SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zc4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 3zc4 SSO1398
(Sulfolobus
solfataricus) 		3 / 3 TYR A 107
VAL A 122
THR A 105
 None
 0.61A 2ygnA-3zc4A:
undetectable		 2ygnA-3zc4A:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 3zc4 SSO1398
(Sulfolobus
solfataricus) 		3 / 3 PRO A 132
PHE A  24
LYS A  20
 None
 0.93A 3bjwG-3zc4A:
undetectable		 3bjwG-3zc4A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 3zc4 SSO1398
(Sulfolobus
solfataricus) 		4 / 7 LEU A  54
VAL A 136
LEU A 154
LEU A  86
 None
 0.86A 3g8iA-3zc4A:
undetectable		 3g8iA-3zc4A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)		 3zc4 SSO1398
(Sulfolobus
solfataricus) 		5 / 7 ILE A  19
ILE A  11
VAL A 153
LEU A 157
SER A 156
 None
 1.35A 3r9vA-3zc4A:
undetectable
3r9vB-3zc4A:
undetectable		 3r9vA-3zc4A:
21.62
3r9vB-3zc4A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 3zc4 SSO1398
(Sulfolobus
solfataricus) 		4 / 5 TYR A 102
ILE A 106
ASN A  97
ILE A  94
 None
 0.97A 4jtpA-3zc4A:
undetectable		 4jtpA-3zc4A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3zc4 SSO1398
(Sulfolobus
solfataricus) 		3 / 3 ASP A 145
LEU A 144
PHE A 141
 None
 0.38A 4pthA-3zc4A:
undetectable		 4pthA-3zc4A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 3zc4 SSO1398
(Sulfolobus
solfataricus) 		5 / 10 PRO A 132
LEU A  50
ILE A  46
PHE A 140
PRO A  36
 None
 1.34A 5m0oA-3zc4A:
undetectable		 5m0oA-3zc4A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3zc4 SSO1398
(Sulfolobus
solfataricus) 		5 / 10 LEU A  22
LEU A  54
ILE A  34
PRO A  36
GLY A  32
 None
 1.10A 6dm0B-3zc4A:
undetectable
6dm0C-3zc4A:
undetectable		 6dm0B-3zc4A:
18.12
6dm0C-3zc4A:
18.12