SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zdf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 3zdf GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Thermosynechococ
cus
elongatus) 		4 / 7 ASN A 317
TYR A 321
ASN A 157
TYR A 315
 NAD  A1001 (-3.7A)
NAD  A1001 (-3.5A)
None
None
 0.92A 1dssG-3zdfA:
49.5		 1dssG-3zdfA:
46.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 3zdf GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Thermosynechococ
cus
elongatus) 		7 / 7 SER A 153
THR A 155
ASN A 157
CYH A 158
TYR A 315
ASN A 317
TYR A 321
 None
None
None
None
None
NAD  A1001 (-3.7A)
NAD  A1001 (-3.5A)
 0.17A 1dssG-3zdfA:
49.5		 1dssG-3zdfA:
46.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 3zdf GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Thermosynechococ
cus
elongatus) 		4 / 8 ASN A 317
TYR A 321
ASN A 157
TYR A 315
 NAD  A1001 (-3.7A)
NAD  A1001 (-3.5A)
None
None
 0.91A 1dssR-3zdfA:
49.4		 1dssR-3zdfA:
46.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 3zdf GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Thermosynechococ
cus
elongatus) 		8 / 8 SER A 153
THR A 155
ASN A 157
CYH A 158
HIS A 181
TYR A 315
ASN A 317
TYR A 321
 None
None
None
None
None
None
NAD  A1001 (-3.7A)
NAD  A1001 (-3.5A)
 0.35A 1dssR-3zdfA:
49.4		 1dssR-3zdfA:
46.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3zdf GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Thermosynechococ
cus
elongatus) 		5 / 11 PRO A 237
GLY A 185
ASP A 186
GLN A 187
ILE A  12
 None
NAD  A1001 ( 4.9A)
None
None
NAD  A1001 (-4.1A)
 1.12A 1jzsA-3zdfA:
undetectable		 1jzsA-3zdfA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3zdf GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Thermosynechococ
cus
elongatus) 		4 / 7 SER A 293
ARG A 324
LEU A 328
HIS A 139
 None
 1.10A 2f78A-3zdfA:
undetectable		 2f78A-3zdfA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3zdf GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Thermosynechococ
cus
elongatus) 		4 / 6 SER A 293
ARG A 324
LEU A 328
HIS A 139
 None
 1.13A 2f8dA-3zdfA:
undetectable		 2f8dA-3zdfA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 3zdf GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Thermosynechococ
cus
elongatus) 		4 / 6 LEU A 220
MET A 177
MET A 176
LEU A 159
 None
 1.23A 2oz7A-3zdfA:
undetectable		 2oz7A-3zdfA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 3zdf GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Thermosynechococ
cus
elongatus) 		4 / 6 ASP A 327
HIS A 335
HIS A 331
HIS A 140
 None
 1.18A 3c0zC-3zdfA:
2.3		 3c0zC-3zdfA:
21.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 3zdf GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Thermosynechococ
cus
elongatus) 		4 / 8 ASN A 317
TYR A 321
ASN A 157
TYR A 315
 NAD  A1001 (-3.7A)
NAD  A1001 (-3.5A)
None
None
 0.94A 3dmtC-3zdfA:
48.9		 3dmtC-3zdfA:
47.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 3zdf GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Thermosynechococ
cus
elongatus) 		8 / 8 SER A 153
THR A 155
ASN A 157
CYH A 158
HIS A 181
TYR A 315
ASN A 317
TYR A 321
 None
None
None
None
None
None
NAD  A1001 (-3.7A)
NAD  A1001 (-3.5A)
 0.27A 3dmtC-3zdfA:
48.9		 3dmtC-3zdfA:
47.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 3zdf GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Thermosynechococ
cus
elongatus) 		5 / 10 ASP A  50
ARG A  11
PHE A   9
ILE A  61
ILE A  55
 None
 1.41A 3ihzA-3zdfA:
undetectable		 3ihzA-3zdfA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 3zdf GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Thermosynechococ
cus
elongatus) 		3 / 3 HIS A 276
HIS A 290
ILE A 295
 None
 0.86A 3u52A-3zdfA:
undetectable
3u52C-3zdfA:
undetectable		 3u52A-3zdfA:
19.70
3u52C-3zdfA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UF8_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3zdf GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Thermosynechococ
cus
elongatus) 		5 / 10 ASP A  50
ARG A  11
PHE A   9
ILE A  61
ILE A  55
 None
 1.46A 3uf8A-3zdfA:
undetectable		 3uf8A-3zdfA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 3zdf GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Thermosynechococ
cus
elongatus) 		5 / 9 ALA A  99
GLY A  10
ASN A  15
ASN A  43
ILE A  34
 NAD  A1001 (-4.9A)
NAD  A1001 (-3.1A)
None
None
None
 1.21A 3wdmA-3zdfA:
2.3		 3wdmA-3zdfA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 3zdf GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Thermosynechococ
cus
elongatus) 		5 / 9 ALA A  99
GLY A  10
ASN A  15
ASN A  43
ILE A  34
 NAD  A1001 (-4.9A)
NAD  A1001 (-3.1A)
None
None
None
 1.22A 3wdmC-3zdfA:
3.5		 3wdmC-3zdfA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 3zdf GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Thermosynechococ
cus
elongatus) 		5 / 10 ALA A  99
GLY A  10
ASN A  15
ASN A  43
ILE A  34
 NAD  A1001 (-4.9A)
NAD  A1001 (-3.1A)
None
None
None
 1.14A 3wdmD-3zdfA:
3.2		 3wdmD-3zdfA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGA_A_ACTA1131_0
(LYSOZYME C)		 3zdf GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Thermosynechococ
cus
elongatus) 		3 / 3 ASN A 240
ASP A 316
ASN A 317
 None
None
NAD  A1001 (-3.7A)
 0.79A 4agaA-3zdfA:
undetectable		 4agaA-3zdfA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 3zdf GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Thermosynechococ
cus
elongatus) 		5 / 12 ILE A 162
LEU A 229
GLY A 219
VAL A 137
VAL A 134
 None
 1.06A 4c9lB-3zdfA:
undetectable		 4c9lB-3zdfA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 3zdf GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Thermosynechococ
cus
elongatus) 		5 / 11 SER A 153
LEU A 159
PRO A 161
VAL A 134
THR A 132
 None
 1.17A 4uuuB-3zdfA:
undetectable		 4uuuB-3zdfA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3zdf GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Thermosynechococ
cus
elongatus) 		5 / 12 LEU A 121
LEU A  95
ILE A  97
ILE A   6
ILE A  31
 None
 0.58A 4y0rA-3zdfA:
undetectable		 4y0rA-3zdfA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 3zdf GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Thermosynechococ
cus
elongatus) 		3 / 3 THR A 156
ALA A 152
ASN A 157
 None
 0.53A 5ersA-3zdfA:
undetectable		 5ersA-3zdfA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 3zdf GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Thermosynechococ
cus
elongatus) 		4 / 7 GLU A  30
ALA A  70
GLY A  72
TYR A  69
 None
 0.78A 5uxdA-3zdfA:
undetectable		 5uxdA-3zdfA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 3zdf GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Thermosynechococ
cus
elongatus) 		5 / 10 ALA A 329
LEU A 326
VAL A 325
VAL A   4
ILE A  31
 None
 1.05A 5v02B-3zdfA:
undetectable
5v02R-3zdfA:
undetectable		 5v02B-3zdfA:
15.13
5v02R-3zdfA:
16.19