SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zcw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 3zcw KINESIN-LIKE PROTEIN
KIF11
(Homo
sapiens) 		5 / 9 ILE A  19
LEU A 316
VAL A 298
GLY A 296
LEU A 324
 None
None
None
4A2  A1366 (-3.4A)
None
 1.26A 1e7aB-3zcwA:
undetectable		 1e7aB-3zcwA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 3zcw KINESIN-LIKE PROTEIN
KIF11
(Homo
sapiens) 		4 / 6 ASN A 190
ILE A 319
ASN A 262
ASN A  98
 None
 1.00A 1h7xA-3zcwA:
undetectable		 1h7xA-3zcwA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 3zcw KINESIN-LIKE PROTEIN
KIF11
(Homo
sapiens) 		4 / 6 ASN A 190
ILE A 319
ASN A 262
ASN A  98
 None
 1.01A 1h7xB-3zcwA:
undetectable		 1h7xB-3zcwA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 3zcw KINESIN-LIKE PROTEIN
KIF11
(Homo
sapiens) 		4 / 6 ASN A 190
ILE A 319
ASN A 262
ASN A  98
 None
 1.00A 1h7xC-3zcwA:
undetectable		 1h7xC-3zcwA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 3zcw KINESIN-LIKE PROTEIN
KIF11
(Homo
sapiens) 		4 / 6 ASN A 190
ILE A 319
ASN A 262
ASN A  98
 None
 1.02A 1h7xD-3zcwA:
undetectable		 1h7xD-3zcwA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3zcw KINESIN-LIKE PROTEIN
KIF11
(Homo
sapiens) 		3 / 3 LEU A 341
HIS A  38
ILE A  40
 None
 0.70A 1s9pB-3zcwA:
undetectable		 1s9pB-3zcwA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 3zcw KINESIN-LIKE PROTEIN
KIF11
(Homo
sapiens) 		3 / 3 ARG A 192
GLY A 193
SER A 240
 None
 0.62A 2xctB-3zcwA:
undetectable		 2xctB-3zcwA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3zcw KINESIN-LIKE PROTEIN
KIF11
(Homo
sapiens) 		5 / 12 ILE A 319
MET A 115
VAL A  86
LEU A  90
ILE A 101
 None
 1.34A 3em0B-3zcwA:
undetectable		 3em0B-3zcwA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3zcw KINESIN-LIKE PROTEIN
KIF11
(Homo
sapiens) 		4 / 6 GLY A 134
THR A 139
GLU A 118
GLU A 215
 None
None
ADP  A1364 (-3.8A)
None
 1.09A 3fpjA-3zcwA:
undetectable		 3fpjA-3zcwA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3zcw KINESIN-LIKE PROTEIN
KIF11
(Homo
sapiens) 		3 / 3 ARG A 234
THR A 349
THR A 112
 None
None
MG  A1365 ( 3.0A)
 0.78A 3k2hB-3zcwA:
undetectable		 3k2hB-3zcwA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 3zcw KINESIN-LIKE PROTEIN
KIF11
(Homo
sapiens) 		4 / 6 GLY A 151
THR A 152
LEU A 147
ASP A 149
 None
 0.84A 3ps9A-3zcwA:
undetectable		 3ps9A-3zcwA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3zcw KINESIN-LIKE PROTEIN
KIF11
(Homo
sapiens) 		5 / 12 VAL A 264
LEU A 160
SER A 159
ILE A 163
LEU A 168
 None
4A2  A1367 (-4.9A)
None
None
None
 1.16A 3w68A-3zcwA:
undetectable		 3w68A-3zcwA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 3zcw KINESIN-LIKE PROTEIN
KIF11
(Homo
sapiens) 		4 / 8 VAL A 210
VAL A 204
LYS A 207
ILE A 143
 None
 0.75A 3warA-3zcwA:
undetectable		 3warA-3zcwA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1105_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3zcw KINESIN-LIKE PROTEIN
KIF11
(Homo
sapiens) 		5 / 11 MET A  70
THR A 114
GLY A 134
ARG A 329
GLN A  78
 None
 1.42A 4dx7A-3zcwA:
0.4		 4dx7A-3zcwA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 3zcw KINESIN-LIKE PROTEIN
KIF11
(Homo
sapiens) 		4 / 5 LEU A 295
GLY A 296
ILE A 332
LYS A  18
 4A2  A1366 (-4.1A)
4A2  A1366 (-3.4A)
4A2  A1366 (-3.9A)
None
 1.00A 4ma8C-3zcwA:
undetectable		 4ma8C-3zcwA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 3zcw KINESIN-LIKE PROTEIN
KIF11
(Homo
sapiens) 		5 / 12 ILE A 196
THR A 100
SER A 240
LEU A 295
LEU A 316
 None
None
None
4A2  A1366 (-4.1A)
None
 1.15A 4qztA-3zcwA:
undetectable		 4qztA-3zcwA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 3zcw KINESIN-LIKE PROTEIN
KIF11
(Homo
sapiens) 		5 / 12 VAL A 210
VAL A 204
LEU A 172
LEU A  90
ILE A 101
 None
 1.24A 5hv1A-3zcwA:
undetectable		 5hv1A-3zcwA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 3zcw KINESIN-LIKE PROTEIN
KIF11
(Homo
sapiens) 		4 / 8 ILE A  19
LEU A 320
ILE A 332
THR A 328
 None
None
4A2  A1366 (-3.9A)
None
 0.66A 5uihA-3zcwA:
undetectable		 5uihA-3zcwA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 3zcw KINESIN-LIKE PROTEIN
KIF11
(Homo
sapiens) 		4 / 7 GLY A 217
ILE A 136
GLN A  78
TRP A 127
 4A2  A1367 (-3.3A)
4A2  A1367 (-3.4A)
None
None
 0.83A 5vlmC-3zcwA:
undetectable		 5vlmC-3zcwA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 3zcw KINESIN-LIKE PROTEIN
KIF11
(Homo
sapiens) 		4 / 8 GLY A 217
ILE A 136
GLN A  78
TRP A 127
 4A2  A1367 (-3.3A)
4A2  A1367 (-3.4A)
None
None
 0.89A 5vlmD-3zcwA:
undetectable		 5vlmD-3zcwA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_O_CHDO302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3zcw KINESIN-LIKE PROTEIN
KIF11
(Homo
sapiens) 		5 / 11 GLY A 110
GLY A 268
GLN A 106
THR A 346
THR A 349
 ADP  A1364 (-3.1A)
None
None
None
None
 1.27A 5x1bG-3zcwA:
undetectable
5x1bN-3zcwA:
0.5
5x1bO-3zcwA:
undetectable		 5x1bG-3zcwA:
13.51
5x1bN-3zcwA:
19.81
5x1bO-3zcwA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3zcw KINESIN-LIKE PROTEIN
KIF11
(Homo
sapiens) 		4 / 7 VAL A 210
VAL A 204
LYS A 207
ILE A 143
 None
 0.83A 5yf9B-3zcwA:
undetectable		 5yf9B-3zcwA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3zcw KINESIN-LIKE PROTEIN
KIF11
(Homo
sapiens) 		4 / 6 PHE A  68
LEU A 347
LEU A 350
HIS A 354
 None
 0.73A 6e43A-3zcwA:
undetectable		 6e43A-3zcwA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3zcw KINESIN-LIKE PROTEIN
KIF11
(Homo
sapiens) 		4 / 6 PHE A  68
LEU A 347
LEU A 350
HIS A 354
 None
 0.80A 6e43B-3zcwA:
undetectable		 6e43B-3zcwA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3zcw KINESIN-LIKE PROTEIN
KIF11
(Homo
sapiens) 		4 / 6 PHE A  68
LEU A 347
LEU A 350
HIS A 354
 None
 0.73A 6e43C-3zcwA:
undetectable		 6e43C-3zcwA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3zcw KINESIN-LIKE PROTEIN
KIF11
(Homo
sapiens) 		4 / 6 PHE A  68
LEU A 347
LEU A 350
HIS A 354
 None
 0.79A 6e43D-3zcwA:
undetectable		 6e43D-3zcwA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 3zcw KINESIN-LIKE PROTEIN
KIF11
(Homo
sapiens) 		4 / 6 ASN A  98
VAL A  93
VAL A 241
THR A 242
 None
 1.23A 6f32B-3zcwA:
undetectable		 6f32B-3zcwA:
21.74