SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zdb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)		 3zdb PROTEIN XNI
(Escherichia
coli) 		4 / 4 HIS A 119
VAL A 114
THR A  43
LEU A   6
 None
 1.48A 1oq5A-3zdbA:
undetectable		 1oq5A-3zdbA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 3zdb PROTEIN XNI
(Escherichia
coli) 		4 / 7 LEU A 249
THR A  43
PRO A  42
HIS A   4
 None
 0.73A 2ddwB-3zdbA:
undetectable		 2ddwB-3zdbA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 3zdb PROTEIN XNI
(Escherichia
coli) 		5 / 12 PHE A  88
ALA A  47
TYR A 143
LEU A  36
GLN A  21
 None
None
ACT  A1254 ( 4.9A)
ACT  A1254 (-4.8A)
None
 1.33A 2rctA-3zdbA:
undetectable		 2rctA-3zdbA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 3zdb PROTEIN XNI
(Escherichia
coli) 		3 / 3 ARG A  15
ARG A  70
PRO A  71
 None
 1.01A 2wljA-3zdbA:
undetectable		 2wljA-3zdbA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3zdb PROTEIN XNI
(Escherichia
coli) 		3 / 3 TYR A  66
GLU A 102
ASN A  12
 None
MG  A1253 ( 4.9A)
None
 0.97A 2y7hC-3zdbA:
undetectable		 2y7hC-3zdbA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3zdb PROTEIN XNI
(Escherichia
coli) 		5 / 12 GLY A 181
GLY A 170
ILE A 185
ALA A 183
LEU A 227
 K  A1251 ( 4.4A)
None
None
None
None
 1.09A 3ckkA-3zdbA:
undetectable		 3ckkA-3zdbA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 3zdb PROTEIN XNI
(Escherichia
coli) 		5 / 12 GLY A 173
ALA A 225
ALA A 232
ILE A 185
ALA A 190
 K  A1251 ( 4.4A)
None
None
None
None
 1.07A 3jb1A-3zdbA:
undetectable		 3jb1A-3zdbA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)		 3zdb PROTEIN XNI
(Escherichia
coli) 		3 / 3 GLU A 102
ASP A 105
ASP A 127
 MG  A1253 ( 4.9A)
None
None
 0.72A 3jb2A-3zdbA:
2.7		 3jb2A-3zdbA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 3zdb PROTEIN XNI
(Escherichia
coli) 		4 / 7 ARG A  59
LEU A  63
ARG A  62
GLY A 170
 None
 0.90A 4cp3A-3zdbA:
undetectable
4cp3B-3zdbA:
undetectable		 4cp3A-3zdbA:
16.73
4cp3B-3zdbA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 3zdb PROTEIN XNI
(Escherichia
coli) 		3 / 3 SER A 177
TYR A  66
ASP A 127
 None
 0.89A 4rp8C-3zdbA:
undetectable		 4rp8C-3zdbA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3zdb PROTEIN XNI
(Escherichia
coli) 		4 / 4 VAL A  48
LEU A  11
ASN A 101
ASP A 105
 None
 1.29A 5vcyA-3zdbA:
undetectable		 5vcyA-3zdbA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3zdb PROTEIN XNI
(Escherichia
coli) 		5 / 12 ALA A  47
ALA A 103
ILE A  17
CYH A  29
LEU A  33
 None
MG  A1255 ( 4.8A)
None
None
None
 1.06A 6a60D-3zdbA:
undetectable		 6a60D-3zdbA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 3zdb PROTEIN XNI
(Escherichia
coli) 		5 / 10 ALA A  10
LEU A  13
VAL A   8
ILE A  37
ALA A  87
 None
 1.17A 6h1lA-3zdbA:
undetectable		 6h1lA-3zdbA:
20.04