SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zcb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_2
(ALPHA-AMYLASE)		 3zcb ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE VBHT
(Bartonella
schoenbuchensis) 		3 / 3 TRP A  74
TYR A  20
LEU A  31
 None
None
GOL  A1199 ( 4.9A)
 0.90A 1kxhA-3zcbA:
undetectable		 1kxhA-3zcbA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZY_A_CHDA237_0
(PHOSPHOLIPASE A2,
MAJOR ISOENZYME)		 3zcb ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE VBHT
(Bartonella
schoenbuchensis) 		5 / 11 ARG A 191
ILE A 190
ILE A 150
TYR A 127
TYR A 128
 None
 1.15A 2azyA-3zcbA:
undetectable		 2azyA-3zcbA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6U_A_BEZA501_0
(NIKD PROTEIN)		 3zcb ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE VBHT
(Bartonella
schoenbuchensis) 		4 / 7 HIS A 112
ARG A 114
GLU A 156
PHE A  55
 None
 1.49A 2q6uA-3zcbA:
0.0		 2q6uA-3zcbA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3zcb ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE VBHT
(Bartonella
schoenbuchensis) 		5 / 12 ALA A 100
PRO A 101
THR A 145
ASP A  58
PHE A 149
 None
 1.11A 2v95A-3zcbA:
undetectable		 2v95A-3zcbA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3zcb ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE VBHT
(Bartonella
schoenbuchensis) 		4 / 5 ASN A 142
GLU A  35
TYR A  72
PHE A  68
 ATP  A 300 (-3.8A)
GOL  A1199 (-2.7A)
None
None
 1.40A 4twdC-3zcbA:
1.4
4twdD-3zcbA:
1.9		 4twdC-3zcbA:
20.39
4twdD-3zcbA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 3zcb ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE VBHT
(Bartonella
schoenbuchensis) 		5 / 12 ILE A  96
ALA A 100
THR A 104
ILE A 150
GLY A 130
 None
 0.90A 5veuB-3zcbA:
undetectable		 5veuB-3zcbA:
19.69