SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zef'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		5 / 12 ILE B1400
ALA B1402
PHE B1312
ILE B1319
TYR B1389
 None
 1.11A 1dhfB-3zefB:
undetectable		 1dhfB-3zefB:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		5 / 12 ILE B1400
ALA B1402
PHE B1312
ILE B1319
TYR B1389
 None
 1.07A 1dlsA-3zefB:
undetectable		 1dlsA-3zefB:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		5 / 11 LEU B1171
ALA B1047
LEU B1049
SER B1249
VAL B1041
 None
 1.13A 1ictA-3zefB:
undetectable
1ictC-3zefB:
undetectable		 1ictA-3zefB:
7.22
1ictC-3zefB:
7.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		4 / 6 LEU B1171
ALA B1047
LEU B1049
SER B1249
 None
 0.94A 1ictB-3zefB:
undetectable		 1ictB-3zefB:
7.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		4 / 7 ILE B1061
GLY B1102
ASN B1087
ASN B1099
 None
 0.84A 1oniG-3zefB:
undetectable
1oniI-3zefB:
undetectable		 1oniG-3zefB:
6.79
1oniI-3zefB:
6.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		3 / 3 LYS B1690
ASP B1670
ASP B1700
 None
 0.90A 2br4D-3zefB:
undetectable		 2br4D-3zefB:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG3_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		5 / 11 ASP B 996
PHE B1112
VAL B1074
ILE B1078
ILE B 911
 None
 1.33A 2dg3A-3zefB:
undetectable		 2dg3A-3zefB:
6.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		4 / 5 VAL B1304
SER B1261
VAL B1267
SER B1305
 None
 1.12A 2j9cA-3zefB:
1.3
2j9cB-3zefB:
1.1
2j9cC-3zefB:
undetectable		 2j9cA-3zefB:
6.30
2j9cB-3zefB:
6.30
2j9cC-3zefB:
6.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		4 / 7 GLY B2231
THR B2360
GLN B2229
PHE B2193
 None
 0.96A 2qx4A-3zefB:
undetectable
2qx4B-3zefB:
undetectable		 2qx4A-3zefB:
9.31
2qx4B-3zefB:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		5 / 11 HIS B1658
LEU B1738
VAL B1736
MET B1806
ILE B1665
 None
 0.89A 2uxoB-3zefB:
undetectable		 2uxoB-3zefB:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		5 / 10 ASP B1674
ILE B1665
PHE B1791
ILE B1775
GLY B1793
 None
 1.35A 2v0mA-3zefB:
0.0		 2v0mA-3zefB:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		4 / 7 PHE B1724
SER B1801
LEU B1676
ILE B1668
 None
 0.85A 2v0mC-3zefB:
undetectable		 2v0mC-3zefB:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_D_BEZD1221_0
(PEROXIREDOXIN 6)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		4 / 8 VAL B2227
PRO B2228
PRO B2352
SER B2353
 None
 0.93A 2v32C-3zefB:
2.2
2v32D-3zefB:
2.0		 2v32C-3zefB:
9.16
2v32D-3zefB:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		4 / 8 ILE B1113
LEU B1066
ARG B1105
GLY B1102
 None
 0.97A 2vdbA-3zefB:
undetectable		 2vdbA-3zefB:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		5 / 12 ILE B1400
ALA B1402
PHE B1312
ILE B1319
TYR B1389
 None
 1.15A 2w3bB-3zefB:
undetectable		 2w3bB-3zefB:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		5 / 12 ILE B1400
ALA B1402
PHE B1312
ILE B1319
TYR B1389
 None
 1.14A 2w3mA-3zefB:
undetectable		 2w3mA-3zefB:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		4 / 5 ILE B1090
PRO B 966
VAL B1074
PHE B 964
 None
 1.12A 2ygnA-3zefB:
undetectable		 2ygnA-3zefB:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		4 / 5 LEU B1302
ILE B1020
TRP B1526
TYR B1026
 None
 1.43A 2zlcA-3zefB:
undetectable		 2zlcA-3zefB:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		4 / 8 ILE B1632
LEU B1645
PHE B1649
LEU B1561
 None
 0.92A 3ag3N-3zefB:
2.7
3ag3W-3zefB:
undetectable		 3ag3N-3zefB:
16.71
3ag3W-3zefB:
4.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DGQ_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		4 / 5 TYR B1164
ARG B1509
TYR B1345
THR B1344
 None
 1.12A 3dgqA-3zefB:
undetectable		 3dgqA-3zefB:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		4 / 6 ILE B2079
THR B1936
PHE B1965
PHE B2005
 None
 1.27A 3elzB-3zefB:
undetectable		 3elzB-3zefB:
6.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		4 / 5 ILE B1556
THR B1613
PHE B1383
PHE B1388
 None
 1.10A 3em0A-3zefB:
1.3		 3em0A-3zefB:
6.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		4 / 7 TYR B1164
TYR B1345
THR B1344
GLY B1264
 None
 0.99A 3gssB-3zefB:
0.3		 3gssB-3zefB:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		3 / 3 GLU B1513
PHE B1514
GLN B1115
 None
 0.97A 3r55A-3zefB:
undetectable		 3r55A-3zefB:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_A_9PLA501_1
(CYTOCHROME P450 2A6)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		5 / 10 PHE B2005
PHE B1844
THR B1959
ILE B1934
PHE B1851
 None
 1.12A 3t3qA-3zefB:
undetectable		 3t3qA-3zefB:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_B_9PLB501_1
(CYTOCHROME P450 2A6)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		5 / 10 PHE B2005
PHE B1844
THR B1959
ILE B1934
PHE B1851
 None
 1.15A 3t3qB-3zefB:
undetectable		 3t3qB-3zefB:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_C_9PLC501_1
(CYTOCHROME P450 2A6)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		5 / 10 PHE B2005
PHE B1844
THR B1959
ILE B1934
PHE B1851
 None
 1.14A 3t3qC-3zefB:
undetectable		 3t3qC-3zefB:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_D_9PLD501_1
(CYTOCHROME P450 2A6)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		5 / 10 PHE B2005
PHE B1844
THR B1959
ILE B1934
PHE B1851
 None
 1.15A 3t3qD-3zefB:
undetectable		 3t3qD-3zefB:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_C_9PLC1_1
(CYTOCHROME P450 2A13)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		4 / 7 PHE B2329
ASN B2318
ALA B2275
LEU B2307
 None
 1.05A 3t3sC-3zefB:
undetectable		 3t3sC-3zefB:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		4 / 5 ASP B1485
SER B1483
GLY B1482
TRP B1484
 None
 1.26A 3w9tB-3zefB:
undetectable		 3w9tB-3zefB:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1003_1
(HEMOLYTIC LECTIN
CEL-III)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		4 / 5 ASP B1485
SER B1483
GLY B1482
TRP B1484
 None
 1.26A 3w9tC-3zefB:
undetectable		 3w9tC-3zefB:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD501_1
(HEMOLYTIC LECTIN
CEL-III)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		4 / 5 ASP B1485
SER B1483
GLY B1482
TRP B1484
 None
 1.26A 3w9tD-3zefB:
undetectable		 3w9tD-3zefB:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF501_1
(HEMOLYTIC LECTIN
CEL-III)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		4 / 4 ASP B1485
SER B1483
GLY B1482
TRP B1484
 None
 1.26A 3w9tF-3zefB:
0.0		 3w9tF-3zefB:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		4 / 8 SER B2326
ASN B2318
ILE B2321
ASN B1472
 None
 0.79A 4d33A-3zefB:
undetectable		 4d33A-3zefB:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		4 / 7 SER B2326
ASN B2318
ILE B2321
ASN B1472
 None
 0.80A 4d33B-3zefB:
undetectable		 4d33B-3zefB:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		4 / 8 SER B2326
ASN B2318
ILE B2321
ASN B1472
 None
 0.78A 4d39A-3zefB:
undetectable		 4d39A-3zefB:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		4 / 7 LEU B1171
ALA B1047
LEU B1049
SER B1249
 None
 0.88A 4d7bA-3zefB:
undetectable		 4d7bA-3zefB:
5.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		3 / 3 TYR B1743
HIS B1559
ARG B1616
 None
 1.05A 4e7bC-3zefB:
undetectable		 4e7bC-3zefB:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		4 / 6 TRP B1335
ILE B1440
VAL B1361
ASP B1313
 None
 1.17A 4iaqA-3zefB:
undetectable		 4iaqA-3zefB:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		5 / 12 ILE B1400
ALA B1402
PHE B1312
ILE B1319
TYR B1389
 None
 1.14A 4kebB-3zefB:
undetectable		 4kebB-3zefB:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		3 / 3 ASP B 921
TRP B1537
SER B 925
 None
 0.80A 4lrhA-3zefB:
undetectable		 4lrhA-3zefB:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		3 / 3 ASP B1700
TRP B1790
SER B1697
 None
 0.92A 4lrhA-3zefB:
undetectable		 4lrhA-3zefB:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		3 / 3 LYS B2187
ASN B2348
ASP B2343
 None
 0.76A 4o1eA-3zefB:
undetectable		 4o1eA-3zefB:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		3 / 3 PRO B1925
LEU B1924
HIS B1888
 None
 0.57A 4pevA-3zefB:
2.8		 4pevA-3zefB:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		5 / 12 ILE B1013
GLN B1115
ILE B1073
ALA B1003
PHE B1112
 None
 1.05A 4rp8C-3zefB:
undetectable		 4rp8C-3zefB:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		3 / 3 ASN B1529
PHE B1525
TYR B1345
 None
 0.76A 4u15A-3zefB:
0.6		 4u15A-3zefB:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		4 / 5 ILE B1437
ILE B1400
TYR B1389
GLU B1364
 None
 1.27A 4zzcE-3zefB:
undetectable		 4zzcE-3zefB:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_1
(HIV-1 PROTEASE)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		6 / 12 ALA B1386
ASP B1411
ILE B1407
GLY B1552
ILE B1547
PRO B1438
 None
 1.36A 5e5kA-3zefB:
undetectable		 5e5kA-3zefB:
5.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		4 / 6 LYS B1755
TYR B1751
GLY B1631
ASP B1628
 None
 1.33A 5emlA-3zefB:
2.6		 5emlA-3zefB:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		5 / 9 ILE B2025
THR B2017
LEU B2058
GLN B2047
LEU B2010
 None
 1.38A 5fhzB-3zefB:
undetectable		 5fhzB-3zefB:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		4 / 7 LEU B1302
VAL B1304
GLU B1308
ILE B1444
 None
 1.13A 5jh7C-3zefB:
undetectable		 5jh7C-3zefB:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		4 / 6 LEU B1171
ALA B1047
LEU B1049
SER B1249
 None
 0.97A 5l4iA-3zefB:
undetectable		 5l4iA-3zefB:
7.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		3 / 3 MET B2055
GLN B2054
ARG B2056
 None
 1.11A 5m35B-3zefB:
3.6		 5m35B-3zefB:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		4 / 4 GLU B1019
PRO B1021
ILE B1020
LEU B1023
 None
 1.09A 5m45A-3zefB:
undetectable		 5m45A-3zefB:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		4 / 4 GLU B1019
PRO B1021
ILE B1020
LEU B1023
 None
 1.10A 5m45D-3zefB:
undetectable		 5m45D-3zefB:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		4 / 4 GLU B1019
PRO B1021
ILE B1020
LEU B1023
 None
 1.08A 5m45G-3zefB:
undetectable		 5m45G-3zefB:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		4 / 4 GLU B1019
PRO B1021
ILE B1020
LEU B1023
 None
 1.06A 5m45J-3zefB:
undetectable		 5m45J-3zefB:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		4 / 8 LEU B1963
PHE B2005
LEU B1882
ILE B1991
 None
 0.78A 5mzjA-3zefB:
3.4		 5mzjA-3zefB:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		5 / 10 PHE B1174
LEU B1182
GLY B1179
ILE B1241
LEU B1054
 None
 1.12A 5oy01-3zefB:
undetectable
5oy07-3zefB:
undetectable		 5oy01-3zefB:
4.56
5oy07-3zefB:
2.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		4 / 6 THR B 950
ARG B 953
ILE B 940
GLU B 941
 None
 1.20A 5uigA-3zefB:
undetectable		 5uigA-3zefB:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		5 / 10 LEU B1066
ILE B1078
LEU B 999
ALA B1110
LEU B1107
 None
 1.20A 5y7pG-3zefB:
undetectable		 5y7pG-3zefB:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		5 / 12 PHE B1312
PHE B1441
ILE B1440
TRP B1335
PHE B1343
 None
 1.13A 6ap6A-3zefB:
undetectable		 6ap6A-3zefB:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		5 / 12 PHE B1312
PHE B1441
ILE B1440
TRP B1335
PHE B1343
 None
 1.13A 6ap6B-3zefB:
undetectable		 6ap6B-3zefB:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		5 / 12 LEU B1850
LEU B1924
PRO B1925
PHE B1890
THR B1886
 None
 1.25A 6debB-3zefB:
undetectable		 6debB-3zefB:
4.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		3 / 3 LEU B 890
SER B 894
PHE B 895
 None
 0.57A 6fgcA-3zefB:
undetectable		 6fgcA-3zefB:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		3 / 3 MET B2055
GLN B2054
ARG B2056
 None
 1.12A 6fn9A-3zefB:
3.3		 6fn9A-3zefB:
10.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		3 / 3 MET B2055
GLN B2054
ARG B2056
 None
 1.10A 6fnaB-3zefB:
3.3		 6fnaB-3zefB:
10.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		3 / 3 MET B2055
GLN B2054
ARG B2056
 None
 1.13A 6fnbA-3zefB:
3.3		 6fnbA-3zefB:
10.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3zef PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		4 / 6 GLN B1146
PHE B1144
LEU B1023
PHE B1451
 None
 1.29A 6nmpC-3zefB:
undetectable
6nmpJ-3zefB:
undetectable		 6nmpC-3zefB:
10.07
6nmpJ-3zefB:
4.77