SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ypi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 3ypi TRIOSEPHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 204
ALA A 200
LEU A 192
SER A 194
 None
 1.02A 1tz8C-3ypiA:
undetectable
1tz8D-3ypiA:
undetectable		 1tz8C-3ypiA:
17.39
1tz8D-3ypiA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3ypi TRIOSEPHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 195
ASP A 106
ASN A 148
 None
 0.96A 2bm9A-3ypiA:
undetectable		 2bm9A-3ypiA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 3ypi TRIOSEPHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		4 / 5 ILE A  32
PRO A  33
PHE A   5
ILE A 243
 None
 1.04A 2hjhA-3ypiA:
undetectable		 2hjhA-3ypiA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 3ypi TRIOSEPHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		5 / 10 PHE A   6
SER A  50
LEU A 125
ILE A  20
GLY A   8
 None
 0.92A 2v0mA-3ypiA:
undetectable		 2v0mA-3ypiA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 3ypi TRIOSEPHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		4 / 7 PHE A   6
SER A  50
ILE A  20
GLY A   8
 None
 0.64A 2v0mC-3ypiA:
undetectable		 2v0mC-3ypiA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 3ypi TRIOSEPHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 169
ALA A 176
PHE A 229
SER A 211
ALA A 212
 None
None
None
PGH  A 249 (-3.7A)
None
 1.49A 2vh3A-3ypiA:
undetectable		 2vh3A-3ypiA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 3ypi TRIOSEPHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		4 / 6 VAL A 150
LEU A 147
ILE A 127
VAL A 160
 None
 0.89A 4a9kA-3ypiA:
undetectable		 4a9kA-3ypiA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3ypi TRIOSEPHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 242
ILE A 243
PHE A 240
GLY A   9
 None
 0.78A 4acaC-3ypiA:
3.4		 4acaC-3ypiA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3ypi TRIOSEPHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 242
ILE A 243
PHE A 240
GLY A   9
 None
 0.69A 4acbC-3ypiA:
3.2		 4acbC-3ypiA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3ypi TRIOSEPHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 124
VAL A 143
ILE A 127
GLU A 129
GLU A 133
 None
 1.39A 4i41A-3ypiA:
undetectable		 4i41A-3ypiA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 3ypi TRIOSEPHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		5 / 11 LEU A  93
VAL A 121
ILE A  83
SER A  79
LEU A  47
 None
 1.39A 4lhmA-3ypiA:
undetectable		 4lhmA-3ypiA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3ypi TRIOSEPHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		4 / 6 ARG A   3
ASP A 225
HIS A 185
ILE A 206
 None
 1.29A 5a06A-3ypiA:
undetectable		 5a06A-3ypiA:
22.46