SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zdu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		4 / 5 HIS A 244
LEU A 201
SER A 221
LEU A 224
 None
 1.07A 1a4lB-3zduA:
undetectable		 1a4lB-3zduA:
21.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		7 / 12 GLY A  11
VAL A  18
ALA A  31
VAL A  63
ASN A 130
LEU A 132
ASP A 143
 38R  A 350 ( 3.9A)
38R  A 350 ( 4.8A)
38R  A 350 (-3.4A)
38R  A 350 ( 4.9A)
38R  A 350 (-4.2A)
38R  A 350 (-4.3A)
NA  A 353 ( 2.5A)
 0.75A 1fmoE-3zduA:
25.5		 1fmoE-3zduA:
30.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		6 / 12 VAL A  18
ALA A  31
GLU A  50
VAL A  63
PHE A  81
LEU A 132
 38R  A 350 ( 4.8A)
38R  A 350 (-3.4A)
38R  A 350 ( 4.8A)
38R  A 350 ( 4.9A)
38R  A 350 (-4.2A)
38R  A 350 (-4.3A)
 0.49A 1opjA-3zduA:
22.3		 1opjA-3zduA:
28.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		6 / 12 ALA A  31
LYS A  33
GLU A  50
LEU A  54
LEU A 116
HIS A 123
 38R  A 350 (-3.4A)
38R  A 350 (-2.9A)
38R  A 350 ( 4.8A)
None
None
None
 0.81A 1uwhB-3zduA:
22.9		 1uwhB-3zduA:
26.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		7 / 12 VAL A  18
LYS A  33
VAL A  63
PHE A  79
ASN A 130
LEU A 132
ASP A 143
 38R  A 350 ( 4.8A)
38R  A 350 (-2.9A)
38R  A 350 ( 4.9A)
38R  A 350 (-4.1A)
38R  A 350 (-4.2A)
38R  A 350 (-4.3A)
NA  A 353 ( 2.5A)
 0.60A 2eufB-3zduA:
29.7		 2eufB-3zduA:
35.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		6 / 12 VAL A  18
ALA A  31
GLU A  50
VAL A  63
PHE A  81
LEU A 132
 38R  A 350 ( 4.8A)
38R  A 350 (-3.4A)
38R  A 350 ( 4.8A)
38R  A 350 ( 4.9A)
38R  A 350 (-4.2A)
38R  A 350 (-4.3A)
 0.54A 2hyyC-3zduA:
22.6		 2hyyC-3zduA:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		7 / 12 GLY A  11
VAL A  18
LYS A  33
GLU A  50
LEU A  54
LEU A  77
LEU A 132
 38R  A 350 ( 3.9A)
38R  A 350 ( 4.8A)
38R  A 350 (-2.9A)
38R  A 350 ( 4.8A)
None
None
38R  A 350 (-4.3A)
 0.62A 2ivuA-3zduA:
25.0		 2ivuA-3zduA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		7 / 12 GLY A  11
ALA A  31
LYS A  33
VAL A  63
PHE A  81
LEU A 132
CYH A 142
 38R  A 350 ( 3.9A)
38R  A 350 (-3.4A)
38R  A 350 (-2.9A)
38R  A 350 ( 4.9A)
38R  A 350 (-4.2A)
38R  A 350 (-4.3A)
38R  A 350 ( 3.9A)
 0.69A 3c7qA-3zduA:
21.5		 3c7qA-3zduA:
27.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		5 / 12 ALA A  31
GLU A  50
LEU A  62
PHE A  81
HIS A 123
 38R  A 350 (-3.4A)
38R  A 350 ( 4.8A)
None
38R  A 350 (-4.2A)
None
 0.72A 3cs9C-3zduA:
22.4		 3cs9C-3zduA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		5 / 12 LEU A  54
GLU A  50
ASP A 143
LEU A 116
PHE A  79
 None
38R  A 350 ( 4.8A)
NA  A 353 ( 2.5A)
None
38R  A 350 (-4.1A)
 1.37A 3g1uC-3zduA:
undetectable		 3g1uC-3zduA:
21.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		5 / 12 VAL A  10
ALA A  31
LYS A  33
GLU A  50
LEU A  54
 38R  A 350 (-4.4A)
38R  A 350 (-3.4A)
38R  A 350 (-2.9A)
38R  A 350 ( 4.8A)
None
 0.72A 3hecA-3zduA:
21.9		 3hecA-3zduA:
33.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		6 / 12 VAL A  10
VAL A  18
ALA A  31
LYS A  33
GLU A  50
LEU A  54
 38R  A 350 (-4.4A)
38R  A 350 ( 4.8A)
38R  A 350 (-3.4A)
38R  A 350 (-2.9A)
38R  A 350 ( 4.8A)
None
 0.87A 3hegA-3zduA:
25.3		 3hegA-3zduA:
33.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		5 / 12 ALA A  31
LEU A  62
VAL A  63
HIS A 123
LEU A 132
 38R  A 350 (-3.4A)
None
38R  A 350 ( 4.9A)
None
38R  A 350 (-4.3A)
 0.60A 3ik3A-3zduA:
16.5		 3ik3A-3zduA:
28.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		5 / 12 ALA A  31
LEU A  62
VAL A  63
HIS A 123
LEU A 132
 38R  A 350 (-3.4A)
None
38R  A 350 ( 4.9A)
None
38R  A 350 (-4.3A)
 0.64A 3ik3B-3zduA:
22.0		 3ik3B-3zduA:
28.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		5 / 8 VAL A  10
ALA A  31
LYS A  33
GLU A  50
LEU A  77
 38R  A 350 (-4.4A)
38R  A 350 (-3.4A)
38R  A 350 (-2.9A)
38R  A 350 ( 4.8A)
None
 0.52A 3lfaA-3zduA:
25.3		 3lfaA-3zduA:
33.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		6 / 11 ALA A  31
LYS A  33
VAL A  63
PHE A  79
PHE A  81
LEU A 132
 38R  A 350 (-3.4A)
38R  A 350 (-2.9A)
38R  A 350 ( 4.9A)
38R  A 350 (-4.1A)
38R  A 350 (-4.2A)
38R  A 350 (-4.3A)
 0.64A 3miyA-3zduA:
24.2		 3miyA-3zduA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		6 / 12 VAL A  10
GLY A  11
VAL A  18
ALA A  31
LYS A  33
LEU A  54
 38R  A 350 (-4.4A)
38R  A 350 ( 3.9A)
38R  A 350 ( 4.8A)
38R  A 350 (-3.4A)
38R  A 350 (-2.9A)
None
 0.81A 3ohtA-3zduA:
6.6		 3ohtA-3zduA:
29.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		5 / 12 ALA A 195
MET A 190
LEU A 110
ILE A 262
THR A 196
 None
 1.18A 3qfxA-3zduA:
undetectable		 3qfxA-3zduA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		5 / 12 ALA A 195
MET A 190
LEU A 110
ILE A 262
THR A 196
 None
 1.19A 3qfxB-3zduA:
undetectable		 3qfxB-3zduA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		7 / 12 VAL A  18
ALA A  31
GLU A  50
LEU A  54
PHE A  79
LEU A 116
HIS A 123
 38R  A 350 ( 4.8A)
38R  A 350 (-3.4A)
38R  A 350 ( 4.8A)
None
38R  A 350 (-4.1A)
None
None
 0.74A 3rgfA-3zduA:
12.1		 3rgfA-3zduA:
28.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		5 / 9 ALA A  31
VAL A  63
PHE A  79
PHE A  81
LEU A 132
 38R  A 350 (-3.4A)
38R  A 350 ( 4.9A)
38R  A 350 (-4.1A)
38R  A 350 (-4.2A)
38R  A 350 (-4.3A)
 0.55A 3ti1A-3zduA:
28.8		 3ti1A-3zduA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		5 / 9 VAL A  63
PHE A  79
PHE A  81
LEU A 132
ASP A 143
 38R  A 350 ( 4.9A)
38R  A 350 (-4.1A)
38R  A 350 (-4.2A)
38R  A 350 (-4.3A)
NA  A 353 ( 2.5A)
 0.96A 3ti1A-3zduA:
28.8		 3ti1A-3zduA:
34.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		6 / 12 GLY A  13
GLY A  16
VAL A  18
ALA A  31
LYS A  33
ASP A 143
 None
None
38R  A 350 ( 4.8A)
38R  A 350 (-3.4A)
38R  A 350 (-2.9A)
NA  A 353 ( 2.5A)
 0.77A 3v5wA-3zduA:
7.8		 3v5wA-3zduA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		4 / 8 VAL A  18
LYS A  33
PHE A  79
ASP A 143
 38R  A 350 ( 4.8A)
38R  A 350 (-2.9A)
38R  A 350 (-4.1A)
NA  A 353 ( 2.5A)
 0.52A 3warA-3zduA:
28.6		 3warA-3zduA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		8 / 12 VAL A  18
ALA A  31
LYS A  33
GLU A  50
LEU A  54
PHE A  81
LEU A 116
HIS A 123
 38R  A 350 ( 4.8A)
38R  A 350 (-3.4A)
38R  A 350 (-2.9A)
38R  A 350 ( 4.8A)
None
38R  A 350 (-4.2A)
None
None
 0.68A 3wzeA-3zduA:
22.2		 3wzeA-3zduA:
27.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		4 / 8 VAL A  63
LEU A 132
CYH A 142
ASP A 143
 38R  A 350 ( 4.9A)
38R  A 350 (-4.3A)
38R  A 350 ( 3.9A)
NA  A 353 ( 2.5A)
 0.62A 3wzeA-3zduA:
22.2		 3wzeA-3zduA:
27.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		8 / 12 VAL A  18
ALA A  31
LYS A  33
GLU A  50
VAL A  63
PHE A  81
LEU A 132
CYH A 142
 38R  A 350 ( 4.8A)
38R  A 350 (-3.4A)
38R  A 350 (-2.9A)
38R  A 350 ( 4.8A)
38R  A 350 ( 4.9A)
38R  A 350 (-4.2A)
38R  A 350 (-4.3A)
38R  A 350 ( 3.9A)
 0.65A 4ag8A-3zduA:
22.2		 4ag8A-3zduA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		8 / 12 VAL A  18
ALA A  31
LYS A  33
GLU A  50
LEU A  54
PHE A  81
LEU A 116
HIS A 123
 38R  A 350 ( 4.8A)
38R  A 350 (-3.4A)
38R  A 350 (-2.9A)
38R  A 350 ( 4.8A)
None
38R  A 350 (-4.2A)
None
None
 0.79A 4asdA-3zduA:
7.2		 4asdA-3zduA:
27.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		3 / 3 PRO A 240
ASN A 219
HIS A 244
 None
 0.88A 4ma3H-3zduA:
undetectable
4ma3L-3zduA:
undetectable		 4ma3H-3zduA:
20.66
4ma3L-3zduA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		4 / 6 VAL A  18
ALA A  31
THR A  85
LEU A 132
 38R  A 350 ( 4.8A)
38R  A 350 (-3.4A)
38R  A 350 (-4.2A)
38R  A 350 (-4.3A)
 0.66A 4o0uA-3zduA:
8.5		 4o0uA-3zduA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		5 / 12 GLY A 188
ILE A 262
LEU A 110
PHE A 107
ILE A 292
 None
 1.03A 4pd4C-3zduA:
undetectable		 4pd4C-3zduA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		5 / 12 LEU A  54
GLU A  50
ASP A 143
LEU A 116
PHE A  79
 None
38R  A 350 ( 4.8A)
NA  A 353 ( 2.5A)
None
38R  A 350 (-4.1A)
 1.35A 4pgfA-3zduA:
undetectable		 4pgfA-3zduA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		6 / 12 ALA A  31
LYS A  33
LEU A  54
HIS A 123
LEU A 132
CYH A 142
 38R  A 350 (-3.4A)
38R  A 350 (-2.9A)
None
None
38R  A 350 (-4.3A)
38R  A 350 ( 3.9A)
 0.49A 4u0iA-3zduA:
22.4		 4u0iA-3zduA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		5 / 12 ALA A  31
LYS A  33
LEU A  54
ASP A 143
PHE A 144
 38R  A 350 (-3.4A)
38R  A 350 (-2.9A)
None
NA  A 353 ( 2.5A)
None
 0.80A 4xv2B-3zduA:
23.1		 4xv2B-3zduA:
28.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		5 / 12 VAL A  18
ALA A  31
LYS A  33
LEU A  54
PHE A 144
 38R  A 350 ( 4.8A)
38R  A 350 (-3.4A)
38R  A 350 (-2.9A)
None
None
 0.82A 5cswA-3zduA:
22.8		 5cswA-3zduA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		6 / 12 ALA A  31
LYS A  33
GLU A  50
LEU A  54
LEU A 116
HIS A 123
 38R  A 350 (-3.4A)
38R  A 350 (-2.9A)
38R  A 350 ( 4.8A)
None
None
None
 0.90A 5hi2A-3zduA:
23.1		 5hi2A-3zduA:
28.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		4 / 7 GLY A  11
GLY A  13
GLY A  16
VAL A  18
 38R  A 350 ( 3.9A)
None
None
38R  A 350 ( 4.8A)
 0.33A 5izjB-3zduA:
24.4		 5izjB-3zduA:
31.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		4 / 7 GLY A  11
GLY A  13
VAL A  18
LYS A  33
 38R  A 350 ( 3.9A)
None
38R  A 350 ( 4.8A)
38R  A 350 (-2.9A)
 0.29A 5izjA-3zduA:
24.9		 5izjA-3zduA:
31.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		5 / 7 GLY A  11
GLY A  13
VAL A  18
LYS A  33
ASP A 143
 38R  A 350 ( 3.9A)
None
38R  A 350 ( 4.8A)
38R  A 350 (-2.9A)
NA  A 353 ( 2.5A)
 0.54A 5j5xA-3zduA:
25.3		 5j5xA-3zduA:
31.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		7 / 12 GLY A  11
TYR A  15
VAL A  18
ALA A  31
VAL A  63
PHE A  79
LEU A 132
 38R  A 350 ( 3.9A)
None
38R  A 350 ( 4.8A)
38R  A 350 (-3.4A)
38R  A 350 ( 4.9A)
38R  A 350 (-4.1A)
38R  A 350 (-4.3A)
 0.79A 5l2iA-3zduA:
12.4		 5l2iA-3zduA:
33.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		5 / 12 ALA A  31
LEU A  62
VAL A  63
HIS A 123
LEU A 132
 38R  A 350 (-3.4A)
None
38R  A 350 ( 4.9A)
None
38R  A 350 (-4.3A)
 0.63A 5mo4A-3zduA:
16.5		 5mo4A-3zduA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		5 / 12 TYR A 200
GLY A 188
GLN A 268
VAL A 263
LEU A 259
 None
 1.30A 5ubbA-3zduA:
undetectable		 5ubbA-3zduA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		5 / 10 TYR A 105
ILE A 109
ILE A 113
LEU A 116
HIS A  84
 None
 1.08A 5vkqA-3zduA:
undetectable
5vkqD-3zduA:
undetectable		 5vkqA-3zduA:
11.68
5vkqD-3zduA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		5 / 10 HIS A  84
TYR A 105
ILE A 109
ILE A 113
LEU A 116
 None
 1.09A 5vkqA-3zduA:
undetectable
5vkqB-3zduA:
undetectable		 5vkqA-3zduA:
11.68
5vkqB-3zduA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		4 / 9 TYR A 105
ILE A 109
ILE A 113
LEU A 116
 None
 0.74A 5vkqB-3zduA:
undetectable
5vkqC-3zduA:
undetectable		 5vkqB-3zduA:
11.68
5vkqC-3zduA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		5 / 10 HIS A  84
TYR A 105
ILE A 109
ILE A 113
LEU A 116
 None
 1.04A 5vkqC-3zduA:
undetectable
5vkqD-3zduA:
undetectable		 5vkqC-3zduA:
11.68
5vkqD-3zduA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		7 / 12 ALA A  31
LYS A  33
GLU A  50
LEU A  77
LEU A 132
CYH A 142
ASP A 143
 38R  A 350 (-3.4A)
38R  A 350 (-2.9A)
38R  A 350 ( 4.8A)
None
38R  A 350 (-4.3A)
38R  A 350 ( 3.9A)
NA  A 353 ( 2.5A)
 0.91A 5y7zB-3zduA:
23.8		 5y7zB-3zduA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		4 / 8 VAL A  18
LYS A  33
PHE A  79
ASP A 143
 38R  A 350 ( 4.8A)
38R  A 350 (-2.9A)
38R  A 350 (-4.1A)
NA  A 353 ( 2.5A)
 0.35A 5y9mX-3zduA:
26.8		 5y9mX-3zduA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		4 / 7 VAL A  18
LYS A  33
PHE A  79
ASP A 143
 38R  A 350 ( 4.8A)
38R  A 350 (-2.9A)
38R  A 350 (-4.1A)
NA  A 353 ( 2.5A)
 0.50A 5yf9B-3zduA:
26.7		 5yf9B-3zduA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		4 / 7 VAL A  18
LYS A  33
PHE A  79
ASP A 143
 38R  A 350 ( 4.8A)
38R  A 350 (-2.9A)
38R  A 350 (-4.1A)
NA  A 353 ( 2.5A)
 0.47A 5ywmX-3zduA:
26.8		 5ywmX-3zduA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		5 / 12 LEU A  54
GLU A  50
ASP A 143
LEU A 116
PHE A  79
 None
38R  A 350 ( 4.8A)
NA  A 353 ( 2.5A)
None
38R  A 350 (-4.1A)
 1.33A 6aphA-3zduA:
undetectable		 6aphA-3zduA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		5 / 12 PHE A 286
PHE A 295
ALA A 265
ILE A 131
LEU A 110
 None
 1.00A 6aybA-3zduA:
undetectable		 6aybA-3zduA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_1
(-)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		5 / 12 LEU A  54
GLU A  50
ASP A 143
LEU A 116
PHE A  79
 None
38R  A 350 ( 4.8A)
NA  A 353 ( 2.5A)
None
38R  A 350 (-4.1A)
 1.43A 6gbnB-3zduA:
undetectable		 6gbnB-3zduA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_1
(-)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		5 / 12 LEU A  54
GLU A  50
ASP A 143
LEU A 116
PHE A  79
 None
38R  A 350 ( 4.8A)
NA  A 353 ( 2.5A)
None
38R  A 350 (-4.1A)
 1.44A 6gbnC-3zduA:
undetectable		 6gbnC-3zduA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		4 / 8 ILE A 156
ARG A 124
ASN A  44
TYR A  15
 None
 1.25A 6hisA-3zduA:
undetectable
6hisB-3zduA:
undetectable		 6hisA-3zduA:
11.82
6hisB-3zduA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		4 / 8 ILE A 156
ARG A 124
ASN A  44
TYR A  15
 None
 1.25A 6hisB-3zduA:
undetectable
6hisC-3zduA:
undetectable		 6hisB-3zduA:
11.82
6hisC-3zduA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		4 / 8 ILE A 156
ARG A 124
ASN A  44
TYR A  15
 None
 1.25A 6hisC-3zduA:
undetectable
6hisD-3zduA:
undetectable		 6hisC-3zduA:
11.82
6hisD-3zduA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		4 / 8 ILE A 156
ARG A 124
ASN A  44
TYR A  15
 None
 1.24A 6hisD-3zduA:
undetectable
6hisE-3zduA:
undetectable		 6hisD-3zduA:
11.82
6hisE-3zduA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		4 / 8 ASN A  44
TYR A  15
ILE A 156
ARG A 124
 None
 1.26A 6hisA-3zduA:
undetectable
6hisE-3zduA:
undetectable		 6hisA-3zduA:
11.82
6hisE-3zduA:
11.82