SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zby'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacteriu
m
smegmatis)
5 / 11 LEU A 229
GLY A 233
THR A 237
VAL A 280
VAL A 383
HEM  A1402 ( 4.6A)
EDO  A1406 ( 3.4A)
HEM  A1402 (-3.7A)
HEM  A1402 (-4.4A)
None
0.90A 1akdA-3zbyA:
41.7
1akdA-3zbyA:
30.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacteriu
m
smegmatis)
4 / 6 ASP A  11
ASN A  41
ASP A  39
TYR A  18
None
1.28A 1hpkA-3zbyA:
undetectable
1hpkA-3zbyA:
10.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacteriu
m
smegmatis)
5 / 11 LEU A 229
GLY A 233
THR A 237
VAL A 280
VAL A 383
HEM  A1402 ( 4.6A)
EDO  A1406 ( 3.4A)
HEM  A1402 (-3.7A)
HEM  A1402 (-4.4A)
None
1.03A 1phgA-3zbyA:
42.4
1phgA-3zbyA:
30.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacteriu
m
smegmatis)
5 / 12 MET A 356
LEU A 242
SER A 396
PHE A 128
ILE A 132
None
1.27A 1xosA-3zbyA:
undetectable
1xosA-3zbyA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacteriu
m
smegmatis)
3 / 3 GLN A 248
HIS A 252
ARG A 253
None
0.99A 1zlqA-3zbyA:
undetectable
1zlqA-3zbyA:
22.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacteriu
m
smegmatis)
5 / 11 LEU A 229
GLY A 233
THR A 237
VAL A 280
VAL A 383
HEM  A1402 ( 4.6A)
EDO  A1406 ( 3.4A)
HEM  A1402 (-3.7A)
HEM  A1402 (-4.4A)
None
0.69A 2a1nA-3zbyA:
42.5
2a1nA-3zbyA:
30.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacteriu
m
smegmatis)
4 / 7 GLY A 234
GLY A 233
VAL A 140
LEU A 348
HEM  A1402 (-3.3A)
EDO  A1406 ( 3.4A)
None
HEM  A1402 ( 4.7A)
0.68A 2oa1B-3zbyA:
undetectable
2oa1B-3zbyA:
21.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacteriu
m
smegmatis)
5 / 11 ILE A  79
LEU A 229
ILE A 232
THR A 237
VAL A 280
HEM  A1402 (-4.2A)
HEM  A1402 ( 4.6A)
None
HEM  A1402 (-3.7A)
HEM  A1402 (-4.4A)
0.63A 3a51A-3zbyA:
43.1
3a51A-3zbyA:
36.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacteriu
m
smegmatis)
5 / 12 ILE A  79
LEU A 229
ILE A 232
THR A 237
VAL A 280
HEM  A1402 (-4.2A)
HEM  A1402 ( 4.6A)
None
HEM  A1402 (-3.7A)
HEM  A1402 (-4.4A)
0.61A 3a51D-3zbyA:
42.8
3a51D-3zbyA:
36.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacteriu
m
smegmatis)
4 / 4 LEU A 116
ALA A 139
VAL A 140
PRO A 137
None
1.15A 3gv1B-3zbyA:
undetectable
3gv1B-3zbyA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacteriu
m
smegmatis)
5 / 10 LEU A 229
GLY A 233
THR A 237
VAL A 280
VAL A 383
HEM  A1402 ( 4.6A)
EDO  A1406 ( 3.4A)
HEM  A1402 (-3.7A)
HEM  A1402 (-4.4A)
None
0.75A 3lxiA-3zbyA:
41.6
3lxiA-3zbyA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacteriu
m
smegmatis)
5 / 11 LEU A 229
GLY A 233
THR A 237
VAL A 280
VAL A 383
HEM  A1402 ( 4.6A)
EDO  A1406 ( 3.4A)
HEM  A1402 (-3.7A)
HEM  A1402 (-4.4A)
None
0.78A 3lxiB-3zbyA:
41.5
3lxiB-3zbyA:
28.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacteriu
m
smegmatis)
4 / 5 LEU A 229
GLY A 233
THR A 237
VAL A 383
HEM  A1402 ( 4.6A)
EDO  A1406 ( 3.4A)
HEM  A1402 (-3.7A)
None
0.55A 3wriA-3zbyA:
44.3
3wriA-3zbyA:
31.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacteriu
m
smegmatis)
4 / 5 LEU A 229
GLY A 233
THR A 237
VAL A 383
HEM  A1402 ( 4.6A)
EDO  A1406 ( 3.4A)
HEM  A1402 (-3.7A)
None
0.55A 3wriB-3zbyA:
44.3
3wriB-3zbyA:
31.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacteriu
m
smegmatis)
4 / 5 LEU A 229
GLY A 233
THR A 237
VAL A 280
HEM  A1402 ( 4.6A)
EDO  A1406 ( 3.4A)
HEM  A1402 (-3.7A)
HEM  A1402 (-4.4A)
0.89A 3wrkD-3zbyA:
43.2
3wrkD-3zbyA:
31.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacteriu
m
smegmatis)
4 / 5 LEU A 229
GLY A 233
THR A 237
VAL A 383
HEM  A1402 ( 4.6A)
EDO  A1406 ( 3.4A)
HEM  A1402 (-3.7A)
None
0.41A 3wrkD-3zbyA:
43.2
3wrkD-3zbyA:
31.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacteriu
m
smegmatis)
5 / 9 LEU A 229
GLY A 233
THR A 237
VAL A 280
VAL A 383
HEM  A1402 ( 4.6A)
EDO  A1406 ( 3.4A)
HEM  A1402 (-3.7A)
HEM  A1402 (-4.4A)
None
0.90A 4c9kB-3zbyA:
41.7
4c9kB-3zbyA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacteriu
m
smegmatis)
5 / 12 ILE A  68
GLY A 234
THR A 237
VAL A 280
VAL A 383
None
HEM  A1402 (-3.3A)
HEM  A1402 (-3.7A)
HEM  A1402 (-4.4A)
None
0.77A 4c9lA-3zbyA:
41.9
4c9lA-3zbyA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacteriu
m
smegmatis)
5 / 12 ILE A  68
LEU A 229
THR A 237
VAL A 280
VAL A 383
None
HEM  A1402 ( 4.6A)
HEM  A1402 (-3.7A)
HEM  A1402 (-4.4A)
None
0.63A 4c9lA-3zbyA:
41.9
4c9lA-3zbyA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacteriu
m
smegmatis)
5 / 12 LEU A 229
GLY A 233
THR A 237
VAL A 280
VAL A 383
HEM  A1402 ( 4.6A)
EDO  A1406 ( 3.4A)
HEM  A1402 (-3.7A)
HEM  A1402 (-4.4A)
None
0.70A 4c9lA-3zbyA:
41.9
4c9lA-3zbyA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacteriu
m
smegmatis)
5 / 12 ILE A  68
GLY A 234
THR A 237
VAL A 280
VAL A 383
None
HEM  A1402 (-3.3A)
HEM  A1402 (-3.7A)
HEM  A1402 (-4.4A)
None
0.78A 4c9lB-3zbyA:
41.7
4c9lB-3zbyA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacteriu
m
smegmatis)
5 / 12 ILE A  68
LEU A 229
THR A 237
VAL A 280
VAL A 383
None
HEM  A1402 ( 4.6A)
HEM  A1402 (-3.7A)
HEM  A1402 (-4.4A)
None
0.58A 4c9lB-3zbyA:
41.7
4c9lB-3zbyA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacteriu
m
smegmatis)
5 / 12 LEU A 229
GLY A 233
THR A 237
VAL A 280
VAL A 383
HEM  A1402 ( 4.6A)
EDO  A1406 ( 3.4A)
HEM  A1402 (-3.7A)
HEM  A1402 (-4.4A)
None
0.73A 4c9lB-3zbyA:
41.7
4c9lB-3zbyA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacteriu
m
smegmatis)
5 / 12 ILE A  68
GLY A 234
THR A 237
VAL A 280
VAL A 383
None
HEM  A1402 (-3.3A)
HEM  A1402 (-3.7A)
HEM  A1402 (-4.4A)
None
0.76A 4c9oA-3zbyA:
41.8
4c9oA-3zbyA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacteriu
m
smegmatis)
5 / 12 ILE A  68
LEU A 229
THR A 237
VAL A 280
VAL A 383
None
HEM  A1402 ( 4.6A)
HEM  A1402 (-3.7A)
HEM  A1402 (-4.4A)
None
0.70A 4c9oA-3zbyA:
41.8
4c9oA-3zbyA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacteriu
m
smegmatis)
5 / 12 LEU A 229
GLY A 233
THR A 237
VAL A 280
VAL A 383
HEM  A1402 ( 4.6A)
EDO  A1406 ( 3.4A)
HEM  A1402 (-3.7A)
HEM  A1402 (-4.4A)
None
0.75A 4c9oA-3zbyA:
41.8
4c9oA-3zbyA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacteriu
m
smegmatis)
5 / 12 ILE A  68
GLY A 234
THR A 237
VAL A 280
VAL A 383
None
HEM  A1402 (-3.3A)
HEM  A1402 (-3.7A)
HEM  A1402 (-4.4A)
None
0.77A 4c9oB-3zbyA:
41.8
4c9oB-3zbyA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacteriu
m
smegmatis)
5 / 12 ILE A  68
LEU A 229
THR A 237
VAL A 280
VAL A 383
None
HEM  A1402 ( 4.6A)
HEM  A1402 (-3.7A)
HEM  A1402 (-4.4A)
None
0.70A 4c9oB-3zbyA:
41.8
4c9oB-3zbyA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacteriu
m
smegmatis)
5 / 12 LEU A 229
GLY A 233
THR A 237
VAL A 280
VAL A 383
HEM  A1402 ( 4.6A)
EDO  A1406 ( 3.4A)
HEM  A1402 (-3.7A)
HEM  A1402 (-4.4A)
None
0.75A 4c9oB-3zbyA:
41.8
4c9oB-3zbyA:
28.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacteriu
m
smegmatis)
5 / 10 LEU A 229
GLY A 233
THR A 237
VAL A 280
VAL A 383
HEM  A1402 ( 4.6A)
EDO  A1406 ( 3.4A)
HEM  A1402 (-3.7A)
HEM  A1402 (-4.4A)
None
0.67A 4jx1B-3zbyA:
44.3
4jx1B-3zbyA:
30.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacteriu
m
smegmatis)
4 / 8 ARG A  24
ARG A 275
ARG A 328
GLU A 247
None
0.94A 4kr4C-3zbyA:
undetectable
4kr4C-3zbyA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacteriu
m
smegmatis)
4 / 7 PHE A 382
ILE A  68
PHE A 308
ARG A 285
None
None
HEM  A1402 ( 4.4A)
HEM  A1402 (-3.2A)
1.11A 4o7gA-3zbyA:
undetectable
4o7gB-3zbyA:
1.3
4o7gA-3zbyA:
21.14
4o7gB-3zbyA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacteriu
m
smegmatis)
4 / 5 GLY A 142
ILE A 230
LEU A 348
LEU A 116
None
HEM  A1402 (-4.4A)
HEM  A1402 ( 4.7A)
None
0.79A 4o8fA-3zbyA:
undetectable
4o8fA-3zbyA:
21.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacteriu
m
smegmatis)
5 / 9 LEU A 229
GLY A 233
THR A 237
VAL A 280
VAL A 383
HEM  A1402 ( 4.6A)
EDO  A1406 ( 3.4A)
HEM  A1402 (-3.7A)
HEM  A1402 (-4.4A)
None
0.89A 5cp4A-3zbyA:
42.5
5cp4A-3zbyA:
30.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacteriu
m
smegmatis)
3 / 3 ARG A  69
ASN A 381
ASP A  39
None
0.93A 5gwxA-3zbyA:
undetectable
5gwxA-3zbyA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacteriu
m
smegmatis)
3 / 3 LYS A 157
ASP A 153
ILE A 232
None
0.87A 5kc4E-3zbyA:
2.1
5kc4E-3zbyA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacteriu
m
smegmatis)
4 / 7 ARG A  89
LEU A 204
THR A 189
ARG A 217
None
0.99A 5vc0A-3zbyA:
17.5
5vc0A-3zbyA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacteriu
m
smegmatis)
4 / 5 GLY A 339
THR A 340
SER A  63
SER A  64
None
0.99A 6jmjA-3zbyA:
undetectable
6jmjA-3zbyA:
18.58