SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ze7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		4 / 8 PHE B  55
HIS B 427
ILE B  74
HIS B  82
 None
None
OCS  B  75 ( 3.9A)
FCO  B 500 (-4.3A)
 1.00A 1ei6D-3ze7B:
undetectable		 1ei6D-3ze7B:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		4 / 8 PHE B 289
TYR B  52
VAL B 494
GLY B  54
 None
 0.85A 1ekjE-3ze7B:
undetectable
1ekjF-3ze7B:
undetectable		 1ekjE-3ze7B:
20.42
1ekjF-3ze7B:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		4 / 6 CYH B  78
VAL B  77
HIS B  82
CYH B 492
 FCO  B 500 (-2.2A)
OCS  B  75 ( 3.3A)
FCO  B 500 (-4.3A)
FCO  B 500 ( 2.3A)
 1.41A 1ekjG-3ze7B:
undetectable
1ekjH-3ze7B:
undetectable		 1ekjG-3ze7B:
20.42
1ekjH-3ze7B:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		5 / 12 CYH B 489
HIS B 495
HIS B  82
LEU B 425
LEU B 446
 NI  B 501 ( 2.2A)
FE2  B 502 (-3.5A)
FCO  B 500 (-4.3A)
FCO  B 500 (-3.5A)
None
 1.34A 1fm6X-3ze7B:
undetectable		 1fm6X-3ze7B:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		5 / 12 LEU B 154
ASN B 155
GLY B 158
GLN B 161
VAL B 225
 None
 1.04A 1gs4A-3ze7B:
undetectable		 1gs4A-3ze7B:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		5 / 9 GLY B 102
GLY B 180
PHE B 179
ARG B 106
GLY B 188
 None
 1.31A 1jhoA-3ze7B:
undetectable		 1jhoA-3ze7B:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M9J_A_CLWA906_1
(ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		4 / 5 PRO B 339
VAL B 336
MET B 385
GLU B 381
 None
 1.01A 1m9jA-3ze7B:
undetectable		 1m9jA-3ze7B:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M9J_B_CLWB907_1
(ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		4 / 5 PRO B 339
VAL B 336
MET B 385
GLU B 381
 None
 1.02A 1m9jB-3ze7B:
undetectable		 1m9jB-3ze7B:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		5 / 11 VAL B  35
VAL B  37
GLU B 462
LEU B 482
ILE B 468
 None
 1.30A 1t6zB-3ze7B:
undetectable		 1t6zB-3ze7B:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		5 / 11 VAL B 213
VAL B 217
GLU B 164
TYR B 221
ILE B 119
 None
 1.42A 1t6zB-3ze7B:
undetectable		 1t6zB-3ze7B:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		5 / 12 PHE B 210
ILE B 109
ALA B 388
THR B 105
GLU B 196
 None
 1.35A 1vq1A-3ze7B:
undetectable		 1vq1A-3ze7B:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		5 / 12 LEU B 154
ASN B 155
GLY B 158
GLN B 161
VAL B 225
 None
 1.14A 2oz7A-3ze7B:
undetectable		 2oz7A-3ze7B:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		5 / 12 LEU B 154
ASN B 155
GLY B 158
GLN B 161
VAL B 225
 None
 1.11A 2q7lA-3ze7B:
undetectable		 2q7lA-3ze7B:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		4 / 6 ARG B 422
TYR B 114
THR B  80
ALA B  81
 FCO  B 500 (-4.2A)
None
H2S  B 503 (-4.1A)
H2S  B 503 (-3.5A)
 1.27A 2ql8A-3ze7B:
undetectable
2ql8B-3ze7B:
undetectable		 2ql8A-3ze7B:
18.18
2ql8B-3ze7B:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		3 / 3 SER B 117
ARG B 169
GLN B 116
 None
 0.76A 2xnrA-3ze7B:
undetectable		 2xnrA-3ze7B:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		4 / 6 ARG B  26
PHE B 130
ASP B 147
TYR B 232
 None
 1.30A 3jqaA-3ze7B:
undetectable		 3jqaA-3ze7B:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		4 / 6 ARG B  26
PHE B 130
ASP B 147
TYR B 232
 None
 1.28A 3jqaB-3ze7B:
undetectable		 3jqaB-3ze7B:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		4 / 6 ARG B  26
PHE B 130
ASP B 147
TYR B 232
 None
 1.31A 3jqaC-3ze7B:
undetectable		 3jqaC-3ze7B:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		4 / 6 ARG B  26
PHE B 130
ASP B 147
TYR B 232
 None
 1.32A 3jqaD-3ze7B:
undetectable		 3jqaD-3ze7B:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_D_VIAD901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		5 / 11 GLN B 116
ALA B  85
MET B 183
GLN B 189
PHE B 110
 None
None
None
None
H2S  B 503 (-4.8A)
 1.42A 3jwqA-3ze7B:
undetectable
3jwqD-3ze7B:
undetectable		 3jwqA-3ze7B:
21.44
3jwqD-3ze7B:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		4 / 5 GLY B 192
ASP B  91
GLN B  72
MET B 183
 None
 1.49A 3qx3B-3ze7B:
undetectable		 3qx3B-3ze7B:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		5 / 12 PHE B 417
GLY B 416
ARG B 422
GLY B 249
ALA B 420
 None
None
FCO  B 500 (-4.2A)
None
FCO  B 500 (-3.2A)
 1.08A 3sueD-3ze7B:
undetectable		 3sueD-3ze7B:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		4 / 7 GLY B 459
PRO B 451
TYR B 313
GLY B  49
 None
 0.76A 3tajA-3ze7B:
undetectable		 3tajA-3ze7B:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		4 / 6 LEU B 371
HIS B 375
MET B 372
ARG B 149
 None
 1.35A 3thrB-3ze7B:
undetectable		 3thrB-3ze7B:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		4 / 8 PHE B 262
THR B 418
GLY B 111
PHE B 110
 None
None
None
H2S  B 503 (-4.8A)
 0.72A 3tzfB-3ze7B:
undetectable		 3tzfB-3ze7B:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		5 / 12 VAL B  37
ILE B  27
ILE B 483
LEU B 465
VAL B  42
 None
 0.89A 3w68C-3ze7B:
undetectable		 3w68C-3ze7B:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		5 / 12 VAL B  37
ILE B  27
ILE B 483
LEU B 465
VAL B  42
 None
 0.91A 3w68D-3ze7B:
undetectable		 3w68D-3ze7B:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		5 / 8 THR B 382
LEU B 115
ARG B 214
VAL B 213
VAL B 217
 None
 1.36A 4em2A-3ze7B:
undetectable		 4em2A-3ze7B:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		4 / 6 GLY B 459
PRO B 451
TYR B 313
GLY B  49
 None
 0.69A 4fjpA-3ze7B:
undetectable		 4fjpA-3ze7B:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		4 / 7 GLY B 459
PRO B 451
TYR B 313
GLY B  49
 None
 0.68A 4forA-3ze7B:
undetectable		 4forA-3ze7B:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		3 / 3 PRO B 451
TYR B 313
GLY B  49
 None
 0.72A 4g2zA-3ze7B:
undetectable		 4g2zA-3ze7B:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		5 / 12 ILE B 104
ASP B  91
ALA B  96
VAL B 404
GLY B 193
 None
 1.14A 4hfpD-3ze7B:
undetectable		 4hfpD-3ze7B:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLW_A_TESA1001_1
(ANDROGEN RECEPTOR)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		5 / 12 LEU B 154
ASN B 155
GLY B 158
GLN B 161
VAL B 225
 None
 1.12A 4hlwA-3ze7B:
undetectable		 4hlwA-3ze7B:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		3 / 3 ARG B 103
GLU B 395
ASN B 100
 None
 0.87A 4imaD-3ze7B:
undetectable		 4imaD-3ze7B:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		3 / 3 ARG B 103
GLU B 395
ASN B 100
 None
 0.90A 4ip7D-3ze7B:
undetectable		 4ip7D-3ze7B:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		3 / 3 PRO B  79
ASN B 113
HIS B 173
 OCS  B  75 ( 3.1A)
H2S  B 503 (-4.1A)
None
 1.00A 4ma3H-3ze7B:
undetectable
4ma3L-3ze7B:
undetectable		 4ma3H-3ze7B:
18.59
4ma3L-3ze7B:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		5 / 12 PRO B  64
ALA B  93
ALA B  85
GLY B 416
LEU B 426
 None
 0.98A 4oaeA-3ze7B:
undetectable		 4oaeA-3ze7B:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		4 / 5 LEU B 465
ALA B 485
VAL B  24
ILE B  27
 None
 0.95A 4xe3A-3ze7B:
undetectable		 4xe3A-3ze7B:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		4 / 5 LEU B 465
ALA B 485
VAL B  24
ILE B  27
 None
 0.94A 4xe3B-3ze7B:
undetectable		 4xe3B-3ze7B:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		4 / 6 ASP B  91
GLU B  92
ILE B 441
HIS B  82
 None
None
FE2  B 502 (-4.6A)
FCO  B 500 (-4.3A)
 1.03A 4xi3C-3ze7B:
undetectable		 4xi3C-3ze7B:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		4 / 6 LEU B 446
ASN B 450
PRO B 319
ARG B 333
 None
 1.44A 4yv5A-3ze7B:
0.4		 4yv5A-3ze7B:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWY_E_010E6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		4 / 4 THR B 418
LEU B 425
HIS B  82
GLY B 423
 None
FCO  B 500 (-3.5A)
FCO  B 500 (-4.3A)
None
 1.30A 5gwyA-3ze7B:
undetectable		 5gwyA-3ze7B:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_J_EDTJ301_0
(TCRBETA CHAIN)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		4 / 5 TYR B 298
LYS B 299
GLU B 413
GLY B 414
 None
 1.38A 5jhdJ-3ze7B:
undetectable		 5jhdJ-3ze7B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		3 / 3 ARG B 422
PRO B 421
ASN B 113
 FCO  B 500 (-4.2A)
FCO  B 500 ( 3.6A)
H2S  B 503 (-4.1A)
 0.93A 5jwaA-3ze7B:
undetectable
5jwaH-3ze7B:
undetectable		 5jwaA-3ze7B:
22.80
5jwaH-3ze7B:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		6 / 9 ILE B 466
GLY B 467
VAL B  42
ALA B  45
ILE B 483
LEU B 482
 None
 1.12A 5lw1B-3ze7B:
undetectable		 5lw1B-3ze7B:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_E_SAME501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		5 / 9 LEU B 490
GLY B  50
SER B 445
LEU B  47
ARG B  46
 None
None
FCO  B 500 (-2.8A)
None
None
 1.29A 5o96E-3ze7B:
undetectable
5o96F-3ze7B:
undetectable		 5o96E-3ze7B:
19.42
5o96F-3ze7B:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2O_A_8N6A501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		5 / 12 CYH B 489
HIS B 495
HIS B  82
LEU B 425
LEU B 446
 NI  B 501 ( 2.2A)
FE2  B 502 (-3.5A)
FCO  B 500 (-4.3A)
FCO  B 500 (-3.5A)
None
 1.35A 5y2oA-3ze7B:
undetectable		 5y2oA-3ze7B:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		3 / 3 MET B 235
ASP B 147
ARG B  26
 None
 1.19A 5z6kA-3ze7B:
undetectable		 5z6kA-3ze7B:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		4 / 6 GLU B 462
ARG B  46
ARG B 458
ASP B 453
 None
 1.06A 5zw4A-3ze7B:
undetectable		 5zw4A-3ze7B:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		4 / 6 SER B 325
GLU B 462
ARG B  46
ASP B 453
 None
 1.26A 5zw4A-3ze7B:
undetectable		 5zw4A-3ze7B:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		5 / 12 PHE B 417
GLY B 416
ARG B 422
GLY B 249
ALA B 420
 None
None
FCO  B 500 (-4.2A)
None
FCO  B 500 (-3.2A)
 1.11A 6c2mA-3ze7B:
undetectable		 6c2mA-3ze7B:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		5 / 12 ASP B 234
ALA B 367
GLY B 229
ARG B 149
VAL B 376
 None
 1.06A 6clxA-3ze7B:
undetectable		 6clxA-3ze7B:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING
(Desulfovibrio
vulgaris) 		4 / 8 VAL B 248
HIS B 427
TYR B 298
GLU B  92
 None
 1.11A 6gneB-3ze7B:
undetectable		 6gneB-3ze7B:
21.58