48
HIS A  50
ASP A  52
HIS A 108
HIS A 190
 NI  A 301 (-3.5A)
NI  A 301 (-3.3A)
NI  A 302 (-2.7A)
NI  A 301 (-3.4A)
NI  A 302 (-3.6A)
 0.80A 4c1fA-3x2zA:
10.0
4c1fB-3x2zA:
9.8		 4c1fA-3x2zA:
23.90
4c1fB-3x2zA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 3x2z UPF0173
METAL-DEPENDENT
HYDROLASE TM_1162
(Thermotoga
maritima) 		5 / 9 HIS A  48
HIS A  50
ASP A  52
HIS A 108
HIS A 190
 NI  A 301 (-3.5A)
NI  A 301 (-3.3A)
NI  A 302 (-2.7A)
NI  A 301 (-3.4A)
NI  A 302 (-3.6A)
 0.80A 4c1hA-3x2zA:
9.7		 4c1hA-3x2zA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 3x2z UPF0173
METAL-DEPENDENT
HYDROLASE TM_1162
(Thermotoga
maritima) 		4 / 8 HIS A  50
ASP A  52
HIS A 108
HIS A 190
 NI  A 301 (-3.3A)
NI  A 302 (-2.7A)
NI  A 301 (-3.4A)
NI  A 302 (-3.6A)
 0.76A 4exsB-3x2zA:
9.2		 4exsB-3x2zA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		 3x2z UPF0173
METAL-DEPENDENT
HYDROLASE TM_1162
(Thermotoga
maritima) 		5 / 11 HIS A  53
HIS A  48
ASP A  52
HIS A  50
GLY A  51
 NI  A 302 (-3.6A)
NI  A 301 (-3.5A)
NI  A 302 (-2.7A)
NI  A 301 (-3.3A)
None
 1.43A 4lxzB-3x2zA:
undetectable		 4lxzB-3x2zA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 3x2z UPF0173
METAL-DEPENDENT
HYDROLASE TM_1162
(Thermotoga
maritima) 		4 / 8 HIS A  50
ASP A  52
HIS A 108
HIS A 190
 NI  A 301 (-3.3A)
NI  A 302 (-2.7A)
NI  A 301 (-3.4A)
NI  A 302 (-3.6A)
 0.76A 5a5zA-3x2zA:
9.1		 5a5zA-3x2zA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 3x2z UPF0173
METAL-DEPENDENT
HYDROLASE TM_1162
(Thermotoga
maritima) 		6 / 11 HIS A  48
HIS A  50
ASP A  52
HIS A  53
HIS A 108
HIS A 190
 NI  A 301 (-3.5A)
NI  A 301 (-3.3A)
NI  A 302 (-2.7A)
NI  A 302 (-3.6A)
NI  A 301 (-3.4A)
NI  A 302 (-3.6A)
 0.38A 5ayaA-3x2zA:
10.9		 5ayaA-3x2zA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3x2z UPF0173
METAL-DEPENDENT
HYDROLASE TM_1162
(Thermotoga
maritima) 		4 / 7 ALA A 177
ASP A 141
GLY A 165
THR A 193
 None
NI  A 302 ( 2.5A)
None
None
 1.01A 5btdA-3x2zA:
undetectable
5btdB-3x2zA:
undetectable
5btdC-3x2zA:
undetectable		 5btdA-3x2zA:
18.84
5btdB-3x2zA:
21.69
5btdC-3x2zA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3x2z UPF0173
METAL-DEPENDENT
HYDROLASE TM_1162
(Thermotoga
maritima) 		4 / 7 ALA A 177
ASP A 141
GLY A 165
THR A 193
 None
NI  A 302 ( 2.5A)
None
None
 1.01A 5btdA-3x2zA:
undetectable
5btdC-3x2zA:
undetectable
5btdD-3x2zA:
undetectable		 5btdA-3x2zA:
18.84
5btdC-3x2zA:
18.84
5btdD-3x2zA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3x2z UPF0173
METAL-DEPENDENT
HYDROLASE TM_1162
(Thermotoga
maritima) 		5 / 12 ILE A 136
PHE A  98
ILE A  69
LEU A  45
ILE A  19
 None
 0.99A 5mueA-3x2zA:
undetectable		 5mueA-3x2zA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 3x2z UPF0173
METAL-DEPENDENT
HYDROLASE TM_1162
(Thermotoga
maritima) 		4 / 8 PHE A  96
MET A  88
LEU A  45
ILE A  19
 None
 0.86A 5mzjA-3x2zA:
undetectable		 5mzjA-3x2zA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3x2z UPF0173
METAL-DEPENDENT
HYDROLASE TM_1162
(Thermotoga
maritima) 		5 / 10 HIS A  48
HIS A  50
HIS A  53
HIS A 108
ASP A 141
 NI  A 301 (-3.5A)
NI  A 301 (-3.3A)
NI  A 302 (-3.6A)
NI  A 301 (-3.4A)
NI  A 302 ( 2.5A)
 0.35A 5nzwA-3x2zA:
8.9		 5nzwA-3x2zA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3x2z UPF0173
METAL-DEPENDENT
HYDROLASE TM_1162
(Thermotoga
maritima) 		5 / 10 HIS A  53
HIS A 190
HIS A  48
ASP A 141
HIS A 108
 NI  A 302 (-3.6A)
NI  A 302 (-3.6A)
NI  A 301 (-3.5A)
NI  A 302 ( 2.5A)
NI  A 301 (-3.4A)
 1.08A 5nzwA-3x2zA:
8.9		 5nzwA-3x2zA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 3x2z UPF0173
METAL-DEPENDENT
HYDROLASE TM_1162
(Thermotoga
maritima) 		5 / 12 LEU A 224
PHE A   5
VAL A 216
THR A  47
GLY A 126
 None
 1.21A 5xiqA-3x2zA:
undetectable		 5xiqA-3x2zA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 3x2z UPF0173
METAL-DEPENDENT
HYDROLASE TM_1162
(Thermotoga
maritima) 		5 / 12 LEU A 224
PHE A   5
VAL A 216
THR A  47
GLY A 126
 None
 1.17A 5xiqD-3x2zA:
undetectable		 5xiqD-3x2zA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 3x2z UPF0173
METAL-DEPENDENT
HYDROLASE TM_1162
(Thermotoga
maritima) 		5 / 11 GLU A 202
GLY A 164
ASP A 170
ALA A 199
PRO A 188
 None
 1.19A 5yk2A-3x2zA:
undetectable		 5yk2A-3x2zA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 3x2z UPF0173
METAL-DEPENDENT
HYDROLASE TM_1162
(Thermotoga
maritima) 		4 / 8 HIS A  50
ASP A  52
HIS A 108
HIS A 190
 NI  A 301 (-3.3A)
NI  A 302 (-2.7A)
NI  A 301 (-3.4A)
NI  A 302 (-3.6A)
 0.81A 5zj8A-3x2zA:
3.2		 5zj8A-3x2zA:
20.88