SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3x43'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae)
5 / 12 VAL A 198
ALA A 200
LEU A 209
LEU A 231
THR A 174
None
1.14A 1qzfA-3x43A:
2.4
1qzfA-3x43A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae)
5 / 12 VAL A 198
ALA A 200
LEU A 209
LEU A 231
THR A 174
None
1.14A 1qzfB-3x43A:
2.4
1qzfB-3x43A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae)
5 / 12 VAL A 198
ALA A 200
LEU A 209
LEU A 231
THR A 174
None
1.15A 1qzfC-3x43A:
2.5
1qzfC-3x43A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae)
5 / 12 VAL A 198
ALA A 200
LEU A 209
LEU A 231
THR A 174
None
1.14A 1qzfD-3x43A:
2.6
1qzfD-3x43A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae)
5 / 12 VAL A 198
ALA A 200
LEU A 209
LEU A 231
THR A 174
None
1.14A 1qzfE-3x43A:
2.5
1qzfE-3x43A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae)
4 / 7 LEU A 222
ARG A 248
SER A 251
TYR A  97
PLP  A 401 (-4.8A)
None
None
None
1.17A 2hc4A-3x43A:
undetectable
2hc4A-3x43A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_A_ANWA99_0
(PROTEIN S100-A13)
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae)
4 / 7 VAL A 245
THR A 246
THR A 250
ARG A 253
None
0.91A 2kotA-3x43A:
undetectable
2kotA-3x43A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae)
5 / 11 LEU A 189
VAL A 235
GLN A 187
ILE A 160
PHE A 172
None
1.15A 2q6hA-3x43A:
undetectable
2q6hA-3x43A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae)
5 / 12 LEU A 189
VAL A 235
GLN A 187
ILE A 160
PHE A 172
None
1.17A 2qb4A-3x43A:
undetectable
2qb4A-3x43A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae)
5 / 11 LEU A 189
VAL A 235
GLN A 187
ILE A 160
PHE A 172
None
1.15A 2qeiA-3x43A:
undetectable
2qeiA-3x43A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae)
4 / 5 GLN A 142
PHE A 143
PHE A 226
GLY A 123
None
1.36A 2qmzA-3x43A:
undetectable
2qmzB-3x43A:
undetectable
2qmzA-3x43A:
21.16
2qmzB-3x43A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae)
4 / 5 GLN A 142
PHE A 143
PHE A 226
GLY A 124
None
1.05A 2qmzA-3x43A:
undetectable
2qmzB-3x43A:
undetectable
2qmzA-3x43A:
21.16
2qmzB-3x43A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_A_SAMA1248_0
(NON-STRUCTURAL
PROTEIN 5)
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae)
5 / 12 GLY A  39
GLY A  72
GLY A  75
THR A  70
THR A  96
None
1.25A 2wa2A-3x43A:
undetectable
2wa2A-3x43A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_0
(CATECHOL
O-METHYLTRANSFERASE)
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae)
5 / 12 VAL A  51
GLY A  75
TYR A  87
TYR A 108
SER A  71
None
1.35A 2zthA-3x43A:
4.7
2zthA-3x43A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae)
4 / 4 GLY A  72
VAL A  74
GLY A 177
THR A 179
None
None
PLP  A 401 (-3.8A)
None
0.84A 3ib2A-3x43A:
undetectable
3ib2A-3x43A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae)
4 / 7 ASN A 145
ALA A 147
ARG A  85
ALA A  54
None
1.02A 3twpA-3x43A:
undetectable
3twpA-3x43A:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae)
5 / 12 VAL A 198
ALA A 200
LEU A 209
ARG A 190
THR A 174
None
1.19A 4eckB-3x43A:
2.2
4eckB-3x43A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae)
5 / 10 GLY A 120
GLY A 123
GLN A 142
PHE A 143
PHE A 226
None
1.45A 4fgkA-3x43A:
undetectable
4fgkB-3x43A:
undetectable
4fgkA-3x43A:
22.39
4fgkB-3x43A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae)
5 / 10 GLY A 124
GLY A 123
GLN A 142
PHE A 143
PHE A 226
None
1.27A 4fgkA-3x43A:
undetectable
4fgkB-3x43A:
undetectable
4fgkA-3x43A:
22.39
4fgkB-3x43A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae)
5 / 12 GLY A 123
ILE A 127
GLN A 142
PHE A 143
PHE A 226
None
1.21A 4fglA-3x43A:
undetectable
4fglB-3x43A:
undetectable
4fglA-3x43A:
22.39
4fglB-3x43A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae)
5 / 12 GLY A 124
GLY A 123
GLN A 142
PHE A 143
PHE A 226
None
1.26A 4fglA-3x43A:
undetectable
4fglB-3x43A:
undetectable
4fglA-3x43A:
22.39
4fglB-3x43A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_B_CLQB303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae)
5 / 11 GLN A 142
PHE A 143
PHE A 226
GLY A 120
GLY A 123
None
1.42A 4fglA-3x43A:
undetectable
4fglB-3x43A:
undetectable
4fglA-3x43A:
22.39
4fglB-3x43A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_B_CLQB303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae)
5 / 11 GLN A 142
PHE A 143
PHE A 226
GLY A 124
GLY A 123
None
1.29A 4fglA-3x43A:
undetectable
4fglB-3x43A:
undetectable
4fglA-3x43A:
22.39
4fglB-3x43A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae)
5 / 12 VAL A 198
ALA A 200
LEU A 209
LEU A 231
THR A 174
None
1.13A 4ky8A-3x43A:
undetectable
4ky8A-3x43A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae)
5 / 12 VAL A 198
ALA A 200
LEU A 209
LEU A 231
THR A 174
None
1.08A 4ky8C-3x43A:
undetectable
4ky8C-3x43A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae)
5 / 12 VAL A 198
ALA A 200
LEU A 209
LEU A 231
THR A 174
None
1.10A 4ky8E-3x43A:
2.0
4ky8E-3x43A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae)
5 / 12 VAL A 198
ALA A 200
LEU A 209
LEU A 231
THR A 174
None
1.11A 4q0dA-3x43A:
undetectable
4q0dA-3x43A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae)
5 / 12 VAL A 198
ALA A 200
LEU A 209
LEU A 231
THR A 174
None
1.11A 4q0dB-3x43A:
undetectable
4q0dB-3x43A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae)
5 / 12 VAL A 198
ALA A 200
LEU A 209
LEU A 231
THR A 174
None
1.11A 4q0dE-3x43A:
undetectable
4q0dE-3x43A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae)
6 / 12 THR A 300
GLY A 263
GLY A 294
ALA A 271
THR A 272
ALA A 247
None
1.44A 4uckA-3x43A:
undetectable
4uckA-3x43A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae)
6 / 12 THR A 300
GLY A 263
GLY A 294
ALA A 271
THR A 272
ALA A 247
None
1.44A 4uckB-3x43A:
undetectable
4uckB-3x43A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae)
4 / 6 ASP A 170
THR A 272
THR A 269
VAL A 173
None
1.00A 4yoaA-3x43A:
undetectable
4yoaA-3x43A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae)
5 / 11 GLN A 142
PHE A 143
PHE A 226
GLY A 124
GLY A 123
None
1.33A 4zvmA-3x43A:
undetectable
4zvmB-3x43A:
undetectable
4zvmA-3x43A:
21.16
4zvmB-3x43A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae)
4 / 5 PRO A 291
HIS A 217
LEU A 239
PHE A 226
PLP  A 401 (-4.1A)
None
None
None
1.20A 5igjA-3x43A:
undetectable
5igjA-3x43A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_B_SALB503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae)
4 / 7 THR A 181
HIS A 152
MET A 289
THR A  14
PLP  A 401 (-3.6A)
PLP  A 401 ( 4.9A)
None
None
1.37A 5u6mB-3x43A:
3.3
5u6mB-3x43A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae)
3 / 3 THR A  14
GLU A 159
HIS A 152
None
None
PLP  A 401 ( 4.9A)
0.90A 5xioA-3x43A:
undetectable
5xioA-3x43A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae)
3 / 3 THR A  14
GLU A 159
HIS A 152
None
None
PLP  A 401 ( 4.9A)
0.91A 5xiqB-3x43A:
undetectable
5xiqB-3x43A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae)
3 / 3 THR A  14
GLU A 159
HIS A 152
None
None
PLP  A 401 ( 4.9A)
0.91A 5xiqD-3x43A:
undetectable
5xiqD-3x43A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae)
5 / 9 THR A 181
GLY A 184
GLY A 186
VAL A 196
GLU A 159
PLP  A 401 (-3.6A)
None
None
None
None
1.49A 6gnfA-3x43A:
2.8
6gnfA-3x43A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae)
4 / 6 VAL A  81
ASN A  37
PRO A  38
ILE A  11
None
1.24A 6h7uA-3x43A:
undetectable
6h7uA-3x43A:
20.68